From 41c56f9a05ff88cb3c9055d00de204e7aa7d66c5 Mon Sep 17 00:00:00 2001 From: Andrea Alvarez Perez Date: Tue, 13 May 2025 12:48:28 +0000 Subject: [PATCH] Add new file --- figures/README.md | 14 ++++++++++++++ 1 file changed, 14 insertions(+) create mode 100644 figures/README.md diff --git a/figures/README.md b/figures/README.md new file mode 100644 index 0000000..56c6ec0 --- /dev/null +++ b/figures/README.md @@ -0,0 +1,14 @@ +# FIGURES + +## Structure + +| File | Description | +|-----------------------|-------------------------------------------------------------------------------------------------| +| [combined_heatmaps.svg](https://medal.ctb.upm.es/internal/gitlab/disnet/network-medicine/network-medicine-and-single-cell-for-alzheimer/figures/combined_heatmaps.svg) | (Left) Heatmap displaying the top 20 most differentially up- and down-regulated genes and the proteins they encode. The color intensity represents the \textit{logFC} values across cell types for Alzheimer's disease relative to a healthy baseline condition. (Right) Heatmap showing the differentially expressed proteins present in all eight cell types. | +| [volcano_per_type_notext.svg](https://medal.ctb.upm.es/internal/gitlab/disnet/network-medicine/network-medicine-and-single-cell-for-alzheimer/figures/volcano_per_type_notext.svg) | Volcano plots per cell type showing DEGs logFC vs. -log10(adjusted p-value), with the top 5 genes (by absolute logFC) highlighted; upregulated genes are in red, downregulated in blue.| +| [degree_boxplot.svg](https://medal.ctb.upm.es/internal/gitlab/disnet/network-medicine/network-medicine-and-single-cell-for-alzheimer/figures/degree_boxplot.svg) | Boxplots with the degree distribution of DEGs within the general AD module, and stratified by cell type subnetworks. | +| [betweenness_boxplot.svg](https://medal.ctb.upm.es/internal/gitlab/disnet/network-medicine/network-medicine-and-single-cell-for-alzheimer/figures/betweenness_boxplot.svg) | Boxplots with the betweenness centrality distribution of DEGs within the general AD module, and stratified by cell type subnetworks. | +| [closeness_boxplot.svg](https://medal.ctb.upm.es/internal/gitlab/disnet/network-medicine/network-medicine-and-single-cell-for-alzheimer/figures/closeness_boxplot.svg) | Boxplots with the closeness centrality distribution of DEGs within the general AD module, and stratified by cell type subnetworks. | +| [clustering_boxplot.svg](https://medal.ctb.upm.es/internal/gitlab/disnet/network-medicine/network-medicine-and-single-cell-for-alzheimer/figures/clustering_boxplot.svg) | Boxplots with the clustering coefficient distribution of DEGs within the general AD module, and stratified by cell type subnetworks. | +| [significance/random_modules_{cell type}.svg](https://medal.ctb.upm.es/internal/gitlab/disnet/network-medicine/network-medicine-and-single-cell-for-alzheimer/figures/significance/) | histograms showing the distribution of Largest Connected Component (LCC) sizes from 1,000 random protein subnetworks for each cell type. The observed LCC size from Alzheimer's-related proteins is highlighted in red, and the mean of the random distribution in blue. | + -- 2.24.1