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# SEM-DISNET

## Release 2022-06-10

Contributors:
  Andrea Álvarez Pérez (MEDAL)
  Ana Iglesias Molina (OEG)
  Lucía Prieto Santamaría (MEDAL)
  Alejandro Rodríguez González (MEDAL)
Publisher:
  Medical Data Analytics Laboratory (MEDAL): https://medal.ctb.upm.es/
  Ontology Engineering Group (OEG): https://oeg.fi.upm.es/
Download serialization:
License:

Provenance of this page

Ontology Specification Draft

## Introduction back to ToC

SEM-DISNET ontology provides a integrated ontology used to describe the defined entities which appear in the DISNET database. It is an ontology aimed at facilitating the analysis of biomedical data, allowing the discovery of new patterns and associations between genes, drugs and their targets to be applied in cases of drug repositioning. This project has been carried out within the DISNET project of MEDAL Laboratory (Medical Data Analytics) at the CTB-UPM, together with DRUGS4COVID, developed by the OEG-UPM (Ontology Engineering Group).

### Namespace declarations

Table 1: Namespaces used in the document
base | <http://w3id.org/eboca/sem-disnet>
metadata | <http://data.bioontology.org/metadata>
rdfs | <http://www.w3.org/2000/01/rdf-schema>
rdf | <http://www.w3.org/1999/02/22-rdf-syntax-ns>
skos | <http://www.w3.org/2004/02/skos/core>
xsd | <http://www.w3.org/2001/XMLSchema>
dc | <http://purl.org/dc/elements/1.1>
dcterms | <http://purl.org/dc/terms>
ncit | <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl>
sct | <http://purl.bioontology.org/ontology/SNOMEDCT>
wp | <http://vocabularies.wikipathways.org/wp>
sio | <http://semanticscience.org/resource>
ordo | <http://www.orpha.net/ORDO>
obo | <http://purl.obolibrary.org/obo>
owl | <http://www.w3.org/2002/07/owl>
cco | <http://rdf.ebi.ac.uk/terms/chembl>
ctd | <http://bio2rdf.org/ctd_vocabulary:>
oboInOwl | <http://www.geneontology.org/formats/oboInOwl>
xml | <http://www.w3.org/XML/1998/namespace>
bio2rdf | <http://bio2rdf.org/bio2rdf_vocabulary:>
vann | <http://purl.org/vocab/vann>
foaf | <http://xmlns.com/foaf/0.1>
void | <http://rdfs.org/ns/void>
EVS | <http://ncicb.nci.nih.gov/xml/owl/EVS>
efo | <http://www.ebi.ac.uk/efo>

## SEM-DISNET: Overview back to ToC

This ontology has the following classes and properties.

#### Classes

- A CTD association between a chemical and a disease
- Adverse reaction to drug
- annual incidence
- association
- ChEMBL Drug Indication Class
- ChEMBL Mechanism Class
- ChEMBL Substance Class
- ChEMBL Target Class
- chromosome
- concept
- Disease Marker
- Disease, Disorder or Finding
- Disease-ncRNA Association
- Disease-Phenotype Association
- Disease-Variant Association
- DisGeNET disease specificity
- DisGeNET Pleiotropy Index
- Drug Disease Inferred
- Drug Disease Marker
- Drug Disease Therapeutic
- drug drug interaction
- Drug-Disease Association
- Drug-Phenotype Indication
- Drug-Phenotype Side Effect
- Drug-Target Association
- Gene
- Gene Symbol
- gene-disease association
- geography
- group of disorders
- Organism
- Pathway
- Phenotype
- Phenotypic abnormality
- Prevalence
- Protein
- Protein-Protein Interaction
- PPI
- ProteinClass
- Score
- sequence start position
- sequence_variant
- Untranslated RNA

#### Object Properties

- Association between ChEMBL Target and Mechanism
- Causative agent of
- Cause of
- ChEMBL Drug Indication Association
- ChEMBL Mechanism Association
- ChEMBL Molecule Association
- ChEMBL Target Association
- DDI Has Side Effect
- Drug For Drug-Phenotype Indication
- Drug For Drug-Phenotype Side Effect
- Drug For Drug-Target Association
- Drug-Phenotype Side Effect Has Phenotype
- Drug-Target Association Has Drug
- Drug-Target Has Target
- Due to
- encodes
- Gene_Found_In_Organism
- Gene_Mutant_Encodes_Gene_Product_Sequence_Variation
- Gene_Product_Has_Organism_Source
- has attribute
- Has causative agent
- has measurement value
- has member
- has part
- has participant
- has target
- Indication Has Drug
- is associated with
- is attribute of
- is encoded by
- is located in
- is location of
- is measurement value of
- is member of
- is part of
- is participant in
- is referred to by
- is represented by
- is target in
- Phenotype For Drug-Phenotype Side Effect
- Phenotype Side Effect Due To DDI
- refers to
- represents
- Side Effect Has Drug
- Target For Drug-Target Association

#### Data Properties

- ATC Code
- Category
- Causality
- ChEMBL Mechanism Action Type
- ChEMBL Molecule Development Phase
- ChEMBL Substance Entity Type
- ChEMBL Target Entity Type
- Chemical Structure
- Chromosome No Version
- Concentration
- Confidence Value
- Consequence
- Disease-ncRNA Association type
- Gene Sequence
- Geography
- has value
- Inchi Key
- ncRNA Category
- Protein sequence for given ChEMBL entity
- Sample
- Sequence end position
- Sequence start position
- Strand
- Synonymous
- The ChEMBL ID for a given entity

## SEM-DISNET: Description back to ToC

Figure 1 provides a general overview of SEM-DISNET Ontology. For the sake of clarity and understanding, the diagram was designed including in each of the boxes, the DISNET label (`disnet:disnetLabel` associated with each class, along with the class identifier (`dcterms:identifier` of the original ontology, including its namespace. For this reason, the following text will refer to the classes using these attributes, although all classes are by defect described by their original label (`rdfs:label`). This diagram follows the Chowlk notation.

Figure 1 - SEM-DISNET schema for the representation of DISNET data.

SEM-DISNET Ontology is built mostly from the reuse of existing ontology concepts. Mainly, it is based on the ontology developed by DisGeNET (DisGeNET-RDF), one of the main sources used by DISNET. Other important reused concepts or Classes were taken from National Cancer Institute thesaurus (NCIT), Semanticscience Integrated Ontology (SIO), CHEMBL, SNOMED, Comparative Toxicogenomics Database (CTD), Orphanet Rare Disease Ontology (ORDO) and WikiPathways. It also reuses Object Propeties from NCIT and SIO ontologies.

The ontology schema is organized around the central classes `Disease` and `Drug`.

- Disease class

  This class was taken from NCIT and represents a condition that is relevant to human neoplasms and non-neoplasms disorders. It is specified the Semantic Type (`disgenet:UMLS Semantic Type`), the Disease class it belongs (`obo:Disease class`) and the marker it can be associated with (`ncit: Disease Marker`), including the type of sample (`disnet:sample`) and the marker concentration (`disnet: concentration`). Disease references (`sio:'is referred to by'`) to classes which represent relationships between concepts:

  - Association between a Disease and a ncRNA: although the association class was designed de novo by DISNET (`disnet:Disease ncRNA Association`), ncRNA class was taken from NCIT (`ncit:ncRNA`). Also, attributes as the ncRNA category, which refers to the classification according to HMDD (Human microRNA Disease Database) and LncRNADisease database (`disnet:category`), the ncRNA effect in the organism (`disnet:type`) and the causality (`disnet:causality)` are given.
  - Association between a Disease and rare diseases: this module was entirely reused from Orphanet database. In this case, Disease is directly related to rare disease class (`ordo:Orpha`), and the association class (`ordo:Prevalence`) associates the rare disease with its annual incidence (`ordo:Prevalence class`) specifying the geographical location (`disnet:geo`).
  - Association between a Disease and a Variant: the association (`disnet:Variant Disease Association`) has an associated score (`sio:'has measurement value'`) defined by the `ncit:Score` class. Variants (`obo:Variant`) are resources defined by attributes such as chromosome number (`ncit:Chromosome`), position (`ncit:Chromosome position`) and other parameters (`disgenet:Disease specificity` and `disgenet: Disease pleiotropy`)
  - Association between a Disease and a Gene: the same way as with variants, the association is defined by a score (`ncit:Score`). Gene class (`ncit:Gene`) attributes embraces the corresponding symbol (`ncit:Gene Symbol`), the metabolic pathway(s) to which it belongs (`wp:Pathway`), class reused from WikiPathways, and other parameters (`disgenet:Disease specificity` and `disgenet: Disease pleiotropy`). Other properties attributed to Gene entity include the sequence (`disnet:geneSequence`), the strand (`disnet:strand`), sequence start (`disnet:seqStart`) and end (`disnet:seqEnd`) positions, and the chromosome version (`disnet:chrVersion`). Gene class encodes (`sio:'encondes'`) certain Protein (`ncit:Protein`) whose sequence is present as an attribute (`cco:proteinSequence`) reused from ChEMBL ontology. Each protein also belongs to a class (`obo:Protein class`) and participates (`sio:'is participant in'`) in protein-protein interactions (`ncit:PPI`). Furthermore, both Protein and Gene classes are present in Organisms (`ncit:Organism`), and either Organism and Protein can act as a target (`sio:'is target in'`), being related to Target class (`cco:Target`).
  - Association between a Disease and a Phenotype: this association and the related class Phenotype (`disnet:Phenotype`) have been modelled de novo, since no existing classes were found in other ontologies with the meaning corresponding to the one in DISNET database. The phenotype refers to the observable and detectable signs in a patient due to the effects caused by a Disease or a Drug causing changes in their original appearence. Therefore, this class is also connected to Drug class in more than one way (explained below). Phenotypes are also associated with a specific Semantic Type (`disgenet:UMLS Semantic Type`)

The association between both central classes, `Disease` and `Drug` was reused from the CTD, the main source from which the information stored in the DISNET database is obtained. In addition, this association has been modelled de novo with three subclasses emerging from it. Drug-disease pairs are classified into these subclasses depending on the effect the drug has on the disease. A chemical that correlates with a disease or may play a role in the etiology of a disease, acting as a marker of those diseases (`disnet:Drug Disease Marker`) or it can be used to treat the disease, having a known or potential therapeutic effect on it (`disnet:Drug Disease Therapeutic`). Additionally, the association is identified as Inferred (`disnet:Drug Disease Inferred`)by an inferred score e stablished by CTD-curated chemical-gene interactions when the association cannot be identified neither as Marker or Therapeutic.

- Drug class

  This class (`cco:Drug`) was reused from ChEMBL database and represents, according to the Chemical Entities of Biological Interest (ChEBI), any substance which when absorbed into a living organism may modify one or more of its functions. The information housed in DISNET was integrated from different sources, as DrugBank, RXCUI and DisGeNET. Other de novo properties associated with Drug concept include the chemical structure (`disnet:chemicalStructure`), the inchi Key (`disnet:inchiKey`) and synonymous names for the drugs (`disnet:synonymous`). The ATC classification (`cco:atcClassification`) and the substance (or molecular) type (`cco:substanceType`) attributes were taken from ChEML ontolgy. Moreover, it references (`sio:'is referred to by'`) to classes which represent relationships between drugs and other entities:

  - Association between a Drug and a Target: this relationship (`cco:Drug Target Association`) is also known as the mechanism of action of the drug when it addresses to the Target (`cco:Target`), a molecule in the body, usually a protein, that is intrinsically associated with a particular disease to which is directed the drug. Target class has correspondence (`owl:sameAs`) with Drug Target Ontology (DTO) `dto:drug target` too, and its type is defined by ChEMBL attribute `cco:targetType`. Mechanism class data was taken from ChEMBL and DrugBank databases (`skos:exactMatch`) , corresponds with DTO `dto:drug target role` class (`owl:sameAs`) and is defined by the attribute `cco:mechanismActionType` which belongs to ChEMBL ontology.
  - Association between a Drug and a Phenotype: the relationship between a drug and a phenotype can be defined according to several criteria. For this reason, both classes (`cco:Drug` and `disnet:Phenotype`) are connected by three association classes, each of them refering to a possible causality of the interaction between a drug and a phenotype:

    - Drug Phenotype Indication: indication is the term for the approved uses of a medication. In other words, indicates the relationship of the desirable measurable effects that cause changes in a patient's phenotype and the response to treatment with a drug which is indicated to treat them. This relationship (`cco:Drug Phenotype Indication`) can be classified due to the highest development phase at which that indication has been investigated (`cco:highestDevelopmentPhase`).
    - Drug Phenotype Side Effect: describes the association between symptoms considered as adverse effects that cause patient phenotype changes in response to the treatment with a drug. This class was resued from SNOMED CT database (`sct:Drug Phenotype Side Effect`) although the data stored in DISNET database is integrated from SIDER, and also includes the highest development phase ChEMBL attribute (`cco:highestDevelopmentPhase`). In this case, the Object Properties which relate this association class with Drug and Phenotype were created de novo and classified as subproperties of the original ones taken from ChEMBL and the main SIO properties (`sio:'refers to'` and `sio:'is referred to by'`) that are used all over the ontology. This approach is specified in the boxes above the diagram, so highlighted Object Properties are subproperties of SIO and another reused ontology.
    - Drug Drug Interaction: is an interaction in which two drugs interact in such a way to produce a non-additive biological response (`sio:DDI`). The main source (`skos:exactMatch`) is DrugBank, but their redistribution is not allowed. However, TWOSIDES provides the information about the potential adverse side effects that the DDI causes in a phenotype, and it is related to Phenotype class by two de novo Object Properties (`disnet:isSideEffect` and `disnet:hasSideEffect`). Furthermore, drug participate (`sio:'is participant in'`) drug-drug interactions.

The classes corresponding to the associations between concepts (Figure 2A) were incorporated into a class hierarchy, represented as a tree independently of the main diagram for the sake of clarity, since hierarchical relationships facilitates data integration. All Association classes represented in the diagram are subclasses of the central SIO class `sio:Association`.

Example: `Gene Disease Association` is directly reuses from SIO as a subclass of `Association`, but the association between a drug and a target suits better with ChEMBL's `ChEMBL Mechanism Class`. The strategy consisted in creating a new DISNET class `Drug Target Association`, classified as a subclass of ChEMBL and SIO.

In the case of the Object Properties (Figure 2B), the objective was to make the relationships between the entities as homogeneous as possible, so, as far as possible, an attempt was made to reuse the Object Properties of SIO or, in default, NCIT. However, in cases where an Object Property was not found in these ontologies with the meaning given by DISNET, an Object Property was created de novo under DISNET's namespace and classified as a subclass of the relation of the other ontology with which its meaning corresponded and as a subclass of one of the two main Object Properties of SIO, `sio:'refers to'` or `sio:'is referred to by'`.

Example: the core class `Drug` uses ChEMBL's Object Property `cco:hasMechanism` to relate to the `Drug Target Association` (range) class, but uses SNOMED's Object Property `sct:causative_agent_of` in the relationship with `Drug Phenotype Side Effect` class (range). In order for the relationships to be homogeneous, the intermediate classes `disnet:drugForMechanism` and `disnet:drugForSideEffect` were created de novo and classified as subclasses of those of ChEMBL and SNOMED and of `sio:'is referred to by'`.

Figure 2 - SEM-DISNET hierarchies for Association Classes (A) and Object Properties (B).

## Cross-reference for SEM-DISNET classes, object properties and data properties back to ToC

This section provides details for each class and property defined by SEM-DISNET.

### Classes

- A CTD association between a chemical and a disease
- Adverse reaction to drug
- annual incidence
- association
- ChEMBL Drug Indication Class
- ChEMBL Mechanism Class
- ChEMBL Substance Class
- ChEMBL Target Class
- chromosome
- concept
- Disease Marker
- Disease, Disorder or Finding
- Disease-ncRNA Association
- Disease-Phenotype Association
- Disease-Variant Association
- DisGeNET disease specificity
- DisGeNET Pleiotropy Index
- Drug Disease Inferred
- Drug Disease Marker
- Drug Disease Therapeutic
- drug drug interaction
- Drug-Disease Association
- Drug-Phenotype Indication
- Drug-Phenotype Side Effect
- Drug-Target Association
- Gene
- Gene Symbol
- gene-disease association
- geography
- group of disorders
- Organism
- Pathway
- Phenotype
- Phenotypic abnormality
- Prevalence
- Protein
- Protein-Protein Interaction
- PPI
- ProteinClass
- Score
- sequence start position
- sequence_variant
- Untranslated RNA

### A CTD association between a chemical and a disease c back to ToC or Class ToC

IRI: http://bio2rdf.org/ctd_vocabulary:Chemical-Disease-Association

has sub-classes
  Drug-Disease Association c

Is defined by
  http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43817

has super-classes
  concept c

### Adverse reaction to drugc back to ToC or Class ToC

IRI: http://purl.bioontology.org/ontology/SNOMEDCT/62014003

has sub-classes
  Drug-Phenotype Side Effect c

### annual incidencec back to ToC or Class ToC

IRI: http://www.orpha.net/ORDO/Orphanet_409967

### associationc back to ToC or Class ToC

IRI: http://semanticscience.org/resource/SIO_000897

Is defined by
  http://semanticscience.org/ontology/sio.owl

has sub-classes
  Disease-Phenotype Association c, Disease-Variant Association c, Disease-ncRNA Association c, Drug-Disease Association c, Drug-Phenotype Indication c, Drug-Phenotype Side Effect c, Drug-Target Association c, Prevalence c, PPI c, drug drug interaction c, gene-disease association c
is disjoint with
  gene-disease association c, Disease-ncRNA Association c, Drug-Disease Association c

### ChEMBL Drug Indication Classc back to ToC or Class ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#DrugIndication

has sub-classes
  Drug-Phenotype Indication c

### ChEMBL Mechanism Classc back to ToC or Class ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#Mechanism

has sub-classes
  Drug-Target Association c

### ChEMBL Substance Classc back to ToC or Class ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#Substance

is in domain of
  ATC Code ATC Code dp, ChEMBL Substance Entity Type ChEMBL Substance Entity Type dp, Chemical Structure dp, Drug For Drug-Phenotype Indication op, Drug For Drug-Phenotype Side Effect op, Drug For Drug-Target Association op, Inchi Key dp, Synonymous dp
is in range of
  Drug-Target Association Has Drug op, Indication Has Drug op, Side Effect Has Drug op
is disjoint with
  Disease, Disorder or Finding c, ChEMBL Target Class ChEMBL Target Class c, Phenotype c

### ChEMBL Target Classc back to ToC or Class ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#Target

is in domain of
  ChEMBL Target Entity Type ChEMBL Target Entity Type dp, Target For Drug-Target Association op, is target in op
is in range of
  Drug-Target Has Target op, has target op
is disjoint with
  ChEMBL Substance Class ChEMBL Substance Class c

### chromosomec back to ToC or Class ToC

IRI: http://semanticscience.org/resource/SIO_000899

A chromosome is a molecular complex of circular or linear DNA and bound proteins.

Is defined by
  http://semanticscience.org/ontology/sio.owl

### conceptc back to ToC or Class ToC

IRI: http://semanticscience.org/resource/SIO_000326

Is defined by
  http://semanticscience.org/ontology/sio.owl

### Disease Markerc back to ToC or Class ToC

IRI: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18329

is in domain of
  Concentration dp, Sample dp

### Disease, Disorder or Findingc back to ToC or Class ToC

IRI: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057

is disjoint with
  Gene c, Score c, Untranslated RNA c, sequence_variant c, ChEMBL Substance Class ChEMBL Substance Class c

### Disease-ncRNA Associationc back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#DiseaseNcrna

A disease-ncRNA association is an association between a disease and an untranslated RNA (ncRNA).

has super-classes
  association c
is in domain of
  Category dp, Causality dp, Disease-ncRNA Association type dp
is disjoint with
  association c, gene-disease association c, Drug-Disease Association c

### Disease-Phenotype Associationc back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#DiseasePhenotype

A disease-phenotype association is an association between disease and a phenotype, which corresponds to a subjective evidence of disease perceived by the patient.

has super-classes
  association c

### Disease-Variant Associationc back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#DiseaseVariant

Association between a disease and a genetic variant.

has super-classes
  association c

### DisGeNET disease specificityc back to ToC or Class ToC

IRI: http://semanticscience.org/resource/SIO_001351

Is defined by
  http://semanticscience.org/ontology/sio.owl

### DisGeNET Pleiotropy Indexc back to ToC or Class ToC

IRI: http://semanticscience.org/resource/SIO_001352

Is defined by
  http://semanticscience.org/ontology/sio.owl

### Drug Disease Inferredc back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#DrugDiseaseInferred

Drug Disease Associations not classifed as Therapeutic or Marker which are given an associated inferred score.

has super-classes
  Drug-Disease Association c

### Drug Disease Markerc back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#DrugDiseaseMarker

Drug that acts like a marker when associated with a disease. A chemical that correlates with a disease or may play a role in the etiology of a disease.

has super-classes
  Drug-Disease Association c

### Drug Disease Therapeuticc back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#DrugDiseaseTherapeutic

Drug that has a therapeutic effect when associated with a disease. The drug is used to treat the disease in order to reduce or eliminate its symptoms.

has super-classes
  Drug-Disease Association c

### drug drug interactionc back to ToC or Class ToC

IRI: http://semanticscience.org/resource/SIO_001006

Is defined by
  http://semanticscience.org/ontology/sio.owl

has super-classes
  association c
is in domain of
  DDI Has Side Effect op
is in range of
  Phenotype Side Effect Due To DDI op
is disjoint with
  Drug-Disease Association c, Drug-Phenotype Indication c, Drug-Phenotype Side Effect c, Drug-Target Association c

### Drug-Disease Associationc back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#DrugDisease

has super-classes
  A CTD association between a chemical and a disease [ctd_vocabulary:Chemical-Disease-Association] c, association c
has sub-classes
  Drug Disease Inferred c, Drug Disease Marker c, Drug Disease Therapeutic c
is disjoint with
  association c, gene-disease association c, drug drug interaction c, Disease-ncRNA Association c, Drug-Phenotype Indication c, Drug-Phenotype Side Effect c, Drug-Target Association c

### Drug-Phenotype Indicationc back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#DrugPhenotypeIndication

Relationship between the desirable measurable effects that cause changes in a patient's phenotype and the response to treatment with a drug which is indicated to treat them.

has super-classes
  ChEMBL Drug Indication Class ChEMBL Drug Indication Class c, association c
is in domain of
  Indication Has Drug op
is in range of
  Drug For Drug-Phenotype Indication op
is disjoint with
  drug drug interaction c, Drug-Disease Association c, Drug-Phenotype Side Effect c, Drug-Target Association c

### Drug-Phenotype Side Effectc back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#DrugPhenotypeSideEffect

Secondary and undesirable measurable effects that cause patient phenotype changes in response to the treatment with a drug.

has super-classes
  Adverse reaction to drug c, association c
is in domain of
  Drug-Phenotype Side Effect Has Phenotype op, Side Effect Has Drug op
is in range of
  Drug For Drug-Phenotype Side Effect op, Phenotype For Drug-Phenotype Side Effect op
is disjoint with
  drug drug interaction c, Drug-Disease Association c, Drug-Phenotype Indication c, Drug-Target Association c

### Drug-Target Associationc back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#DrugTarget

Association between a drug and a target in order to achieve disease treatment by different action types or mechanism of action.

has super-classes
  ChEMBL Mechanism Class ChEMBL Mechanism Class c, association c
is in domain of
  ChEMBL Mechanism Action Type ChEMBL Mechanism Action Type dp, Drug-Target Association Has Drug op, Drug-Target Has Target op
is in range of
  Drug For Drug-Target Association op, Target For Drug-Target Association op
is disjoint with
  drug drug interaction c, Drug-Disease Association c, Drug-Phenotype Indication c, Drug-Phenotype Side Effect c

### Genec back to ToC or Class ToC

IRI: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612

is in domain of
  Chromosome No Version dp, Gene Sequence dp, Gene_Found_In_Organism op, Gene_Mutant_Encodes_Gene_Product_Sequence_Variation op, Sequence end position dp, Sequence start position dp, Strand dp, encodes op, is represented by op
is in range of
  is associated with op, is encoded by op, represents op
is disjoint with
  Score c, Disease, Disorder or Finding c

### Gene Symbolc back to ToC or Class ToC

IRI: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43568

is in domain of
  represents op
is in range of
  is represented by op

### gene-disease associationc back to ToC or Class ToC

IRI: http://semanticscience.org/resource/SIO_000983

Is defined by
  http://semanticscience.org/ontology/sio.owl

has super-classes
  association c
is disjoint with
  association c, Disease-ncRNA Association c, Drug-Disease Association c

### geographyc back to ToC or Class ToC

IRI: http://www.orpha.net/ORDO/Orphanet_C009

has sub-classes
  Prevalence c

### group of disordersc back to ToC or Class ToC

IRI: http://www.orpha.net/ORDO/Orphanet_557492

### Organismc back to ToC or Class ToC

IRI: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14250

is in range of
  Gene_Found_In_Organism op, Gene_Product_Has_Organism_Source op

### Pathwayc back to ToC or Class ToC

IRI: http://vocabularies.wikipathways.org/wp#Pathway

A biological process representing a set of interactions and relationships among genes, proteins, metabolites, and other factors in the context of cellular compartments, tissues and organisms.

### Phenotypec back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#Phenotype

Observable and detectable signs in a patient due to the effects caused by a disease or a drug causing changes in their original appearence.

is in domain of
  Phenotype For Drug-Phenotype Side Effect op, Phenotype Side Effect Due To DDI op
is in range of
  DDI Has Side Effect op, Drug-Phenotype Side Effect Has Phenotype op
is disjoint with
  ChEMBL Substance Class ChEMBL Substance Class c

### Phenotypic abnormalityc back to ToC or Class ToC

IRI: http://purl.obolibrary.org/obo/HP_0000118

A phenotypic abnormality.
This is the root of the phenotypic abnormality subontology of the HPO.

is disjoint with
  Protein c

### Prevalencec back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#Prevalence

Association between an oprhan disease and the incidence according to the geographical location.

has super-classes
  association c, geography c
is in domain of
  Geography dp

### Proteinc back to ToC or Class ToC

IRI: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021

is in domain of
  Gene_Product_Has_Organism_Source op, Protein sequence for given ChEMBL entity Protein sequence for given ChEMBL entity dp, is encoded by op
is in range of
  encodes op
is disjoint with
  Phenotypic abnormality c

### Protein-Protein Interactionc back to ToC or Class ToC

IRI: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18469

has sub-classes
  PPI c

### PPIc back to ToC or Class ToC

IRI: https://w3id.org/eboca/sem-disnet#Ppi

Association between two proteins by physical contacts of high specificity that occur in a specific molecular context with a certain confidence value.

has super-classes
  Protein-Protein Interaction c, association c
is in domain of
  Confidence Value dp

### ProteinClassc back to ToC or Class ToC

IRI: http://purl.obolibrary.org/obo/PR_000000001

### Scorec back to ToC or Class ToC

IRI: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25338

is disjoint with
  Gene c, Disease, Disorder or Finding c, sequence_variant c

### sequence start positionc back to ToC or Class ToC

IRI: http://semanticscience.org/resource/SIO_000791

Is defined by
  http://semanticscience.org/ontology/sio.owl

### sequence_variantc back to ToC or Class ToC

IRI: http://purl.obolibrary.org/obo/SO_0001060

A sequence_variant is a non exact copy of a sequence_feature or genome exhibiting one or more sequence_alteration.

is in domain of
  Consequence dp, is associated with op, is located in op
is in range of
  Gene_Mutant_Encodes_Gene_Product_Sequence_Variation op, is location of op
is disjoint with
  Score c, Disease, Disorder or Finding c

### Untranslated RNAc back to ToC or Class ToC

IRI: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26549

is in domain of
  ncRNA Category dp
is disjoint with
  Disease, Disorder or Finding c

### Object Properties

- Association between ChEMBL Target and Mechanism
- Causative agent of
- Cause of
- ChEMBL Drug Indication Association
- ChEMBL Mechanism Association
- ChEMBL Molecule Association
- ChEMBL Target Association
- DDI Has Side Effect
- Drug For Drug-Phenotype Indication
- Drug For Drug-Phenotype Side Effect
- Drug For Drug-Target Association
- Drug-Phenotype Side Effect Has Phenotype
- Drug-Target Association Has Drug
- Drug-Target Has Target
- Due to
- encodes
- Gene_Found_In_Organism
- Gene_Mutant_Encodes_Gene_Product_Sequence_Variation
- Gene_Product_Has_Organism_Source
- has attribute
- Has causative agent
- has measurement value
- has member
- has part
- has participant
- has target
- Indication Has Drug
- is associated with
- is attribute of
- is encoded by
- is located in
- is location of
- is measurement value of
- is member of
- is part of
- is participant in
- is referred to by
- is represented by
- is target in
- Phenotype For Drug-Phenotype Side Effect
- Phenotype Side Effect Due To DDI
- refers to
- represents
- Side Effect Has Drug
- Target For Drug-Target Association

### Association between ChEMBL Target and Mechanism op back to ToC or Object Property ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#isTargetForMechanism

has sub-properties
  Target For Drug-Target Association op
is inverse of
  ChEMBL Target Association ChEMBL Target Association op

### Causative agent ofop back to ToC or Object Property ToC

IRI: http://purl.bioontology.org/ontology/SNOMEDCT/causative_agent_of

has sub-properties
  Drug For Drug-Phenotype Side Effect op
is inverse of
  Has causative agent op

### Cause ofop back to ToC or Object Property ToC

IRI: http://purl.bioontology.org/ontology/SNOMEDCT/cause_of

has sub-properties
  Phenotype For Drug-Phenotype Side Effect op
is inverse of
  Due to op

### ChEMBL Drug Indication Associationop back to ToC or Object Property ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#hasDrugIndication

Association between the entity and a ChEMBL Drug Indication

has sub-properties
  Drug For Drug-Phenotype Indication op

### ChEMBL Mechanism Associationop back to ToC or Object Property ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#hasMechanism

Association between the entity and a ChEMBL Mechanism of Action

has sub-properties
  Drug For Drug-Target Association op
is inverse of
  ChEMBL Molecule Association ChEMBL Molecule Association op

### ChEMBL Molecule Associationop back to ToC or Object Property ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#hasMolecule

Association between the entity and a ChEMBL Molecule

has sub-properties
  Drug-Target Association Has Drug op, Indication Has Drug op
is inverse of
  ChEMBL Mechanism Association ChEMBL Mechanism Association op

### ChEMBL Target Associationop back to ToC or Object Property ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#hasTarget

Association between the entity and a ChEMBL Target

has sub-properties
  Drug-Target Has Target op
is inverse of
  Association between ChEMBL Target and Mechanism Association between ChEMBL Target and Mechanism op

### DDI Has Side Effectop back to ToC or Object Property ToC

IRI: https://w3id.org/eboca/sem-disnet#hasSideEffect

has domain
  drug drug interaction c
has range
  Phenotype c
is inverse of
  Phenotype Side Effect Due To DDI op

### Drug For Drug-Phenotype Indicationop back to ToC or Object Property ToC

IRI: https://w3id.org/eboca/sem-disnet#drugForDrugIndication

has super-properties
  ChEMBL Drug Indication Association ChEMBL Drug Indication Association op, is referred to by op
has domain
  ChEMBL Substance Class ChEMBL Substance Class c
has range
  Drug-Phenotype Indication c
is inverse of
  Indication Has Drug op

### Drug For Drug-Phenotype Side Effectop back to ToC or Object Property ToC

IRI: https://w3id.org/eboca/sem-disnet#drugForSideEffect

has super-properties
  Causative agent of op, is referred to by op
has domain
  ChEMBL Substance Class ChEMBL Substance Class c
has range
  Drug-Phenotype Side Effect c
is inverse of
  Side Effect Has Drug op

### Drug For Drug-Target Associationop back to ToC or Object Property ToC

IRI: https://w3id.org/eboca/sem-disnet#drugForMechanism

has super-properties
  ChEMBL Mechanism Association ChEMBL Mechanism Association op, is referred to by op
has domain
  ChEMBL Substance Class ChEMBL Substance Class c
has range
  Drug-Target Association c
is inverse of
  Drug-Target Association Has Drug op

### Drug-Phenotype Side Effect Has Phenotypeop back to ToC or Object Property ToC

IRI: https://w3id.org/eboca/sem-disnet#hasPhenotype

has super-properties
  Due to op, refers to op
has domain
  Drug-Phenotype Side Effect c
has range
  Phenotype c
is inverse of
  Phenotype For Drug-Phenotype Side Effect op

### Drug-Target Association Has Drugop back to ToC or Object Property ToC

IRI: https://w3id.org/eboca/sem-disnet#mechanismHasMolecule

has super-properties
  ChEMBL Molecule Association ChEMBL Molecule Association op, refers to op
has domain
  Drug-Target Association c
has range
  ChEMBL Substance Class ChEMBL Substance Class c
is inverse of
  Drug For Drug-Target Association op

### Drug-Target Has Targetop back to ToC or Object Property ToC

IRI: https://w3id.org/eboca/sem-disnet#hasTarget

has super-properties
  ChEMBL Target Association ChEMBL Target Association op, refers to op
has domain
  Drug-Target Association c
has range
  ChEMBL Target Class ChEMBL Target Class c
is inverse of
  Target For Drug-Target Association op

### Due toop back to ToC or Object Property ToC

IRI: http://purl.bioontology.org/ontology/SNOMEDCT/due_to

has sub-properties
  Drug-Phenotype Side Effect Has Phenotype op
is inverse of
  Cause of op

### encodesop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_010078

Is defined by
  http://semanticscience.org/ontology/sio.owl

Example

      an open reading frame encodes a protein (it contains information that specifies the amino acid composition and topology)

has domain
  Gene c
has range
  Protein c
is inverse of
  is encoded by op

### Gene_Found_In_Organismop back to ToC or Object Property ToC

IRI: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R41

has domain
  Gene c
has range
  Organism c

### Gene_Mutant_Encodes_Gene_Product_Sequence_Variationop back to ToC or Object Property ToC

IRI: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R178

has domain
  Gene c
has range
  sequence_variant c
is inverse of
  is associated with op

### Gene_Product_Has_Organism_Sourceop back to ToC or Object Property ToC

IRI: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R45

has domain
  Protein c
has range
  Organism c

### has attributeop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000008

Is defined by
  http://semanticscience.org/ontology/sio.owl

has sub-properties
  has measurement value op, has member op
has domain
  Disease, Disorder or Finding c or Phenotype c
has range
  Disease Marker c or concept c
is inverse of
  is attribute of op

### Has causative agentop back to ToC or Object Property ToC

IRI: http://purl.bioontology.org/ontology/SNOMEDCT/has_causative_agent

has sub-properties
  Side Effect Has Drug op
is inverse of
  Causative agent of op

### has measurement valueop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000216

Is defined by
  http://semanticscience.org/ontology/sio.owl

has super-properties
  has attribute op
has domain
  Disease, Disorder or Finding c or sequence_variant c or association c or gene-disease association c
has range
  Score c or DisGeNET disease specificity c or DisGeNET Pleiotropy Index c
is inverse of
  is measurement value of op

### has memberop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000059

Is defined by
  http://semanticscience.org/ontology/sio.owl

Example

      a collection of cars has as a car as a member

has characteristics: irreflexive

has super-properties
  has attribute op
has domain
  Phenotypic abnormality c or ProteinClass c
has range
  Protein c or Disease, Disorder or Finding c
is inverse of
  is member of op

### has partop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000028

Is defined by
  http://semanticscience.org/ontology/sio.owl

Example

      a collection of cars has as a car as a part;a car has an engine as a part; a car has a piston as a part;

has super-properties
  is location of op
has domain
  Pathway c or group of disorders c
has range
  Gene c or Disease, Disorder or Finding c
is inverse of
  is part of op

### has participantop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000132

Is defined by
  http://semanticscience.org/ontology/sio.owl

has domain
  Protein-Protein Interaction c or drug drug interaction c
has range
  Protein c or ChEMBL Substance Class ChEMBL Substance Class c
is inverse of
  is participant in op

### has targetop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000291

Is defined by
  http://semanticscience.org/ontology/sio.owl

has domain
  Organism c or Protein c
has range
  ChEMBL Target Class ChEMBL Target Class c
is inverse of
  is target in op

### Indication Has Drugop back to ToC or Object Property ToC

IRI: https://w3id.org/eboca/sem-disnet#indicationHasMolecule

has super-properties
  ChEMBL Molecule Association ChEMBL Molecule Association op, refers to op
has domain
  Drug-Phenotype Indication c
has range
  ChEMBL Substance Class ChEMBL Substance Class c
is inverse of
  Drug For Drug-Phenotype Indication op

### is associated withop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_001403

x is associated with y when x and y are logically or statistically related to one another.

Is defined by
  http://semanticscience.org/ontology/sio.owl

has domain
  sequence_variant c
has range
  Gene c
is inverse of
  Gene_Mutant_Encodes_Gene_Product_Sequence_Variation op

### is attribute ofop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000011

Is defined by
  http://semanticscience.org/ontology/sio.owl

has sub-properties
  is measurement value of op, is member of op
has domain
  Disease Marker c or concept c
has range
  Disease, Disorder or Finding c or Phenotype c
is inverse of
  has attribute op

### is encoded byop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_010079

Is defined by
  http://semanticscience.org/ontology/sio.owl

has domain
  Protein c
has range
  Gene c
is inverse of
  encodes op

### is located inop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000061

Is defined by
  http://semanticscience.org/ontology/sio.owl

Example

      A parasite in the interior of a person's intestine is located in their intestinal lumen.

has sub-properties
  is part of op
has domain
  sequence_variant c
has range
  sequence start position c or chromosome c
is inverse of
  is location of op

### is location ofop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000145

Is defined by
  http://semanticscience.org/ontology/sio.owl

has sub-properties
  has part op
has domain
  sequence start position c or chromosome c
has range
  sequence_variant c
is inverse of
  is located in op

### is measurement value ofop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000215

Is defined by
  http://semanticscience.org/ontology/sio.owl

has super-properties
  is attribute of op
has domain
  Score c or DisGeNET disease specificity c or DisGeNET Pleiotropy Index c
has range
  Disease, Disorder or Finding c or sequence_variant c or association c or gene-disease association c
is inverse of
  has measurement value op

### is member ofop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000095

Is defined by
  http://semanticscience.org/ontology/sio.owl

has super-properties
  is attribute of op
has domain
  Protein c or Disease, Disorder or Finding c
has range
  Phenotypic abnormality c or ProteinClass c
is inverse of
  has member op

### is part ofop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000068

Is defined by
  http://semanticscience.org/ontology/sio.owl

has super-properties
  is located in op
has domain
  Gene c or Disease, Disorder or Finding c
has range
  Pathway c or group of disorders c
is inverse of
  has part op

### is participant inop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000062

Is defined by
  http://semanticscience.org/ontology/sio.owl

Example

      a car is a participant in a car race; glucose is a participant in glycolysis

has domain
  Protein c or ChEMBL Substance Class ChEMBL Substance Class c
has range
  Protein-Protein Interaction c or drug drug interaction c
is inverse of
  has participant op

### is referred to byop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000212

Is defined by
  http://semanticscience.org/ontology/sio.owl

has sub-properties
  Drug For Drug-Phenotype Indication op, Drug For Drug-Phenotype Side Effect op, Drug For Drug-Target Association op, Phenotype For Drug-Phenotype Side Effect op, Target For Drug-Target Association op, is represented by op
has domain
  Gene c or Untranslated RNA c or Disease, Disorder or Finding c or sequence_variant c or ChEMBL Substance Class ChEMBL Substance Class c or annual incidence c or group of disorders c or Phenotype c
has range
  association c or gene-disease association c or Disease-ncRNA Association c or Disease-Phenotype Association c or Drug-Disease Association c or Prevalence c
is inverse of
  refers to op

### is represented byop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000205

Is defined by
  http://semanticscience.org/ontology/sio.owl

has super-properties
  is referred to by op
has domain
  Gene c
has range
  Gene Symbol c
is inverse of
  represents op

### is target inop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000292

Is defined by
  http://semanticscience.org/ontology/sio.owl

Example

      glucose is a target in the hexokinase-mediated conversion of glucose to glucose-6-phosphate.

has domain
  ChEMBL Target Class ChEMBL Target Class c
has range
  Organism c or Protein c
is inverse of
  has target op

### Phenotype For Drug-Phenotype Side Effectop back to ToC or Object Property ToC

IRI: https://w3id.org/eboca/sem-disnet#phenotypeForSideEffect

has super-properties
  Cause of op, is referred to by op
has domain
  Phenotype c
has range
  Drug-Phenotype Side Effect c
is inverse of
  Drug-Phenotype Side Effect Has Phenotype op

### Phenotype Side Effect Due To DDIop back to ToC or Object Property ToC

IRI: https://w3id.org/eboca/sem-disnet#isSideEffect

has domain
  Phenotype c
has range
  drug drug interaction c
is inverse of
  DDI Has Side Effect op

### refers toop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000628

Is defined by
  http://semanticscience.org/ontology/sio.owl

has sub-properties
  Drug-Phenotype Side Effect Has Phenotype op, Drug-Target Association Has Drug op, Drug-Target Has Target op, Indication Has Drug op, Side Effect Has Drug op, represents op
has domain
  association c or gene-disease association c or Disease-ncRNA Association c or Disease-Phenotype Association c or Drug-Disease Association c or Prevalence c
has range
  Gene c or Untranslated RNA c or Disease, Disorder or Finding c or sequence_variant c or ChEMBL Substance Class ChEMBL Substance Class c or annual incidence c or group of disorders c or Phenotype c
is inverse of
  is referred to by op

### representsop back to ToC or Object Property ToC

IRI: http://semanticscience.org/resource/SIO_000210

Is defined by
  http://semanticscience.org/ontology/sio.owl

has super-properties
  refers to op
has domain
  Gene Symbol c
has range
  Gene c
is inverse of
  is represented by op

### Side Effect Has Drugop back to ToC or Object Property ToC

IRI: https://w3id.org/eboca/sem-disnet#sideEffectHasMolecule

has super-properties
  Has causative agent op, refers to op
has domain
  Drug-Phenotype Side Effect c
has range
  ChEMBL Substance Class ChEMBL Substance Class c
is inverse of
  Drug For Drug-Phenotype Side Effect op

### Target For Drug-Target Associationop back to ToC or Object Property ToC

IRI: https://w3id.org/eboca/sem-disnet#targetForMechanism

has super-properties
  Association between ChEMBL Target and Mechanism Association between ChEMBL Target and Mechanism op, is referred to by op
has domain
  ChEMBL Target Class ChEMBL Target Class c
has range
  Drug-Target Association c
is inverse of
  Drug-Target Has Target op

### Data Properties

- ATC Code
- Category
- Causality
- ChEMBL Mechanism Action Type
- ChEMBL Molecule Development Phase
- ChEMBL Substance Entity Type
- ChEMBL Target Entity Type
- Chemical Structure
- Chromosome No Version
- Concentration
- Confidence Value
- Consequence
- Disease-ncRNA Association type
- Gene Sequence
- Geography
- has value
- Inchi Key
- ncRNA Category
- Protein sequence for given ChEMBL entity
- Sample
- Sequence end position
- Sequence start position
- Strand
- Synonymous
- The ChEMBL ID for a given entity

### ATC Codedp back to ToC or Data Property ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#atcClassification

ATC Classification Code

has domain
  ChEMBL Substance Class ChEMBL Substance Class c
has range
  string

### Categorydp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#category

has domain
  Disease-ncRNA Association c
has range
  string

### Causalitydp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#causality

has domain
  Disease-ncRNA Association c
has range
  string

### ChEMBL Mechanism Action Typedp back to ToC or Data Property ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#mechanismActionType

Type of action of the drug on the target e.g., agonist/antagonist etc (foreign key to action_type table)

has domain
  Drug-Target Association c
has range
  string

### ChEMBL Molecule Development Phasedp back to ToC or Data Property ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#highestDevelopmentPhase

The highest phase the molecule has reached in drug approval process (4 = approved)

has domain
  Drug-Phenotype Indication c or Drug-Phenotype Side Effect c
has range
  integer

### ChEMBL Substance Entity Typedp back to ToC or Data Property ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#substanceType

ChEMBL Substance Entity Type

has domain
  ChEMBL Substance Class ChEMBL Substance Class c
has range
  string

### ChEMBL Target Entity Typedp back to ToC or Data Property ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#targetType

Describes whether target is a protein, an organism, a tissue etc.

has domain
  ChEMBL Target Class ChEMBL Target Class c
has range
  string

### Chemical Structuredp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#chemicalStructure

has domain
  ChEMBL Substance Class ChEMBL Substance Class c
has range
  string

### Chromosome No Versiondp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#chrVersion

has domain
  Gene c
has range
  string

### Concentrationdp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#concentration

has domain
  Disease Marker c
has range
  string

### Confidence Valuedp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#confidenceValue

has domain
  PPI c
has range
  string

### Consequencedp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#consequence

has domain
  sequence_variant c
has range
  string

### Disease-ncRNA Association typedp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#type

has domain
  Disease-ncRNA Association c
has range
  string

### Gene Sequencedp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#geneSequence

has domain
  Gene c
has range
  string

### Geographydp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#geo

has domain
  Prevalence c
has range
  string

### has valuedp back to ToC or Data Property ToC

IRI: http://semanticscience.org/resource/SIO_000300

Is defined by
  http://semanticscience.org/ontology/sio.owl

has characteristics: functional

has domain
  Score c or Gene Symbol c or sequence start position c or chromosome c or DisGeNET disease specificity c or DisGeNET Pleiotropy Index c or annual incidence c or Drug-Disease Association c
has range
  double or integer or string

### Inchi Keydp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#inchiKey

has domain
  ChEMBL Substance Class ChEMBL Substance Class c
has range
  string

### ncRNA Categorydp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#rnaCategory

has domain
  Untranslated RNA c
has range
  string

### Protein sequence for given ChEMBL entitydp back to ToC or Data Property ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#proteinSequence

Protein sequence for given ChEMBL entity

has domain
  Protein c
has range
  string

### Sampledp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#sample

has domain
  Disease Marker c
has range
  string

### Sequence end positiondp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#seqEnd

has domain
  Gene c
has range
  integer

### Sequence start positiondp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#seqStart

has domain
  Gene c
has range
  integer

### Stranddp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#strand

has domain
  Gene c
has range
  integer

### Synonymousdp back to ToC or Data Property ToC

IRI: https://w3id.org/eboca/sem-disnet#synonymous

has domain
  ChEMBL Substance Class ChEMBL Substance Class c
has range
  string

### The ChEMBL ID for a given entitydp back to ToC or Data Property ToC

IRI: http://rdf.ebi.ac.uk/terms/chembl#chemblId

has domain
  Drug-Phenotype Indication c or Drug-Phenotype Side Effect c
has range
  string

## Legend back to ToC

c: Classes
op: Object Properties
dp: Data Properties

## References back to ToC

Add your references here. It is recommended to have them as a list.

## Acknowledgments back to ToC

The authors would like to thank Silvio Peroni for developing LODE, a Live OWL Documentation Environment, which is used for representing the Cross Referencing Section of this document and Daniel Garijo for developing Widoco, the program used to create the template used in this documentation.