diff --git a/SEM-DISNET Documentation/index-en.html b/SEM-DISNET Documentation/index-en.html
index c81fcfc3ce0d64d7c7cbda548c0660b9e0ba51db..0b970d641a8e64d7a6e126df79beb08c5551b5c5 100644
--- a/SEM-DISNET Documentation/index-en.html	
+++ b/SEM-DISNET Documentation/index-en.html	
@@ -55,7 +55,7 @@
    <div class="head">
       <div style="float:right">language <a href="index-en.html"><b>en</b></a> </div>
       <h1><b>SEM-DISNET</b></h1>
-      <h2>Release 2022-03-30</h2>
+      <h2>Release 2022-06-10</h2>
 
       <dl>
 
@@ -585,7 +585,7 @@ This ontology has the following classes and properties.</span>
             as an attribute (<tt>cco:proteinSequence</tt>) reused from ChEMBL ontology. Each protein also belongs to a class
             (<tt>obo:Protein class</tt>) and participates (<tt>sio:'is participant in'</tt>) in protein-protein interactions
             (<tt>ncit:PPI</tt>). Furthermore, both Protein and Gene classes are present in Organisms (<tt>ncit:Organism</tt>),
-            and either Organism and Protein are can act as a target (<tt>sio:'is target in'</tt>, being related to Target class
+            and either Organism and Protein can act as a target (<tt>sio:'is target in'</tt>), being related to Target class
             (<tt>cco:Target</tt>).</li>
          <li type="circle"><b>Association between a Disease and a Phenotype</b>: this association and the related class Phenotype
             (<tt>disnet:Phenotype</tt>) have been modelled <i>de novo</i>, since no existing classes were found in other
@@ -597,14 +597,13 @@ This ontology has the following classes and properties.</span>
       </li></p>
       <p>
          The association between both central classes, <tt>Disease</tt> and <tt>Drug</tt> was reused from the CTD, the main
-         source from which the information stored in the DISNET database is obtained. However, this class has (<tt>owl:sameAs</tt>)
-         an associated class in SIO (<tt>sio:'chemical-disease association'</tt>). In addition, this association has been
-         modelled <i>de novo</i> with two subclasses emerging from it. Drug-disease pairs are classified into these subclasses
+         source from which the information stored in the DISNET database is obtained. In addition, this association has been
+         modelled <i>de novo</i> with three subclasses emerging from it. Drug-disease pairs are classified into these subclasses
          depending on the effect the drug has on the disease. A chemical that correlates with a disease or may play a role in
          the etiology of a disease, acting as a marker of those diseases (<tt>disnet:Drug Disease Marker</tt>) or it can be used
          to treat the disease, having a known or potential therapeutic effect on it (<tt>disnet:Drug Disease Therapeutic</tt>).
-         Additionally, the association is identified by an inferred score established by CTD-curated chemical-gene interactions
-         (<tt>sio:'has value'</tt>).
+         Additionally, the association is identified as Inferred (<tt>disnet:Drug Disease Inferred</tt>)by an inferred score e
+         stablished by CTD-curated chemical-gene interactions when the association cannot be identified neither as Marker or Therapeutic.
       </p><p>
          <li><b>Drug class</b> <p>This class (<tt>cco:Drug</tt>) was reused from ChEMBL database and represents, according to
          the Chemical Entities of Biological Interest (ChEBI), any substance which when absorbed into a living organism may modify
@@ -642,7 +641,7 @@ This ontology has the following classes and properties.</span>
                   is specified in the boxes above the diagram, so highlighted Object Properties are subproperties of SIO and another
                   reused ontology.</li>
                <li type="square"><b>Drug Drug Interaction</b>: is an interaction in which two drugs interact in such a way to
-                  produce a non-additive biological response (<tt>sio:DDI</tt>). The <m></m>ain source (<tt>skos:exactMatch</tt>) is
+                  produce a non-additive biological response (<tt>sio:DDI</tt>). The main source (<tt>skos:exactMatch</tt>) is
                   DrugBank. However, TWOSIDES provides the information about the potential adverse side effects that the DDI causes
                   in a phenotype, and it is related to Phenotype class by two <i>de novo</i> Object Properties (<tt>disnet:isSideEffect</tt>
                   and <tt>disnet:hasSideEffect</tt>). Furthermore, drug participate (<tt>sio:'is participant in'</tt>) drug-drug