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SEM-DISNET
Commit e050ebe6 authored by Andrea Alvarez Perez's avatar Andrea Alvarez Perez
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SEM-DISNET Documentation/index-en.html
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...@@ -677,6 +677,275 @@ This ontology has the following classes and properties.</span> ...@@ -677,6 +677,275 @@ This ontology has the following classes and properties.</span>
<img src="SEM-DISNET_hierarchies.png" alt="General overview of the SEM-DISNET Ontology Class and object properties hierarchy" width="90%"> <figcaption><b>Figure 2</b> - SEM-DISNET hierarchies for Association Classes (A) and Object Properties (B).</figcaption> <img src="SEM-DISNET_hierarchies.png" alt="General overview of the SEM-DISNET Ontology Class and object properties hierarchy" width="90%"> <figcaption><b>Figure 2</b> - SEM-DISNET hierarchies for Association Classes (A) and Object Properties (B).</figcaption>
</center> </center>
<div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" id="example">
<h3 id="example-headline" class="list">Example</h3>
The following example shows annotated data with EBOCA SEM-DISNET module. The example shows an association between a gene (<tt>:gene-5979</tt>) and a disease
(<tt>:dis-Multiple%20Endocrine%20Neoplasia</tt>), as well as all the attributes related to such association (<tt>:orpha-Multiple%20Endocrine%20Neoplasia</tt>,
<tt>:DSI-gene</tt>, <tt>:chr</tt>, <tt>DPI-gene</tt>, <tt>:wp-WP2586</tt>, among others). Also shows certain variant (<tt>:var-rs121913306</tt>)
of the aforementioned gene. The example describes a concrete association of that disease with a specific drug (<tt>:drug-CHEMBL30%20Multiple%20Endocrine%20Neoplasia</tt>).
This specific drug interacts with a target (<tt>:target-CHEMBL1941%20CHEMBL30%20Prot%20P07949</tt>) through an association (<tt>:dtassoc-CHEMBL1941%20CHEMBL30</tt>),
which, at the same time, is target of a protein (<tt>:prot-P07949</tt>) and an organism (<tt>:org-9606</tt>). The drug can cause three specific phenotypes when treating
the disease, depending if it acts like a therapeutic (<tt>:phenotype-indication%20C0002736</tt>), with association <tt>:dpassoc-indication%20CHEMBL30%20C0002736</tt>;
marker (<tt>:phenotype-sideeffect%20C0001824</tt>), with association <tt>:dpassoc-sideeffect%20CHEMBL30%20C0001824</tt> or due to the interaction with another drug
(<tt>:phenotype-ddi%20C0003467</tt>), with association <tt>:dpassoc-ddi%20CHEMBL30%20C0003467</tt>.
<pre>
@prefix : &lthttps://w3id.org/eboca/sem-disnet#&gt .
@prefix owl: &lthttp://www.w3.org/2002/07/owl#&gt .
@prefix rdf: &lthttp://www.w3.org/1999/02/22-rdf-syntax-ns#&gt .
@prefix xml: &lthttp://www.w3.org/XML/1998/namespace&gt .
@prefix xsd: &lthttp://www.w3.org/2001/XMLSchema#&gt .
@prefix rdfs: &lthttp://www.w3.org/2000/01/rdf-schema#&gt .
@prefix ncit: &lthttp://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#&gt .
@prefix obo: &lthttp://purl.obolibrary.org/obo/&gt .
@prefix ordo: &lthttp://www.orpha.net/ORDO/&gt .
@prefix cco: &lthttp://rdf.ebi.ac.uk/terms/chembl#&gt .
@base &lthttps://w3id.org/eboca/sem-disnet#&gt .
:gene-5979
a &lthttp://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612&gt ;
rdfs:label "Gene ret proto-oncogene" ;
rdfs:comment "Gene associated with disease Multiple Endocrine Neoplasia" ;
:chrVersion "NC_000010.11"^^xsd:string ;
:seqStart 43077069^^xsd:integer ;
:seqEnd 43130351^^xsd:integer ;
:strand 1^^xsd:integer ;
:geneSequence "AGTCCCGCGACCGAAGCAGGGCGCGCAGCAGCGCTGAGTGCCCCGGAACGTGCGTCGCGCCCCCAGTGTCCGTCGCGTCCGCCGCGCCCCGGGCGGGGATGGGGCGGCCAGACTGAGCGCCGCACCCGCCATCCAGACCCGCCGGCCCTAGCCGCAGTCCCTCCAGCCGTGGCCCCAGCGCGCACGGGCGATGGCGAAGGCGACGTCCGGTGCCGCGGGGCTGCGTCTGCTGTTGCTGCTGCTGCTGCCGCTGCTAGGCAAAGGTGAGTTCTGCCGGCCGCCGGCTCCCGCAGGGGCCAGGGCGAAGTTGGCGCCGAGCAGCGGAGCGGGCGCGTTCAGAAGCGCCTTTCTGTTTGCCGTGGGCAGCGGGCTGTGCGGTCGCCGGCCACCCGGCCTCGGCTGGGAGCGCAGTGGCTGCGGCGGGCGGCGGGCGAAGGGCAGGACGCCTCGGGCCGGGCGCCTCGGGCCGGGGCTGGGCGGGTCTCGGGCGGGAGCGGAGCGCGGGCCGGGCCGCGGGGGTCGGTGCTCAGAACCCTAGCCATAGCCGCAGGTCTCAATCTGGCCGCGCCCTGCGCCAAAGCCGCGTCCTGGAGCAAACGGGACAGCCGTTTCGGGGCCGACCTGGCGGACGGGTCAGGGAGCCCCGAAAGCCCGCGATTCGTGCGGAGAGTTCTGTTTCGGCAGGAGACGGCTCCGTCCTGGTTTCCTTTTCCCGCTCAGCGTCCGTGCGTTCCTCCCCCAGCTCTGCCGTCCTGGCCAGCCGAGGGATTCGGAGGCTCTTTTGAAAAGATTGCTTTTCCCTCGTGCGTTTTTGCCGCCCTGTCTTTAAACACCTAAAAACCGTGGTTTCTGGGGTGGCTCCCCCCGAGGGGCCGCCGTGATAGGCGTCCCACCCGGCAGCCCTGGAGTCGTGTGGCGCTGCCTGGCAGAGATGCTGAAGATGCGGCCATAGGAGGCCCAGGGCTTGGGGTGGGGCAGGGGTTTGCGCCGCCAGCCAGCGTTGGTGCTGGGCCTGGTGAAACCTCAGGTGCCTTAGGATCCCAGCATTAGGTGTGGCCTTGCAAAGATGGTCATCGACCCCACCCAAACTCTGGCAGAGTGAGCCGCAAGGCTGTGGAATCTTTGACCCCTTGGCACGCGTTTAAGTGTCCCTCAAACTGGCCCTGACTTGATCCCCTCCAAGCGCTTGTGTATGAACCAAGTTTCCCTCTAAGAGGGAAGGAGCCCTGGCCATCCTCCCTCACTCCTTACAAAGGGCTTTCTCTCCCCACAGCCTTTGGGAACAGAAGAAGCCATGGTCAGTCACCCTGTCTCTGGCCCCAGGCCCTGCACAAACTGAGTTTCCAGGCCTGCCTGAGACTTCATTTGTGTGACCTGCGCCTCAGCTCAGCATATGCTGAGGCCAGAGCGGGTCCCCAGTCCACCTAGCGAGGGACAGGGGAGAAGCCCTTGCCTTTCTATCTTTTCTGAGTGTTAGGACTTTGGGGTCCCAGTGCTGCAGGGGGAAGACACGGGGCAGAAGCAAACAAGGCGCTCTGACGCTGTCTTGGGATTCTGGGCTGTGGCTTTGGCTTTGAGGTTGTGGGCAGGGGGCCAGGTGTGAACTGCTGCTGGTGTGCTGGGCAGAGGACTTCCCCACACCCTTCCACAGCCTTGCGTTCAGTTGGGGTGGCCAGTGAGGCTGTGGGGGCCAGGCTCTGGGGGCCGGCTTGTGGCACTCAGCAGGCATGCAGGTAGCTTTCCGTGCCCAGACCCCTGGCCCACAGACAGCTTCCCGAATCCAGAGATGGTGAGCCCCTAGCCCCTGGGATAACCCGGACACCACAGTTGGAGGCACTGGGAGTGAAGAGGCAGCCCCACTCCCTGGAGTAGACAGCTGGGGCCTTTGAAGAGGCTGCAGAGCTCTTTCCCAGGAGCCACAGCTCCGGAGGTTCGAGCCGCACTCTTGGAGCTGCCAAGGACCGCCCCAGTGAGCCCCTCGGTGCTCCCCAACCACCCCAAGGGGACAGCTCGGCCTCAAGCGCCCTCTTGCGGACGCTGCACTTTAGTGGCTGGGCCTGATGACAGGCACAGACTGGGTCTCTAGAGGATGAGGGTTCTTCCACAGCTCACACATGCACACTCACACTGGATCACCAAGACACACTCCTGCCCCTTCTCACAGCACTTGCTGCCAAGGCTGTGGACATGCACAGCGTGGTTCCTTCACACCCTGCCTCACCCACGTCCACACAGGGACCCCAGCCCCTCTCATCACTCATACACACAGGGACGCCACGTGTGTATATAGGGACACACACTCCTCATACCTGCAGGGCATAGCCTGTCAGCCCCAGGTATGCTGGAACCAGAGTGAGAGAACCTCCATCTAAAAGTTACATTCATTTAAAAGTTGCTCTTAAAGGTTTCTGGCATTTCATTGCTCAACACAGATACAGCTGTCCCCGTTGCTTGGATGAGGAAACTGAGTCTCAGCTTCTGGGGTTCCCCCCAGGTCCCAGGCTGACCCTGCACCTCAACCTCCCACAGCTCCTCAGCAAGCCTCTTGTCTCTTGTCTTCCTGGCCTGACTTCTTGGGTCCTGTTTTGCAGCAAGGAAGGACATTCCCTCTCTGCCCCTGGGCCCCGGGGCCTTCTGTTCCCAGCATGGAAGAGCTGGGCACTGTGACTTGGCAGGGCCCGGATCCAAGCTGCCAGACCACCCTCTGCAGAGGGCCTAGGCAGCCCACCCCTGCCTGAAGCACCAGGTATCAGCGCGGGCAGCTCAGGCCAGGGGTACAGCTCCCCCTGCTTCATCCTTTTCCTTCTCCCCTTTCTCTGGCCAGAGGCTTCACCAGGTTCACCTGGGCCTGGCTTGCTTCCTCCTCCACTCCAGCTCACTAACCCTGTCTGGCCTCCAGAAGCTGCCTGCAGCCCTCACTGGTGGGCTGTGCCTGCTGGGGGCCTGCAAGCAGAGAGCAAATGGGGAAGTGCATTGAGCTGATTCACTAAATTGCCTTTCTTCTGCAGAATCACTTTAGGGACAGGCTGAGGAAATCACTGTTTCCTTGGTGGTGTGAAGAAAATGGGATGCGATCACCTAGCGGGGAGCTAATAGCCTTTTAGCCAGTGGAGGAGAAAACCAATTAAAAATTATGATATCTGTTAAAATGGAACCTGGGGTGCCAAGGGGAAGGGAAGGCCCGGAAGCTGCCATCTCCCCTGAGACCTTCCCCCTCTGCAGCCTGGCCGAAGACCCTCTAGGTCCCCTCGTCTTAACTGGATAAGGCTAATACCAGCAGTAGCACCCCATGGGGGCTCACAGTGCACTGCCCCTGTGCTGTGCCTACTCACTTCATCTTTTCCAACAAGTCTGCAAGGGTCATGGTCTTGGCCCATTTCACAGGTGAGGAAACAGGTTCTCATAGCCTATGGACTCGAACCGGTAGAGAGGATGCGGGAGCTCCCCAGCCCTGGCCCTCTGGCTTGCTCCAGCCCGTTCTCTGGGCCAGTGGTGTGGGTCCAGGGTGGGGCTAAGGAGGGCTTCCAGGGAGGTTGCCCTGAGCCTGCCCACCCACTGGTGAGTCCCCCCACCTCGGGCTCCAGGTGCCCTCAGGACATCCCAGCCCAGATCCCAGAGTAATGTGTGGCACCATGCACAGACGCTGAGATACTCTCTGGGTCTCGTCAGCTTTAGTTGATGTCTGGGAGTCCTATGGGTCTGGGGAGGAGCACCAGGCATGGCTGTGCCAGCAGAAGGGCCGACTGTGTGTGCTCTGTGGATGGCAGGAAGGCATCTTGCTGCCAGTGGCGGTGCAGATGTTCGGCTGGGACACCAGGCTGTGGCCCTTGCAGCCAACATATGCCTGAGGCCCTGGCATCGGATGGAAGCTACTGCTCTGAAGACAAGGGTGCAGGGATGGGGTTTGGGCATCAGGGATGGGGGTACAGCTGTGTTTCCTCATGCAGGACAGGGCCTTCCTCCTCATTTTTCCCATCCTCCAGGACAGCCTGGGAGAAGAAAGCCAGGGAATAGGGGCAAAGCAGGGTGCAGCCCCCCATGCTCCCTGCTGCCCTCCTCCCCTCCTGCAGAGGCACTTCCTTTCCACTTCAGGAGCCCCTCCCCCAGAAGTGGGCCCCCCCCATCCCCCCTTCCTTCTTTGGAGGCTGCTTCCTGGTGCCAGGTTATGCTCCCTCCCCGTTCTCTGCTGTGCCCTCTATCTCCCCACTCCTCTGCAATTATTTTTCAGCAGAGTGACTTAATAGTAACAATAACAGTAACAATAATAGTAACAACAGCAGGCTGGGAGCACTCCTGAGGGAGCCTCGGCTCCTGCCCTGCTGCTCTAGGGCTGGGGACTCTCCAGAGCTGTCTCATGGCAGGGAGAGACCGTAGTCAAGGAGACCCTGTGTAGGGACTTCCGCATGCGTGTGTGGCAAGGGGCGGGGACTGGGCAGTGACCACCAGGCAGGGAGCACACCTCAGTCATGGTCACAGAGAAGGTGATGATGGCACCAGGGCTGTCTCTCCGTGCCCGTCTGCACCTGGGCCTGCCAGAGCCGTCTTCTGTGCCCCATGGGGTAGGGGAGCACCCCATGGCCCCTGGGAGGCTGCCAGTCAGTGGGACTATGAGGTCAAATGGGGAGGTCCCTTGGGGTCCATGACCCAGGCACTGCACCCCTTGGGGCTGGAAGGGGAGAAGGCCCCAGGCCCACCAGAGCCCCTCTGGCTCCCCCACTAGAACAGCAGCCAGGGCCGGCTCAGGGATTGAGGCGAAGCCTTGGTGCTTGATTCTTTGTCCCCTGAGGCAGGCTGTACCTCTCATAGGAGAACTTTGGAGGACGGGCCTTCTCCTGACCAAGGCTCTGGGACACTTGGCAGCCCCTGAGGTCCTGCTTTACCTCTCTGCTTTCTCCCCCCTTCTCTGAGCTCTGGGGCCAGGCCTGGGCACTTGGATTGGCGCTGAGACAATGAGGCCTGAACCTCCATGGAGCTCTGGTCCCGCAGCTGTGTGATCATGGGGGCCTCAGGGACCCCGCTCCCCTCCATTCCCCAAGCCTAGAGGCCATGAAGCCTGTGGGTCCCTGAACTGTCCACCCTGAGACTGCAGGCAGGGCAGGGCTGGGCAAGAGCAGGCAGCAAGCTGTCCTTGTTCCCACAGCTCCTCCTGGCTGGGCTCTTGGCCCCTGAAAAGCCTGGGGCAGGGAGATGGTGCCAGCAGGACCTTAAGGACAGCAGTTCAGGTCGCACCTGGCCCTGGAGGGAGCAGGTGGCCAGCTCCAAGCAAACACCTCTGTTTGCTTTTGCCTCAAGGAGTGGCTCCACAAAGTGTAGCAGCCCAGGCACCACCACAGAAAGGTCACCGCTGCACCTGGACAGGTGTGCGCCTACCTGGTGGACCAGCGGGCATAGGCTTTCCTCCCTGATATCAGGGATACCTGGAGGGCCTGGTGCTGGGGCTCTGTGCTCAGGGGAGAACCTGTGGCCCTACAGCCCCAGGTTCTAGACCCCCTCCCAGATTCGGGTGCTGCAGCTGCGCTTCCACTCCTGGCCCTTGCTCCTCTGTGCTGCTGCTCTCCATGCCCTGCAGGAGCCAGGGTTCCAAGGAAGCACCTGAGGGGCAGTGTGGCCCCAGGGCAGGAGCAGGACAGTGGCCACCAAGCTGTTTCCAGTTCCCTTGTGTGCCTGTGACTCCAGAGGATTCTCGCCCTTGTGTTCCTGAGAGGGAAAAAGGAAACATGTATTTCCTAGAATTTAAGTAATGACTGGGGAGATGTGTGCTCTGGGTGCCGGGACGAGGGTGGGTGAGCTGGAGGTGCAGCATGAGCTGGTGCAGTTCTGGAGGGAGGGAGAGGGCTCATTGGGTTTCTTCCTCATACTACTTGGCAGTGCAACTGGCACAGACCCGGCAGCTGTTGCTGGGCTAGGGGCCAGGGGCTTCCTCTTGCTCTGTTCCCCTTCCTGCTCCACCACCATTGCCTGTAGGGCGTCTGCCAGCCCCAGGAAGCCTAACACTTAGCCCAAGTGGGGCTCTGGGCCTGGCCCTCCTCACCCAGGGAAACAACGGGGCTCATGGGCGCTTGGTGACATGGGCACATTGCTCTGCCATCGTAAGGGGCCAGCCTGGCTATGGGACCCAGCACCGGTGGGCAGCCCACAGGTTGTCTCTGCAGGAGACTCCTCTGGCAGGTCACATACAGGATGCCCCACAGCACCTTGAAAACTCGTGACCCGGGAAAGCCTCAAATTGTCTTTGCTCCCCTAGCCTCCCCACCACCTGTATATGCAGGGGCATGTGAGACTGTACTTGGTGACAGGAATGCCCCCCAGTCTCAGGGGCTTAACGCCATCTACTATGTCCTTCTTGTGGCATAGCCTGGCATGGCCCTTACCCACTGGGTGGCCACACCTCCCAGCCCTTGTGCCTGGCTATGTGCACAGGAGGGCACAGAGCTTCAAGAAGCCTGAGGCTTAAGGAGCTTTGAGGCCTGGGAGGGGGCCACCGTCACTTTCCCTGTGTTCCGTGGGATCCTGTCACATGGTCGTTCTCACCCCAGGAGGCTTCAAGTACAGAGGACGCGGGGATGGGGGCACGCAGGGGTGTACCTGCACACACTTCTGCCTACCAGCTCTCCATCCCTTGTCCTGGTCCACATAGCAGGGGCTCCTGGCGGGCCCAGCAGCTGAGGGGGACAGAGGGGGAAACAGGGTAGCAAATAATTATGGTTTACTCTTTTTTAATTGTGAAATTTGTGTAACATAAGTTTAACCATTTATAAGTGAACCATTTGGTGGCATTTAGCACATTTACAGCATTGAACAGGCATTGCCTTAGTTCCAAAAAATTTGCATCACCCCAAAAGGAAACCCCATACCCATTAAACAGCTGCTTCCTGTCCCCGGGCAACCCCCAGCCTGCGTTCTGTCTCTGCGGCTTGGCCTGTCCTGGAACATTTCATCTGCATGGACTGTTGTCTGGCTTCACTCAGCATAAGGTCTTCAGGGTTCCTCTAGGCTGTGGCACACATCAGCCCCTTCCTGTGAGGGGTAAATAGTGTGCCGTCACCCATTCATCTGGGGATGGACACGTGGGTGCTTTCCACCTTTTGGCAGTTATGAAAAATGCTGCCAGGGACATTCCTGTTATAAATACCTGAGTTCGTGCTTTCAGTTCTTTTGGGTACATACCTGGACATGAAATCGCTAGGTAATTCTGTTTTATATTTTGTGGAGCCGCCAAACTGTTTTCCACAGTGGTTGAATTGTGTTACATTCCCAAGGGTTACAATCTATCCACATTCTCACCACCACGCATTATTCTCTGTTATTCTCTGGTTCATGTCTCACTCTGGCCGTGCAGCCAGTGCACAGTGCTAGCTCGTTGTGGCTTTGGTTTGCCTTTCCCCGGTGATGGCGTGCTGGGCATCTTTTCCTGTGCATGCTGGCCAGTTGCATGTCTCTTTGGAGAAGCATCTCTTCGAGCCCTCTGCCTGTTGTCTAACTAGATGGCTGTCTTGCCATACAGCTGACTTTGCTGTTGCATCTGCATCAAGAGCTGCAGAGAAGCAGCTTTATCCAGGGCCGTCACTGTCAGTGATTGAGCCCCAGGTCCCTTGTGAGGAGAGTGTGGATTCGTCTGATTCCTCACATGGGCATTGAATCACCACTGCCCTCGAGGACCTTGAGGACATTCTCGGAAGACCTGGACTCTGAGGCCACGTTGAGCACCAACATCTGGAAACCATGGTGTCACTGCTTGTGCATAAGAAGGGGCCTCTCAGGAACCGCCCTGTGAAGGATGGAGGAAGGGGAAGGTGCAAGGAGCCAGCAGACCCCCACCCCACTGACAAGACGAGACTCAGCAGCAGGGGAACCAGGGCCGCCCTCTCTCGCTCATCCTGAACCCTGACTCTAAAAATAACCAGGCTGATAATCGGATCCGCTGTAAGTTGATTATCATCATTGCCGTGGTGTGATGTCATGCTGCCAGGCCCTGGGGCAGTTTTCTCAGGACAGCGGTGGATGCACCTAGGCAGCTCTGGAGGCCAGCATGGAGCTGGGGGGCCCTGAACCGAGGGTGGCAGGCAGCCTCTGTGGGCTCCTGCAAATCTGCTTGGTGGGGGTGGAACACTGGCATCCATAGGCAGGCACTCTGTGCTCCCAAGGAGGAGTTCCTGTCCCCATTCGCAGCTAGGGACAGAGCCAGGGAAGCCAAGTGCCCAGCCCTGGCAAACAGCGGGGAAGCACAGGGGCATGGGCTGGGCCGCTCTGCCCTGCGTTTCTGCTCCTTCCTGCTGCTGAACTCTCTCCTTTCTGCTGCTGAACTCTCTCCTTTGGACTAGGCCTTTGTCTTCTTGCCTCATCGTCAGTGGCCTGGGAGGACACTTGCAGTCTTAATCCTGTTTTGGCCCCATGTCCCTCACCCCCCAGGGGCCACCTAGGCCAGAGCCTGTCCTGATTTCCATCTCGGCCACCGTCTGCCCCTCGGCCCCTGGTCAGGAGCTCATTCTGTGGATACTCCTGCATAGACATCACGTGGACTCAAAGGGCATGAGGACCTCGGCTGAGAGGAGCTTACACATCAGTGCAAACCTCTCATTTTACACAGGGAGAAATCGAGGCCCTGAGGGAGGCGTGAGTTGTCACACATGGGGGTAGTGTCAGATGAAGACTTGGCACCACTTCCCTGGGCATCCCCTTCCCTGCATGGCATCCCCAGCCTTGGGTTTGGATTCTTCTTCACCCTTGATGTTGAGGTCTTTGCTCCCAGGACCTGGATAACAGCATCCAGATGCAGGTGGTGCCCCCGCATCGGGCTGCCTGGCTGTGACCTGGGGCATCAGGATTGTCAGCTTGTCTGGCCCCAGGTCTGTGCTGGGCTGAAACCTACTGTCTCAGAGGCTCCTGGCTCTCTCCCTCTGCTCTCCACTGCTCTTAAGAGCAGACCCTCAAGCCTTTTTTGTGTCCTCTCTCCAGGGAGAGCCCAGCTTCTACTCTGCAGCCCAATGCAGAAGGGGTGGTAGCTCACGGTGCCTCGGCTTCTCTGCATGCCTGTCACTGAACAGAGAAGCCCAGGCCAGACTGCAGCTTAATTCCTAGCCTCTGTGTGGCCTCCAGCAGGGTACCTAAGCTAGTGCTGCCTCATTTTCCTCCTGTGTGAGATGGGAATCCTCATGGTCCCTACCTCTGACAGTTGTTTTGATGCAGTGGGTGATGCAGATGAAGCGCCCGGAGCAGACCTGCTCATGAGGAGCACACCGTGGATTCCTACTGGTTAATGTTGAACAGGGATGAGAAGGGGCTGGGGTAGGGCGAAAATGGGCAAGACCATCTCAGCTTGAGGAACATGAGCTGACAGATTGACTTAAATTTGCACATGGACATGATCTGAGTCACTGCCTTGCTGAGTGCATGGGGACAGTTGCCCAGGCCAGAGGCACCAGGGTCAAAGCCAGTGGTGATGCCCTGGCCCCGTTGCCCCAGGCCAGGGCCAGTGAACAATGTAATCAGCTGGGGCAGACTCTACAGCCCTGCAGCCAAGGGGGCCAGTGACCCTTACATGGTCATCCACAGGCCACTTGGGTGGCCAGTCCTGTTCAGCCAGGCCTTGCCCTAGGAAAGAAATTAATTATAACCTAATTGGCAGTTTCCTTTGCATAGAAGCCGGAAGCAACTGCCAGTGAGGCTGGTGATTAACTCTGCAGCAGCTGGGAAATTGCAGTTGGGCAGGAGCGCCCATCATCCTGGCCAGGCCGCTGCAGCTGGTCTGGGTATGGAAGTGTGGGTGGTGGCCATCGTGCAGCTTAGGGCCTGGGCCCCTCAGAGCAGAAGGCTGGGTCTGTGTGCAGAAGGTAGCCTTGGGCTGCCAGGTCCCCCAGTGCCCAGTTGCGGACCTCCTTCTCCCAAACCTCAGCCATGCCTGGACCCCTTCCCCACTCACGGCAGAAGGCTGCATGGCTTTTAGGGGTGTCAGGAGGCTCATGTCCTGGTTGCAGTTCTACCATGGGTGTGCAGCGGGAATTCTGGGCTTCTGTTTTCTGGCATGGGATGGGGTGAATGATATCTCTGTTCTACAGCAGGGGCTCAGACTGGATGTGTGAGAAGAGCCTCAGTTAAGGAGGGCCATGTTCGTGCGTGCAGGGATCGTGGTGCCTCCCAGGCCAGGGCCGGGCCCCATCTCTCCTCCTCCTCAGCTGCTCTTCCAGCTACTGGCCACCCTGCCTGGCTGGAGGTCCAAGAGGAGAGGTATCTGAGGAGATCCTGCACTCCACACCGGGTCTCCTGCCCAGCATTTTGGAAGAACCAATTCTTAAGTCTGGTACTGAGGCCGCACTGCCATGATGATAACTGGTGTCACCAGGACACCAGGGAAGGAGCTGCCCTTGGTGTTTACTGAGCGCCCGGTATATGCACTGAGCTGTCCATCATCTGCAGAGACCAGTGTTTTCTTGATGGTTTTACAGAGAGATGCTTAAACCCAGTGAACTAAGAATGGGACAGGCTGTCAGATTTTTCTCAAAGGAGGTATTGACTTGTTAGCGGGTACAATTAGGCCGAGGAACCAGGGGCTGATGCAGTGTGCTCCCGAAGAGGGGCTTCTATGGACTCCAGTTACCAGAGCCTGCCCCAGGATTTTCCTTCACACCTGCTCTTTATGCCAGGGATCAAGCAGGGTTATAAATACAACAGCGGGCAGGATGAGCCAGTGGTGGCCCTGTGGGTCTTCACAGCCCAAATTTCCTTCCATGGTTAGTGTAGGTTAAACCTGGCAAAAAGCTGCTTTCATTTGGAAGTCTCAGGATGCCAGCAAAGTGATGAGAGTGGTAGGGATAGAGGTGAGATGGGGGTGGTGCTGGTGATAGTGATGGTCATGGTGTTGGTGTTGGTGTTGGTAGTGGTGGTATTGGTGATGGTGATAGTGGAGGTCGTGATGATGGTTGTGGTGGAGGTGATGGTAATGTTGATGGTGGAAGTCATGATAGTGAGTGGTGGTTGTGGTGGTGGTGGTGGTGATGGTGAAGACGGTGGTGGTGGACGTGATAGGGATATTGATGGTGGAGCTCATAATGGTGAAGGTGGTGATGGTGGTGGAGGCAGTTGTGGTGGTGATGGTGCTGGTGGAGGCAACGGTGATGGTGGTGGTGATGGTGAAGACGGTGGTGGGAATGGTGGTGGTGGAGGCAATGGTGGTGGTGATGGTGGTGGTGGAGGCCATGGTATTAGTGAAGGTGATGGTGAAGGTGGTGGTGGAGGTCATGATGGTGAAGGTGGGGATGGTGGTGGTAGAGGCAGTGGTTGTGATGGTGGTGATGGAGGCGGTGGTGTTAGTGGAGGTGATGGTGATGGTGGTGGTGGAAGTCATGATGGTGAAGGTGGGGATGGTGGTGGTGGAGGCAGTGGTAGTAGTGGAGGTGATGGTGCTGGTGGTAGTGGTGAGGCAGTGGCGGGGAAGGTGGAGGTAATGGTAGTGGTAGAGGTGACGGTGATGTTGATGGTCGTGATGCAGCCATCTTCTGTGAGCATTTGCTTGGTGCCAGCCACTGATCTGTGAACTTCATGTGCATTAATTCCTTCTAGCTCCCAACACTCCTGTGTGGTGGGAGCTCTGAGTCTCAGTGGGTACAGAGGAGAAACTGAGATACAAATATATGTCCCTTGCTCCAGGCTCATTACCACTGCAACACACACTTTCTCTCCATCACCCAGATGGAGTCCACAGCCTTGCCTGGAATCCACAAGCTTGCCCAACCTTCTTCTTCTTCCTAAGTTCATGCCCTCATGGCCCGAGGAGCTGGCCTCCTGTCTCCAACCAGCATTCACCTCCGGCCCTGTGCTGTTGCTGCTCATCTGAACTGCCTCTACCTCCTGCTGCTTTTCCCCTCCTTTCACTCTGGCTCTGCCCCCAGCCCTCCCGTCCTGCCGGGCACTGGCTCCTGCTTGTGGCTGCAGCCCAGAGCAGTCCCTTCCCTTTAGCCTCCACTTGCCTGTCTGTGGCTGTCTCTTGGTCAGGCATTTTTTCAGAACGGGCAGCGTGGGGCAGCCCCCTTGGCCCCTCAGCCTGGGCTAGGCACTCTCCTCCATCCAGTGCTGGGCCCTTTAAACAGGTCAGGCAGCGTCCGCTCAGCAGAAGCGTGTGATGACTTCCCCAGCCGGCTGACCTCAGGGAGGGTGCACATGGGTGCCCCCAGTCAGCTCTCCTGACGTCCCTGCCGGGGTCAGGTGTCCCAGGGTCTCCAGCCTTAGGGTCTAACACATTCATCTCTCCAAAAGTAAGGATTCCTTGCCAGGGAAAGGGCTAACAAGCTGCCTGTTTTCTTGGCCAGCAGGCATCCTCCCCATGAGCCCAGGGCTATGGGTGACCAGCAAGCCATTAGCATATGCGTGTCCATCTGTCCTGCCTGGCTGGTGGGCTGCCAGGATAGCCGTTCCTTTTGCTGCCCAAGGAAGTACTCAGGACCCAGTTACTGTCACCTCTCCCAAGGCGTGCAGGTGGCGTAGGAAGTGCATGTCCGTTCTTTCTGTAGGACACACCTCAGGACCCCAGGGGACATTGTCAAGAGGCAGAACCAGGGTGCTCCTGCTGTGTACCAGGGCCGACAGCATTGTGTCGGGGAGCCCGCCCCCACATGCAAGGACACACCACACACAGGGAGGCGTGGAGCACATGTGGCCTGTCCCACCTGCTAACAGGCCGGCCATCGGGGCCCTCCTCTGGCTCATAGGCAGGGCATCTGGAGGAAGCCGTCCCTGCCAAGAGCAGGTTGAGTGTATGGGCACTGTCTGTCAGCCTCATACTCTTGTTATCATCAGACAAGAACCCTGAGAGTTAAGGGAGGCAAAGGCCAGCAAGGTCAGGACTTGGGGCAGAGATCGGGGCTGGGACAGGAGCTTGTTCAGGACAGTGGGCAGGACTCCCACAGGTGGAGAGGACAGGGATGGCCATGCACCTGGGAGCCCTGGGCCAGGCTGAGCGAGCGAGCACCAGGGCCCGGAGTGAGGGGCTGATGGCAGGGGCATGCAGGCAGCTGCACATACCAGGCTCTGTGTATGAAAGGGAAACTGGACATGTGTGAGTAGGCCCAGGCCTGGCAAATGGCTCAGAGAGACACCTGTGAACAGCTGTGTTTGGTGGCTGCCCTGGGCAGGGGTGAGGCTGAGAGCCCACTGAACCTCCTGAGTCAGAGGTGATGAGAGCCACCCCCAGGTGCAGGGAAGACACAGGGAATTTAGGAAGAGAGCAGGACGCCAGGCAGGGTGCACTTAATCGTCACTTGGAAACCAGTGTCCAGTAGTGGCTGCCCGGGAGCCTCTTGGGTTGGCACTGGGCTCGTGTGAGGAGGAGGCGTGGCAAAGGGAAGGGCTCTGTGACAGAAGGCAGTTGAGACTGGGCCGCTTCTGGGCGCTGCCTCCTCTGCTGAGGCCTCAGATGGGTCCCTGCCTTGCTCAGGGCTGTGTGCTCCATGCTAAGCCTTGTCCTCCTGGGGGCTCAGGCACAACCAGGTGACTCTCAAGCCAGGGCCACATGCGTGCACCATGGGCCCCTCCCACATCCAAAAGCAAAATTATATTCTGCAACTGTGTTGGTATAAGACAAACACAATCCAGGCCACTTTATTATTATTTATTTCTTATTATATTTATTTCATCCTTTTGATTTTAAAATGAATTAAAACAAAAACCTTTTTTGCGCACCCAGGCGCATGCAGCAGTGGTGCCGGTCAGGAGCAGAGGTTCCTCCTCTGCAGGCTCCTGGCCCCCTGGGACCCTGGCACCGAGGGCTGGCCCTAGCGGCCCAGCCCTTGTGAGCCCTCACACCTGCCTAGAGATGGCGCGCTCCCTAGCCAGTCAGGGCGCTCTCGTGCCTGGATGCTGTGGTCTCATGAGTGGACAGCAGCTGAAGTGGGAACTGCAGCAGATACTGGCCGTGCCCAGGTGTGTACCTGCCCCAGGCAGGTGACCAGGGCAGCAGGGTGATGCCAGATGGGGCCAAAAATTTCATGCTTCTGTTTGACCTTGGTTCTAGCTGAAGATTTAGCTGTGTACACATCTTTAAAACTGGGATCCCCCTATAAAAACCAGATGCACAGGCAGCCGAAGAAAGAATGGATGAATTGGGCTACATCAAAATGTAAAACTTCTGTGAACCAAGGCCACAATCAGAAGAGTGAAAACACAGCCCATGGAATGGGAGAAAAACTTGTAATTCATAGATCTGATCAGTGTTAATCCAGAATCTGTAGAGAACTCCTCACACTCAACAACAGCAACAAAAAAACCTGATTCCAAAATGAGCACAGGGGGCCAGGTGCGGTGGCTCACTCCTGTAATCCTAGCACTTGGGGAGGCTCACGCAGGCAGATCACTTGAGGTCAGGAGTTCGAAAGCAGCCTAGCCAACATGGTGAAACCTTGTCTCTACTAAAAATACAAAAAAATTAGCCAGGCGTGGTGGCAGGTGGCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACTCAGGAGACAGAGGTTGCAGTTAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATACAAAAAAAAAAAAAAACCCAACAACAACAACAAAAAAAATGAGCACAGGGCCTGGATGGACATTTCTCCGAATAAGATTTACAGATGGCCCCAAGAAGCACATGAAAAGATTCTCAGCATTGCCACTCATTAGAGAAATACAAATCAAAATCACCATGTGATACCATCTCACACCCATTTGGATGTCTACTATCAAAAAAAAAAAAAAAAAAAAAGAACCAGTGTTGGTAAGGATGTGAAGAAACTGAACCCTTGCGCACTGCTGGAAGGTAAATAGTGTAGCTGCTGTGGAGAACAGCAGGAAGGCTCCTCAAAGGTTAAACCTAGAGCTGACTTCGGCTCCAGCACCTCCACTCTGGATACATACAGGAAAGGAAGCAGGAAGCAGTCAGGATATATTTGTATGTCCCCATTTTCAGCAGCATTATTCATAGTAACCACAAAGAGGAAGTTACCCAAGTGTCCATTGACCAATGAATGGATAAGCAAAATATAATACAGACATACAATGGAATATTACTTGGCTTTAAAAAGGAAAAAAAATTTGCCACATCCTATGCCATGGTTGAACCTCGAGGGCATTATGTCACAGAAGGACAAGCACTGTATGATTCCACTTACATGAGGTCCCTGCAGTCGTCAAATTCGTGGAGACAGTAGAATGGAGGATTCCAGGAACTGGGAGAGGAGAGGAGGGGGAGTAATTGTCTCATGGGTACAGAATTTCAGTTTTACAGGATAAAAAGAGTGCTGTGGAAGGATGGTTTGCATGGCAGTGTGAATGCACTTAATGCCACTGAATTGTACACTTAAAAATTTTAAGATGATAAAGTTCATGTGTATTTTACCACAATTTAAAATAACTTTTTAAAACTAGAATCTCTCTTTATATACACCTCCAAATTTGTTATTTACAGTAGAGCCTCCCTTGATCCGTGTTTTTTCCCTAAATGCAAAGTTAGATTATAGTCCCAGGCAAAAGCAGCCTCCAGCTGGGACAGAGCCGAGGACCCAGGTTTGTGCAGCATGCTGCAGGTGGTCCTACCCGAGTGAGTCTGGCTGGCAGCTCCGGTGCCCAGGGCTCCTCAGGCACTGATAGATCATTTCCTGAGCTGAAAAGGAGTGGTTTTGTCCTCAGCCTCAGGCTTGTTTGCTCAGCACAGTGGCTGGCCCCACAAGGTTGCTGGTGCACTAGTGGGCACTGCACGTGTGCACAGGGCGCATCCACACAGCTCTATCCTGCCACTGACAGCCTGCCCGTGGCTCCAGTGCCCGTGAGACCATGTCACAGTATCTCCCCGTCCTCTTACTCCCTTCCCCTTCCCAAATTCTGACCATTTCCCAAATGTGCCCAGCCCTTTCACACTCCTGTTTATGAAACCATTGTACTGGCTCGTTGATTCATTGATTCATTCATTGGTTCATAAATTTATTCATTCAGCTCACAGAAAGTGAGTTGGCAGATGTGGCAGGAAGGTAGGCACCCTGTAAGAGTGAGGAGGAAGTGAGTTGGAGGGCAGAGGGGGCCCTGGGAGCCCTGATGAGGAGCTATGTTTTATTCTGCAAGCAGCGGACAGTTAACACAGGGCTCCACAGAGGGTGCCATGATTCAGTGGACCCTGGCTCCTCTGTGCGAGATTGCCTGTCCTGCCCAGCATGTGGTCCAGGGTTGGACAGGGGTGGCAGAGGGGACTTGGGAGGTGGGGTGAGGGGTGAAAGAGAAAGGGATCTGGGGACTGAGGTGTGTGACCTGAGCAGTGAGGTGGGGCCATACCGTGATGAGATGGGGAAGAGTTGGGGACAATTTGGGGTGAGGAGGGGCCAAACTGAGGCAAAGGAGTAGAGAGAGCAAGGCATGGAGATGCCCAGGCTGCTGATCAGCATGCTGCACACCAGCATAGAGACAGGATTAACAGCCCAGGGCCTGGATATGGCTGGTGAGTGAGCCACTGCCACCATCTGGAGGACAGGGTGCAGAGGAGGAAACCAGCCGAGGGGGTGAGCAGCCTCGGTAGCATCCCAGCGACGCTGGACAGCACCAAAGACAGAGGAGGTCCTGGGAGCAGCTGGGAGAAAGTGGGTTACCCAGGAGGGGCCGGCCTGAGCATGGGCCCTCAGCAGCAGCAGTGAGGCTGAAAGACGGGAGCCAGACCTTATGTAGAGTGGAGGAAAATAGCTGTCCACATGGAATTCTCCACCCAGCAAAAATGGGCCTTCCATGAATGACGTCAAAAAATGAGGCAAGAAGAAGGCCAGGCGCAGGCTCCTGCTGGTGGGGGTGGGACACAGTGGCAGGTGGGGAGGCGGGAGGAGCAGCAGTGTGGCCAAGCATCCAGTTCAGCAGGGCCACGGGCTCCAGGGTGTTTGTTCAGCATAAATGTTCTGTGAAATGTATTCGTTGTACATGTCAAATATTTGACTATAGTAAGAGAAAACGTGAGTGGGAAGTGGGAGGGAAGCGGTGGGGGGGTGGGGGTGGGGTAACAGGTCACATCCTGAGAGGATAACAGTGCTCAGCATGGGGCTGGAGGGACCCCCATAGGGACAGCTGGCCTGGGGAGGCGGGGACCGCCTCTTTCCACCCCCAGCCCCCAGGGAGGAGCCCTGGGGCCTGTTTCCCATTCCCAGGAAGATGATTGCATTAGGAAATCGTCTCTTAAGGAGATTCTGCTGGGCCATAATAAAGCTGTCATCTGCATCGTCTGCCACCCATCAAGGGCAGGCGTGGGGCTGGTGTCGCATGAGGGGTTCTGCAGGAAGGGCCTGCTCTACACACATGCCCTACGCTGCTTCTAATTCATGCAGTTTTTGGATCATATCGTTGTTATTGTTTTCTTTTTTGGAAGTCCCAAATTTCGGCCCTTGTGCTGCCATCCTAGGGAAGTTTTTCATGGTCTGGAGCTCCATTTGTGTTTCTGTGGCAGGGTCACCATGCCATGGCAAGGGTGACCTCACAGTGCCCCATCAGAGCTGCCGGGTGGTCGGCAGTGGGGGAGTGAGAGACCAAGGGCCACAGCCAGGAGCCAGTGGAGAGCTGGTGAGCCCCTGCCTCCACAGACAGGGCCAGGCCACGCTTAGTATGTGTGCACCGAGGGTGCAGGAAAATGTGTGTGCTTGTGTGTGAAAGCGGGTATATACCAGTATGAGCAAATACATGTGCTTGTTAGAGCCCTATTGGCAGTGTGAGAATGTGTGAGCATATGGGAGAACAAGTGTATAACAGTGTGTGCCCCCGTGGTGTGTAATGGTATGCGTCTGAGAGAATGAGTGTGTGTGAGAGAAGGAATGCATGTGTGCAATGTGTCCGCCTGAGTCTGACCAGGAGACAGCCCCACGTGGTCCCTGAGACAGGAGCAGTAACATCAGAGGCACTAAGCTGTGATGAAAGAGGGATGAATGGGGGTGGGGAGAGCTCTGTGGGGCACCCTCAGCTGCAGGTGGGCACCAGGGAAGGAACCCCTTCCCAGCTGGGGTCAGAGCCTGAGGGAGGAGCTGGATGCTAGGCTGGGGCTGCTGTGCAGGCTCAGGTCTGGCAGGAACTATCCTTAGGGCACGGGAGCTGAGGCTGGGGGCTGCAGGAAGCTGATGGCTAGGCTCAGGTATGGGCTGCATCAGTGCCGAGGGATTGCATGCTTTGGGTATGTGCTAGGGTGGAGCACATAGCACACCCTGTCTCGTGGACTGCCCGGGCAGCAGGACCTAGAAAAGGCAGGTGTAACAACCGGAGACAGGAGCAACCCCTGGCCTGTCCCAGCATCTCTCCAAAGCCCTCCACCGATGAAGCTTGGCCTTGTGCTGCCTGCAAAGTAACCTGCTCCAGGCCCGCCTGGGCATGAGAACATGCACACCTGGACGGAGTGTGTGGATTGACAAGGTGTGTGCACGCGCACATGTGGGACGAGGGGGCTCAGGACTGGTCCCCTCTGCATCCAAAGATGAATAATTTAAACAGCCCAGCCACGTGTGGAACATTGGAAACAGTCTAGCACTTCACTCTGTCAAACACTAGGGCAGACTCTTTCCTGCTGAGCTGGGCAGGGTGGGAGCAGATGGGGTCTTAGGTGGGCATGCCTCCATCTCTTTTTCTGTCTCCTGCATGCCCTGTGCGTGCATACATATACACACACTCATGACACACACTACATAGGCCTTGAAGGTTTCTGAGGTCTCTCTGAATGTGAGCAGCAACTTGGGTCTTTGGCAAGTGTGCTGTGAGCAAGCAGGACCTTCCCCCACCCCATCCTGCATGGTGCCTGGGCACAGCCAGCCTGAGGAACCAGAACCACGGTGGCGGGGGTCATTGAGGGTTGATGTGGGAATCCTCTTAGTTTCTCAGACAAGCGACACTGCCATTTGCACCGTCGGTGGGTGTGGTGTGTGCCAGGCCACCGCTGTGCTGCAGAAGTACAGGGTGGGCCCAGCCCTGGCAACCAAAGCTGTCCAGGCAGACACCTGTGTGCTAGGTTTGAGGGAGGATTCTGTCACCACGTGGCATTTGGGCTTTGAAGGCATGGGGTGGGAAAAGCTTTGTAAGTCCTGCTGGTGACCTTCCCATGGTGCCAGGAGTGGGAGTGTCTGTCACCAGACGTGGGTCTCGACCCACGGGCCTGGCCTTGGTCCACAGGCCAGGCGGCCCTTCTAGGCAGAAAGGCGGCAGCAGGATGGGAAGCCAACCAGCAGGGCACTGGGCCTCCTGGCAGGCTCAGCACCTGCTGGCGCCTGGCTTCCACCATCACTTTCTTAGCTGTTATCCTAACCCCCGAGACACAAAGCCTCACAGCATGTCCAGCTATTTCACTTGGTCAGGCTTCTCGCCACCCAGCCTTGCTGTTCTTATATGTGAAATGGGCAGTGAAGGGATCTGCACCCAGTGGCTGAGTCTGCAGTGAGAGCCTCATGATGATACACCCCTGTGCAGAGGTGCACGCCTGGCTGCACCTGCACTGGCCGTTCCTCCTCTCCTTAGCATGCCTCCCCCACTTCGAAGCTGGGGAAACTGAGGCCCAGAGGAGGCCAGTGTTCTGCAGAGTCTGCACAGTCCGGTGGTTCCTGATGCCAGCAGCTGTTCCCCAGCTCTCCCCTGTGGCTGACCCACCACGATTGGCTGCATCATTTGTGGGCCCCTTGATCTAGAATTATGAAGAATTTCAAGACTGTAGCAAAGAGCATTAAACCAAGCGTGAGACCTCTGAGCAGGGCCCACTGGGACTGCCCAGGCTGCAGTCCGCTGAGGCAGGTCCTGCACCCACCTCCTTCATTCTCCCACCTTGGACCATGTGTTTTTCCATCTAGAAGTGTCTGTGACAAGCGGGAACCTTAAGACAGCTGTGCCCAGCTGCAGAGACCACCTGGGAGGCATTTTAAGTGCATTTAAGTCTGTTTCTGCTCGCAATCATTGCCTGACCCACAAATCCCTTTTGGCAGCAGGGAGACCAATTGGGATTGGGCCCCCCACGATCCTGTAGGGGTGGGCTCTGCCAGATGGGAGCAGGAAGGCCCGTTCTCCCCTGCACATGTGGGCTTTGTGGTGGGGGCTTTGGGAAGCCCAGGCCTGTCCTACCTCTAGTCCCTGGACCACTAAAGGTGCTTGCACATCATGGAGGCCCCAGAGGAGCACCTGTGGGATTCCCAGACTGGATCTGCTCCTGCGACAGATGGGGTGCCAGGGCCCTACCCACTCTTCTGCAGCCTGGGCATCACCAGAGCCACCCCACGGCCACCCAAGGGCAAATGGTTCTTATTGGGAAGACCAGGGCCAGAGGTGTGTGTCCCAGAGAAAACTAGACCCAGCTGAGCTGCATTGCCTCTCCCCACCTGAGCTCAGCCAACCCCTAGCATCCTCTCTGGGGTAAGAACATGGACCCCACTGCCTGCATGGATAGCCCAGACATAGGATGCCACATGGGATTGGGAGGGGGCTCATCGGGGCCAGGGCATCTGGACCCTCCTCGCCCTGTGAGGCCACTATGAGTTACAATCTCTCACCCTCTGTCGCCAGAAATGCAGCACCCCCTCCCACCCCGAGGGCACTGTCATGGGAGCAGTGTTCCTGATGTACAGTGAGCACTTCAAGAGAAGCTTTCTCCTGTTCTATTTTCCCACTGTGGGACTCCAGACGTCTCACCTGTTCTCTTCCAGGCTCCCCTTGGCACTTGATTGTTTCCCCCAGGTGTGTCCTGGAGGAGCCCAGCGGCCCTGGGGGCGTTCTCAACTGCTGCTGCAGGCCCCGCCCTCCAGACCCCTCAGCGACCTCAAGCAGCAACCGTCTGGGTGGGAGCAAACTGATCAAAAAGAGAGATCGATTACATACAAGTGCAGTATTCCTAATGTGTCCTTTGGATGTTGGTATTGTTTGGGCATTCTAGAGTCTATTTGCAGGTTCTTAATGGATTTTAAGCATTTTTTGCCTATTTATCCATCTTTTTAAAAATTCATACGATTTTTTATTGTGGAAAAATATACACAAAAATGATTTACAATGTAACTATTTTTAAGTATACATTTCAGGGACATTAAGTACATTCACATTGTTGTACAGCCATCACCACCTCCGTCCCTGAACTTTTCATCTTCCCAAACTTAAACTCTGTCCCTATCAAACACTAACTCCCCATCCTGTCTCCCCCAAGCCCTAGCAATCACCATCCTATGTTGTGTCTGTGAATTTGACTACTCTAGGGATCTCACATAAGTGGAATCGTGCAGTGTTCATCCTTTTGCAATGGGCTTATTTCACTTAGCATAATGTGCTCAAGGGTTATCAGTGTTATAGCCTGTGTCAGGATTTTCCTCCTTTTTTTTTTTTTTTTTTTGAGACAGGTCTTGTTCTGTTGTCCAGGCTGGAGTGCAATGGCACAATCTCGGCTCACTACAACCTCCGCCTCGTGGGTTCAAGCCATTCTCCTGGCTTAGCCTCTCAAGTAGCTGAGATTATAGGCGCCCGCCTTCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCTAGGCTGATCTTAAACTCCCGACCTTAAGTGATCTGCCCACCTAGGCCTCCGAAAGTATTAGGATTACAGGCGTGAGCCACTGCGCCCGGCCAGATTTCCCTCCTTTCTAAGACTGAATATTCCATTGTATGTATAGACCATGTTTTGTTCATCCATTCATCCATTGATGGCCACTGAGGTTGCTTCCACCTTTTGTCTATCGTGAATAGTGCTGTTGTGAACATGGGTGTGTAAATATCTATTTGAGACTTGGCTTTCAATTCTTTTGCGTATGTACCCAGAAGTGGGATTGGTAGATCATATGGTAATTCAATTTTTAAGTTTTTGGGAACTACCTTCTTGTTTTTCATGATAACTGTATATTATTTTCCATTTTCACCGACAATGTACATGAGTTCCAAAAACTATTTTAAAAGCTTTCCACTGTGGGAAATGTTGGCCACACACAGTCAGCAGCATAGTGCACCGTGCCCCTGCTTGGGCTCACTCAGCCACAGCCGAGGCTAGCATCCTGCCTTCTTCAAGGAAGCTACGCCTCTGTCCACAGCGCCTTCAGTGATTCATTTTTCAGTTATTTAGGTAAAAATTACATAGATAGGCCGGGCACGGTGGCTCATACCTGTAATCCCAGCACTTTGGGAGGCAGAGGCGGGCGGATCGCCGGAGGTTGAGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAGAAAATACAAAATTAGCTGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTGGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGTGGAAGTTGTGGTGAGCCAAGATTGCACCATTGCATTCCAGCCTAGGCAACAAGAGCAAAACTCCATCTCAAAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAAAATTACATAGATAAGATGCACGGACCTTAGCTGCACAATACTGACAAACGAATATGCCCACGTGATCTGCACCCTTCTCAGGATATGGGACCTTCACATTCCCCAGAAAGTGCCCTGTGGCCCTTCCCAATCTGTCCACCTCCCCCACACCCCCGCCTGCCACAGGCAGCCAGTCTGATCCATTGCCTAACATCCGTCCAGAATCATGCCATGTGCGCTCTTCTCTGCCTGGCTTCCTCACCTTGGCATGGTTTGTGTGTGTGACCCATCCAGGTGTTTGCGTGTATCCATAGTTCATCCTTTTCCATTGCTGGGCAGGATTCTGTGGCATGGCTGGACCACGGTGTGCCTGTCCATCCACCTGCTGAAGGGCCTCTAGGCTCTTGACTTCTGTGAATCATCCTTCCATTTCCAACTATGGCATTTGATAGACGTATGTTTTCACTTTTCTTGGATGAATGGAGTGGAATTGCAGGGTCATATGGTAGGCGTATGTTTAGATAAAGATTTATGACTTTCCTGTAAAGTGCTTTCTTCATTTTTTGGCAACTGTTGCCTGCCCCACATGGGTGGCAGTGTCTCCTGCCCTTGAACACTCTGGCTCTGGGTGACCTGTTGAGAAGTCTGTATGGTTCAGGTGCCCTTCCGGCTTGGATGATTGAGAATAGGCTTGTCACTGAGGATACTGCTTCCCCTGTTTCCTTTTCTTTTTCTGTTTTAAAGCAGTTCTTTTCTAGCCCGTGTGTAACTATACAAATAATTGAGTGTTCATGTTCTCAGGAACAGAGATGAAAAACTCCTGCTAAGATCGGAATTTTAAATTAATGATTTTTTTTTTTTTTGTCCTTGAAGAAGCCTTATTCTCACCATCCCTCACTCACTTCCCTACTTCCCACAGTGGCATTGGGCCTCTACTTCTCGAGGGATGCTTACTGGGAGAAGCTGTATGTGGACCAGGCAGCCGGCACGCCCTTGCTGTACGTCCATGCCCTGCGGGACGCCCCTGAGGAGGTGCCCAGCTTCCGCCTGGGCCAGCATCTCTACGGCACGTACCGCACACGGCTGCATGAGAACAACTGGATCTGCATCCAGGAGGACACCGGCCTCCTCTACCTTAACCGGAGCCTGGACCATAGCTCCTGGGAGAAGCTCAGTGTCCGCAGTAAGGGAGCCGCCCCAACACCCACCCCGTGCCCCACCCCACCCCTTCCTCAAGCCGCCCTTATCACAGCCGCTGACACTGAAGCTTGGCATGGCTTCCCCCCCACCGCTGGTGTGGAAGGCGTCAGGGGTTAAGTGAGGCTGGCCTGCCTCTGTGTCCAGCCTGGAGAGAAGCCAGGACAAGCTTCAGGGCTGCGTGAGGCTGTAGGAGTTTGGAGACACACGGGAATCATCCGGGTACACTCTTCTGCCAGACCCGAATCCCTCTTCCAGTGGGGCTAAAAAGGATTAGGAGGTTTCGAGAGAGGGAGTAAGTGGGGCTGGAAAAATCCCAAGGTTTTGATTTAGCAAATGACCTGCAACTCTCTGGAGAAGCGGCAGTTCCCAAGGAAAGCCTGACTTCTTATCAGCAGCTGGCTGCCCTTGTACCTGGCAGGGACTTGGGCCTGTCCCAGGTGTCCAGGGAGGAAAGAGGAGCAGTCAGAGCCAGAGTCACGGCCACATGTGACATTGGTAATGGGAGGGGTGGGGGGGAAGCAGAGCCCCTGTGACAGGAAACGGTGATGCTGCACCTGGTAGCTCCCATCCCTAGCACCCCTCCAGGGCCACAGCTTGCACAGCCCTCACAACCACCCTGAGCCCTGTCTGCTGGTGAGAGGCAAGCCTCAGGCTATGAATGCAGAGCAGGCATCCCTGCCCTACCCAGGCCTATCTGCCAGGGACAGCCAGGGTGCAGGGGAGGGAGGAGACTTGGGTGGGCAACTCCCTCCGGCGCAGCCCAGGCAGTTCCTGGAGGAGGCAGCATCTGAGGTTGGTCGTGGTTCTACGCACTTAGTTGCTGCCCTCTTCATCCTGAGCCTCCAGGGTGGAGCTTGAGGAATGGGAGTCCCTGGGTGGGGGCCAGTGTGGAATTTGCCCTGGGCCTGCATTTCGTAGGAGGCCTAAGCCCTCCAAGGTGGGGAGAGGCTTCATGCACAGCCAGTTCCTGTGGAGGAAGAAACCACAGGGTAATTTAACAGGGAGAGTTTGTGTAAAGAATTAATTACAACAGGGGATTGGAGCAATGAGGGACAGGCTAGCAAAAAGCAAAGAGAATGCCAGAGAATATGGGAAGAGCAGCTCTGAGGAGCAGCCGCCCACCTAGGGCTGAGATGGAGGCTGGGAAAGCCCTCGCAGCCCAGCTGAAATGGCTATGGCGCTTCGGTGATGGAACTTGCCGGAAATGCCCCCTCTAGGCATTGGGGAAGTATGTCTGCGGCCACTCCAAACCTCCTGAGGAGGGTGTGGCAGGGGGGGTGCTGGTCACCCCTTACTGGAGAAGTTGCCACCATCAGAGTTGGGGAGCCTTAGACCCAGTGCTCAACACACCTCCCTGAGGAAGGGGCCTCTAAGCCAAGAACTGAATGATGAGAGCTAGGCCTGTGGGGCATTGGTGCTGGGCAGCAGGGCTGTGCAGCAGAGGTAAGGAGGTGGCAGGCAGAGCTGGAACACCAGTCTGAGCCTTGTGGACCTTGGTGGGGACCAGGGTTTACACCAGCCCTGGAGCTCCTGCCTCCTCCCCATTCCCGACTGCCTGGCAGATGTGGCCGATGCCCCCACAGACCTGACTTCTCTCTGCAGACCGCGGCTTTCCCCTGCTCACCGTCTACCTCAAGGTCTTCCTGTCACCCACATCCCTTCGTGAGGGCGAGTGCCAGTGGCCAGGCTGTGCCCGCGTATACTTCTCCTTCTTCAACACCTCCTTTCCAGCCTGCAGCTCCCTCAAGCCCCGGGAGCTCTGCTTCCCAGAGACAAGGCCCTCCTTCCGCATTCGGGAGAACCGACCCCCAGGCACCTTCCACCAGTTCCGCCTGCTGCCTGTGCAGTTCTTGTGCCCCAACATCAGCGTGGCCTACAGGCTCCTGGAGGGTGAGTGCCGACCTTGTGGGGCCGCCCCACAGTGCCTGCTACTGCTGGTCTTGCTCTGCGAGCCCTTGACACAAGCCATCTGGTTTATTCTTCACCTTCATGCCATCAGTTCATTCAATATTCCAGAAGTACCTCTTGCATGCCTGCCAGGGGCCAGGTACTGTTCTAGGAGCTAAGGATATAACAATGAACACAACGGGTTGGAATCTTGCCTGCCTGCAGCTTTCATTCTTGTGGGGCAGACAGAGCGTCTGAGCATGCCAAGGAAATCAGGTGGCTTCTGGAAGGAGCTAGCTGGGGAGGAAACTGGGAAGAGGGAAACGCTGAAGAGGAGGGGAACAGACGAGGAGACCTCCATTCCTCTATCGTAAATTGGGTGGTCAGGGTGGGGGCTAGCAGAGCAAAGGTGGGAGGGTGCCGGGTAGGCAGGCCTAGCCCCTTGGAGGGCACCACAGTGTGACCCTCGTGTGCCTGGAGTGCACTGAGCGACAGGGAAGAGCTGAGGCTGATGGGGCAGAATAGTTCCTGGGGCAGGGGGCAGGTCTGGGAGTGGCTTGCAGGGCTTTCTCCGGAGGAACATGGGGAGCTATGGAAGACTTTGGAGGGAGGGAGTGCTGGCAGGACCTGACTTAGTTTTAAAAGGATTAGTCAGACTACTGTGTTAGGAATGGTTTGGGGTGGGAAGGTTCAGGGGCGAAGCTGGGAGACAATCAGAAGGCTACAGGAGAAACCTCTGAACAGGAGGATGTGGGGTGTGATGCCGGGATACGGGTGGAAGCCGAGGCATGGCGAGAAGCAGGCAGCTGCAGCCAGTCAGAGGGTGGGATGAGCTGGATCCCAGTGGAGAGGGGAGAAGGCAGCTGACTAGGTGCAGGGAGGCCCCATTTGACCATCAGAAAGTCAGGAAGTGGGGCTCAACCAGGTCACAGAGGCTGCACCGCTGGCAAGTGTGTCCTAAATTCACACTAACTTTATCACACAAACATGGCAAGAATATTAAAATCTCAGTAAAGGAAGACAAGCCATCACTTATGCTTCCCCAGATTCCTTTCATTCTCTGGGGCAGGGTTGATGGAGCACTTGGTTTTTTGCATGCTGCCCTTTTTCACTAAAAATTATGTGATTAAATTTAGTTTAGTGGGGGGTTTTTTGTAATCACACTCAACAGAGGAAAGCATTATATGATAAGCATTTCCCACATACGTAATTCATGCGCAAGGCATGGTTCTGCCTGGGAGGCTTGTGGAGTTGCCCCCGCCTCCTTGGGGTGGGTTGTGGGGTCTTCAGCGGTGACCTTCCGCCTTCAGCATGCCCCCTTTTCTGGATTATTTCTGGAGGACAAATCCGAGGTCAGGCTCGTTGAAGACTGTGTTGTGGTTCCTGGCCCTGCTTCAGGGGCGATGTAGTCTAGCGCGAGCTGCCATGCAGGGCACGGAGCATTCGCTTTTGTCTCGACATCCGGCCTTCAGAGGATGACCAGCCTGGCGACGCACTGGACAAGGAGGTGTAGAGTGGGGATGCACACTAGGCGGTCGGAAATCATTATGCGTTAATGTCACATCATACCCCAGATGTCCACTGTGTTTGTTTTCAAGTGGTAGAATCGTGGCTTTCTCACGTTCTCTAAAATGAACACATATTGCTTCCATAATTGAAAAAAAAAAAAACCTAACAGTTTTTAAAAAGCAGCCAAGGTCACCAATATGGTGAAAGGCCGTCCCTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCCTGAACCCGGGAGTTGGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCAACACAGCGAGACTCCATCAAAAACAAAAAAAAAGCAGCCAAGGCCAGTAGCTGGCTCTCTAGGGCTGCAGTGCAGCTTGGGCTGAGGCAAAGCCACCCTTCCCCACACAAGGCCACTCCTGATCAAGGCCAGGTGGGCGGAGGGGTGTCCCAGTCCCTACTGGTTGATCAGGGTGCCTGGTCCTGGCTCTTCCCAACCAGCACGAGTGAGGACGCAGCTGCAGCAGGACGTAAGCACAGTCATCGCTGCAAACTGCAAACTCGTAAGCACAGTCATCGCTGCAAACTGCAAACTCGTGCTCCGAGCGCTGCCCTCCCCTGTGGAGCGGAGGAGGGGAGGCCTGGGGCCGCGGCGGTGTGCGCCCCGCTCTGACCGCAGAGCCCCCTTCCCGAGGAAAGCGGCTGGCCCGGTCCCGGCTGGTGATCACGCGGGGCCCCTGTCTGCTTGGTGCGCAGGTGAGGGTCTGCCCTTCCGCTGCGCCCCGGACAGCCTGGAGGTGAGCACGCGCTGGGCCCTGGACCGCGAGCAGCGGGAGAAGTACGAGCTGGTGGCCGTGTGCACCGTGCACGCCGGCGCGCGCGAGGAGGTGGTGATGGTGCCCTTCCCGGTGACCGTGTACGACGAGGACGACTCGGCGCCCACCTTCCCCGCGGGCGTCGACACCGCCAGCGCCGTGGTGGAGTTCAAGCGGAAGGAGGTGCTTGTCCGCGCGTGCTGTGGTCTACCCAGTGTCTGTCTCCGGCCACAGTTCGTTTCTCGGTCGGTTTAGTGTCCGTGTAGCCACCCAACCGTGTGGCCGACCATTCGCGCTTTCATTTGTCCTTCGCCTCCGTCTGCGCCGTCTGTCCTAGGGGGAGGGGAAGGGGGAGTCCTGCCAGCACCCAGCTGGGCCTTGCCTCGGGAGGCAAGGACCAGGACGAGGCCCGAGGGCTCGCGTCTGGGGCATACTTGTGCCGCTGCAGGCGGGCGCGGCGCGCTGCCCGGGCGGGGAGCATCTGCCGGGAGGGCACTCCCTCCCACCAGCAGTTAGCCCCCAACGGGAGGGCCCTTGAGTGACCACGAGCAGAGCCGGGGATTGGAGAAGGACGGGAAGGCGGATCACCTCCGGCGCCGCCCGCCCCGCCCTTCTCCGGCTCGCGCTGGTGGAGCGCGACCGCCACCTGCTGGGCCTCGGCCTTCCTGCAGCCGGCCCACCCAGCAGGGGCCGTGGGAGAGTGGGCGTGGGGACTGAGGTAGGTAGTACGTTGCCTTGTTCCGCTTCTCTGGGCACACCACGTGCAGGTTTGGCAGGGAAAGGGGGTCTGGTCGAAAGCACAATTTGTGAGTAAAGGCTATGTGGGCCTCCCTGGGGTGACAGCAGAGGCCTGGTGGGCAGAGCCATCCAGGTGCCCAGCGGCTTTCCTCACAACCCCCTCCAGCCTGGGGTAGGAGGATGCTTGGAACAGAGCGCTCTGATGTACACCTGGCCTCGGAGCTCGGCTCTGCCGGCTGTTCCTGTGTGACCTTGACCTGACCTTCACCCTGTGGGGCCCAGCTTCCTCAGGGGAGAGTGGAGGTGCTCATCCTGCTCTCTGGGGACCTGGATGGGACCTGCCAGCAGGGTGCCTGGGCATCGGCTGTAATTCTCCTTATAAGAGGTCTGCATTGTACCTGTTACACAGGCGAGGCTCAGTGGCTCAGGGAAGGTGACGGCCAGGCTGGCCAGTGACCCCGTGGGAACTTGAACCCAGGTCAGACTGTCCCCAGACCTGGCTCTGACAACACACATCTGGTCCACCTATGGGCTGTGTGGGACGTGCAGCATTCTAAGGTCTCTGGTTTTGGGGGGTCTGAGGGGCCCATCTCGCCTGCACTGACCAACGCCCTCTGCATCCTGCAGGACACCGTGGTGGCCACGCTGCGTGTCTTCGATGCAGACGTGGTACCTGCATCAGGGGAGCTGGTGAGGCGGTACACAAGCACGCTGCTCCCCGGGGACACCTGGGCCCAGCAGACCTTCCGGGTGGAACACTGGCCCAACGAGACCTCGGTCCAGGCCAACGGCAGCTTCGTGCGGGCGACCGTACATGACTATAGTAAGAGGGGCTGGTGGCACGGCCTGGCTAGGCCCCCAGGAAATGAGGTGCTCGCTCTTCATGGGCAAGCAGCACCCTACACACATGCACACCTGGCATGGCCCTCTGTGGCCCAAGCCACTTCCCCTCCACCCTCTGCCCAGCACTTCCTGTGTCTCTGCCAGGCCTGCCCTCCAGCCACCAGCAGGGCTTTCACCATGGGACCTCTCTCCCTGAGCTGATCCATGGCCGACCCTGGCAGGGCCCCACCACACCCCCCTGCTGACCTCACCAGGGCTCACCACCGACTGCAAACACACATGTCACCTGAGGCTTTCCTCCAGCCCCTGGCACTCCATCGTTGCCCCTAAGGCGTCCCAAGTGCTTACGGATTATTGCTCCAGCCTCAGCAGCTCTCTGCTAAACAGGCTGGTGTACAGAAGCAGCCCCGAGCCAGGTCAGGGCTTCTGAGCCCATTATCCTGCCTGACTGCTGACATGCCACCATGCTCACCTGCTTGCAGGGCACCTTTCAGCAGCGGCCTTGCTTCCTGCCTCCCTCCGCCACCTCCTGCAGATTTCTCCTGGGATCGCCTTCCAAATAAACCACCTGCATTTGGGGTCTGTGTCTGGTGGAACCCCAGGCCATGAGTCCTTCACCCCTTTCTGCCTGGCCTGGTCCTGTTCATTCCTCAGTCCTCCCCACCTCACCAAGCCTATGGAGGCCCCACTTGTCAGAGGGGAGACAGCCTCCTTGCCCTGGCACTGAACACCCTGTGTGCCAGAGTGCCCCTCCCATCATTGTTTCCACCACATGAGATCCACAGTGGCAGCACGCGGCAGGTACACCGATGGCATGACTTCCAGGGCTTGGCCTGCGGGGTCATTGGGTCTGCTGGAGGTTCCTGCAGTGGAGGGTAGTTCTGCCATGCTCTGGGGGAGCTGTCTGGAGGGCTCTAGTGTGTCCTTCCCAGGGCCTTGGTAATGTAGACCTTTAACCCCCCATGCCTCACACACACACACACACACACACACACACACACACACACACACCCTGTTACCCAAAAAACGAAACTCTGTAAAACATTTTAAAGAGGTTTATTCTGAGCCAGGATGAGTGACCACAGCCTGGAGAAAACACAAACCCAAGAAGCCTTGAGTAAGTGGTCCCCAGGTCCAAGGTGGTGGAGTTACAGTTTGCTTTTATACATTTTAGGGAGACAGGAGTTACAAGCAAGGACATAAATCAACACACAGAAGGTATACATTGGTTTGGCCCCAAAATGCAGGGTATCTTAAAACAGGGGCTTACAGGTTAGAGGTAGATGCAGAGATTCTTTAATTTACAGTTGGTTGAAAGAGTTAAGCTTTGCCTAAAGACTTCAGGTCAGTACAAAGGAATGTTAAGGAGGCCTGCTATGTGTCGCCTGATGCTATACAGGGTCAGGAGGGAAAGTAAACCACGTTATACCTGGGTAACTTAAAAAAAAAAGGTTTTTAACAAGATTTTATGGACCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGGAGACCGAGGCGGGTGGATTGTTTGAGTCCAGGAGTTCGAGACCAGCCTAGGCAACATGGTGAAACCCTGTCTCTACAAAAAAAAAAAAAATACAAAAAATTAGCCAGGCGTGGTGGCACATGCCTGGATTCCAGGAACCTGGGAGGCTGAGGTGGGAGGATGGCTGGAGCCTGGGAGGTCAAGGCTGCAATGAGATGCAACAGAGCAAGACTCTGTCTCAAAAAAGAAAACCAATGTTATGGTTTGTAGGGTGTTTCTTAACCCTTGCCTGGCATGGCCTTAGGTCCTGTTTATAATTTGGTATCTTACTGCCACAAAGAGTCCGATCTGTCAGTCTTATGATCTCTGTTTTAATGTTAATGCCGGTCAGTTGTGTCCAAACTCCAGCAGGAAGAGGGCCTAATAAGGCAAGTCCACCCTGCCTTCCTGTCATGGCCCAGAATTCTGTTTTTAAGGTTTTTCTGGTGTCCCTTGGCCAAGAGGGGATCTATTCAGTTGGTCCGGGGACTCAAGATTTTAGTTTCAGTTTACAACTCTATACACAAACACCCCATACACACAGGCACCAATACCCTATGCACAGACACCACACAAATGCATACTACACACTTACACATACCACACACACGCATACCATGCAAGCATATCATACACACAGACACCCCATACAATGCGTACACATGCACACACACACAGGCTGCCTCAAATTGAGAAGGGTTCCTTGGACTTTCAGTTCAGTAAATCCCAACGTTTGAACATTGGTGCTAACTTAGGACCAGCCCCAGGCCTGTTGCATGGCACTGTATGTGTGAAAGTGCGTGTTTGCACCAGTGTGAGTGCAGGGCTGTGTCTGGGAAGAGGTGTGCTACACATGAGGAAGCAGCCAGAGCAGCTTGGTGGTCATTGTTGTGCCCCTACCTGCAGGGCTGGTTCTCAACCGGAACCTCTCCATCTCGGAGAACCGCACCATGCAGCTGGCGGTGCTGGTCAATGACTCAGACTTCCAGGGCCCAGGAGCGGGCGTCCTCTTGCTCCACTTCAACGTGTCGGTGCTGCCGGTCAGCCTGCACCTGCCCAGTACCTACTCCCTCTCCGTGAGCAGGAGGGCTCGCCGATTTGCCCAGGTGAGCCCATACCTATTGCCTGTCTGGGGAAGATTGAAAGGCCAAGGGACATGGGGGCACAGGGAGGCAGGTGACACTGCCTCTTGGCCCAACCAGCACAGAGTAGACTGGGTGGAGTCCTGAGCCCAGGGCCAGGAGGTACAGCTGTGTGCACAGAAGAGGCCTGGGAGAGCTCACAGTGGGCAGGGCTGGGGGCTCCTTGGGCCTCTCTTTTTTTCCCCTTTCCATTCTTGGTATCTTTAAAATGTATTTTCAAAAATGCAAGAGCAATACTGGGTAAATCTGCATATGGTGACTCGGAAGAATCTTCCTGGTGGATTGGTGAGAGTGGCTTGCAGAGATGTTGGTCCCACGTGACTCCCTTTGTGCAAAAGCAGATCTTCCCTGACAGGGATCTGCAAGTGTGCAGAGATCACAGTGCTGTCCACAGTGGTGCCCTCAGGGGGAGGCAGGAAACGCTTCCACTTTTTACTTTTTGTAACTAGGTTTGCTAGAAAGCGTATATTTATATTTGTCTTTGGAAAATAATGATTAGAAATAGAAGGCATAAAAGTAATAAATATTCATTAAAGAAGATGAGGCATGAGGCATGAGGCGTGATCCCTTCTACCCATAGGCGCCAGTGTTGCACATCGTGGTGTTCTTTCTGGGATGTTTCTCGTAAGCACTTATTAAGTTGACTTGAAACTGCAGCACGCATGTTCTCGCATGCCGCTCTCCCTTGCAGAGCAGCCCGTGGCGCCTCCTCTTCAGGGGCCATCTGCCAGTTCTTTCGGGTGGTTCTGTGCCCGCATCAGCTCCTGGCAGCCACCCGTGTCCAGCCCACGAGGGAGCCCACCCTTGGACATATCTAAGCTCCCCGACCACCTCCTTGGCCTTTAATGGGAGTGGGATCAGAGACAGAGGGGCGACAAGACAGAGGGCCCCGGGGGGTCTCATGGGGGGCGGGGCAAGAGCAGGCATTGCTGAAGTTGGGTCACCTGCCCTCTGTCAGGAGCAACGGGGGCCTGAATCCCAGTCCAGCCTCAGCCTCACTGTGGTCTCACCTTTCTCCCCAGTTTGTAAAGCTGTGAATTAGGGACAGGAACCCTGAACAATTTTGAGAGTCACATGAGCATTTGGAAGTGGGCTTTGTAGGGGAAAGTGAGGAGGCCCAGGAGGCTGGTTTTTGCTGTGGTCACTTGTGGGCCTGGGAGAGCCCAGCCCTGCTCTGGCCCGCCCCCATCTCGCCATCTGTGGAACTTTTGGTTTCAAGCAGCTGCAAGAGTTGCCAAGAGGTTGAAAGAATTCAGCTGCCTGACTCCAGGTCCTGGCATCCCCAGGAGAGGCCCCTCTTTCCCAGGGGCTCTGGTCAAAGTCCCAGAGCCTGGCATCCCCAGGAGAAGAGGCTCCTCTTTCCCAGAGGCTCTGCTCAAAGTCCCAGGGAGGCCCCCTGGTCCTGCATGGGCTGGGGCAACCATGCTCCCGAGTCTTGTGGCTGGGGTTCAGTGCTCTGACCAGGGGACACCAGGGCAGGGTGGACCTCTAAACCCTGTGCACTGAGGGAGGAGTGAGGGGTCCCCAGAGCACTGCTGGGGCAGCTGGGAGCAGCCAGGGAGGAGCCTGGGAGACATTCCGGCGGCTTTGTTGTCTGAGTGAGGGAGGAAAGGGGAGTAAAGGGTTGAGTCAGGGCCTGCCTGGGGCTTTTCCTGCCACCAAACTGAACCTCGAGGCCCTGGGTTGCCTTGACCTCCAGCTCCCAGGAACAGGGGCAGCTGGTAACATGTGGCCTGAGTGGAACGGGGCAGGGCAGGGCTGGGGCAGGTGGGTGGGTATGAAGGCTCTGAGGGGTGGAGGACAGGGTGCTCGGGGGGGCTGCTGTCTCCAGGCCCAGTTGGGGGCTGTTCCAGGACTTAGGCTGTGTGGGAATCTCTACCCTCAGGCCATTACAGGCCGGTCCAGCTGCCTGGCTAAGGTGTTCCCCTGTGCCCCCCTAGATCGGGAAAGTCTGTGTGGAAAACTGCCAGGCATTCAGTGGCATCAACGTCCAGTACAAGCTGCATTCCTCTGGTGCCAACTGCAGCACGCTAGGGGTGGTCACCTCAGCCGAGGACACCTCGGGGATCCTGTTTGTGAATGACACCAAGGCCCTGCGGCGGCCCAAGTGTGCCGAACTTCACTACATGGTGGTGGCCACCGACCAGCAGACCTCTAGGCAGGCCCAGGCCCAGCTGCTTGTAACAGTGGAGGGGTCATGTGAGTGCCTGCTCCAGGGAGGGAGGGTCGGGGTCCTGGGGGCTTCTGGAGCCTGGGCCTCCTGCCCTTTGAGAAAAGCAGTACAGCTGCAAGGCTTAGCTGGGGAGTGGGGAAGGCATGGACCAGCTTCACCCTGAGTGACCCAGCAGTAAATGGTTGCTCCTTCCAGATAACATACAGGACCTTGGGTAAATTTGAATTTTGGGTAAACAACAAGCAGTTTTTTGGTATAGGTGTGTTCCATGCAACTTTTGCAGCTTCTCGAAAGACACACCTCTAGGTCCATCCATGCCCTCTTAGGAACATGCTGACACAGCTGCCATTCATGCCATTCATTGTGTATCTGAAATGTAGGTCCCACAGGGCGTCGTTGGCTGAATCTGGCTGCACTCACATCCTTCCTCCTGTACTTACCCCAGCCCAGGTGACCCCTGCTTTGTGACCATGATGTCCTGTACCCTGCCCTGCGCCCTGTGCTCCTGGCACTGTCTTTGCTGCCCTGGGTCTGTCACTCCGGTCCCCTTGGGCTCCATCCGTGGGCAGCTCAGCTGGTGCTGTTCCCTGTCCTTGGGCACTAGCTGGACGCTGGGCCCAGGCCAGCCCCCTGTGACCCTGCTTGTCTGCCACCTGCAGATGTGGCCGAGGAGGCGGGCTGCCCCCTGTCCTGTGCAGTCAGCAAGAGACGGCTGGAGTGTGAGGAGTGTGGCGGCCTGGGCTCCCCAACAGGCAGGTGTGAGTGGAGGCAAGGAGATGGCAAAGGTAAGCCCTGGAAACGCCCAAGGGAGGCCTGCAGGGGCGATGGCACCGGTGGAAACGGGGTCCTGGGGCCCTGCCAGCCTGGGGTGGCTCTCCCTGCTCCAGGTCTGCTTCTGGCACCTCATCCCCCATGTGGCTCTCGATGCCAGCATAGCGGGCAGCAGTGCAGGGCTTGGGAGAGGGCTTGTGAGTACAGTGAATGGTCCCCAGGCCGGATTCACTCTGGACTTGGGAAGGTCTGAACCAAAGTTGGGATGTGCTGGGGACAGAATGGCGTTTTTCTGGGAGGTCCTCGGCCAGGGGATGTGGTGTGGGCAGGGGACTCATTGTCTGCATCAGCCAGAGGCCAGCCTGGGTGTGCCCACCACCATGAGGGGCCCTCACCATGCAGCCCTGAGAGGGTCCCGGCCTCTTTGCTGTAAGGGCCACCTGTGTGAGGAACCCCCCATACCTCCTCTCCCATAAGCCATGGCTCCCCAGGATGCTTCCGCTGGCAAGGCTCTGTATATGGTGTTTCCCTACTCAGGCCTCCAGTTGCTCCTCCCTAGAGGGGCAGGATCTGCCTAGGAGGTGGTGGGGGCGTGTGGCGGGGCTCCCACATGGGTGACAGCCTGCTGTGTGTCCTGTGCAGGGATCACCAGGAACTTCTCCACCTGCTCTCCCAGCACCAAGACCTGCCCCGACGGCCACTGCGATGTTGTGGAGACCCAAGACATCAACATTTGCCCTCAGGACTGCCTCCGTAAGCAGGGTTTAATCAGGGCATGGGAACAGGTAGGAGATAGTAGGGGAAACCTGGATCCCACAGGCACTTCAGCCAGAGTTGCCAGGGCTGTCAGTTCTATGCATCAAGCTGAGCCTCCTGTGCATTTCAGCATCACCCTAGCCATGGGGAGGGAGCAGGCAGGGTCAGGGACAGGGGGAAGGCAGGGACCCACAGACTGTCCAGGCCCCTGCTGAGGTCCCAGAAGTCGGCACACACAGATTTCAGAAGCAGAGAATGGTCAGTAGGGACACTGACAGGGAAAGTGCGGCCCTGAGCCAGACGAGGGACACTGCAATGTGCGGGTCAGGCCACCAGGCTCCAGTTTTGGAGGCAGAGTCCTTTGTTCAGATGAAATGTTAGGAGGGGGCCTGGCTTCACCCATGGCTTCAGAAAGGCACTGTGACCAAGCCCTGCCCGGCTAAGCCAAGCTGCTGGGCCCCTGGCCTCACTGGGCCTATGCTTGCGACACCAGTTGGGGAGGGGGCTCCTTGGGACACTGCCCTGGAAATATGGGCGCCTGGGGTGGTCAGGCGCCCCAGGAGGCTGAGTGGGCTACGTCTGCCCTCAGGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGGGGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGGTGAGTGGGTGGCGGCCGGGACCACCACCACCTCCCAGCCCCACAGAGGTCTCAACAGCACATCTGAGGTCCCAACAAGGGAGGAAATTGCTGGGAGGCGAGTGGGCCCCATGAAACTTCCCTCCCTCCCTCTGGGCCTCTGTTACTCCACCCAGGAGAGGGGCCAGGGCCCCTGTAAAGTGTCTTCTGGCCATAAGTTCTATGATGGACAGGCCAGAAAAGCAGTTCTTCCACCAAACAACTTGTCAGCCTGACAAGTCACTGTCCCTGTGACCATGCAGCTGGGACCCACCCAGGAACACATTTCAAGGTCAGCAGGTATGGTGGGTTGCACAGCCACACTGACTACACTCAGGGGTGCTGTTCTGCCTGAGCATAGGGACACGTTTCTGTCATTGAGTTTTCTGGTATTATATAGCCCTACGTCCCTAGCCACTTAGCATTTTCATAAAGAAAATGCCAAAGACATTTGGAACAGAGGAAAATTTTGACCTCCCCTGCCAGCCCTCCAGTGCCAGCTGGTGTAATGAGCACAGCCTCTGCTGTGTGACCTTGGCAGGCTGCTCAGCCTCTCTGAGCCTCTGTCTCCATCTGTAAGAGGGCAATAGTGGTCTAGGAGGGGGCAGTAAATGGCAGTACCCATGCTCGATGGGGTGTTCTCAGGCCTTCCCACACCTCCATGGCCACTTCCCAGCTGGCGCGGACACGGCAGGCTGGAGAGCCATGAGGCAGAGCATACGCAGCCTGTACCCAGTGGTGCCGAGCCTCTGGCGGTGCCAAGCCTCACACCACCCCCACCCACAGATCCACTGTGCGACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTACCACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTGCCCGCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGTGAGGGTCCCTGCGGGGCAGGGAAGATCCCCTGCCCTCCCCAGCTGCCTTCCAGGGAGGGAGGCCAGCTGGGGAGACAGAGGCCATCCTGTGAGGGGCTGCCAACGCTGGGCAGACGAGGCCTGTGTTCTGCCCCCATTTCCATAGGGCGCTGTGTGGGGACAGTCTGTGGGGTGGGACTGTGATGAGGTGCCGTTCCCATCTAGGTGAGAGGCAGTGGTCAGGGTCACAGCATCGGGCAGGGGAGCAGCAGTGTGGATGGAGGGGCACTGAAGTCAGAAGGGGGTGCCTTTCTGGGGAGCCTGGCCTGCAGGTCTGCATGTGCTACTCAGAGCCTCCAGGCTGTGCCGAGTATCCTGGAGCCTCCTTGTCCCGGCCAGGCAGGCCTCTGCCCTCTCCTGGTGGTGGCCTGCCCCTTCAGTGTTCCTACTAGCACTGTCCAGGGCGCTGGAAGCCAAGCCCAGTTCTGGAAGTAACAGAGGCTCAGAGCCAAGGGTGTGAGTGAACGGTGAGCCACGCAGCTTATGGTGGCGTGAATAGCTCCTCGGCAGGAGCCTCCAGGGAGGAAGCTGAGCACCCAGTGGCCACAGGGCCCTGGCAGTTCCCATCTCAGGCTGGGAGGTGGCCTGGGATTCCTGGGAGGGGCCATATCCCACAGTGCAGCTCAGCCTGAGGCCTCGGCCCTGGAGCCTCCGTTCAGGCAACACCCAGCCCTCGGTAAGGGTGTGAGCCAAGGAGGCCTTCCCAGATGTGGCCACTGCCGCTTCCCCACCAGCTTTCCTAATTGGTGGTCCCCATCCTGGCCTGGCTGCAGCTTAGCCTCATGGCAGGGCTCTAGGATGAGCCACCAGAGTCCTTCATAAACCCAGTGGGTTTGTGTGAGGCTGCCCAGGAAGGCCGCACTGGTCTGGGCTGCTGCTGGCAGAGACCACCACCCTAACCCCAGTCAGCTCCAGAGTCACACTCATCAGCACCAGGTCTTGGACCCATGACTCAACCTCAGTATTTGAGAGGATCAGGTTGATGTCGCCCTCATGTGCTTATTGCAGTCTCTAGAGTGTGGTAAACAGGTTTCCAGTGCCAGCTGTGGAGGTGACAGCGGCAGGGAAGCCATGGCAGTGTCGACACTGACCTTGACTGTGGGTTCCCAGGGAATGTGGGGCCAGACCAGGACAGCCCAGGAGCAGGAGACCTGGGGTGACGGATGCCCAGAGCTGGCACATCAAGGGAGGGTTCCTGGATCATGGCAGGCTTTGGCCTCCCTGGTCAGAGTTCAAGTACTGGGGGCCAGGGTGGGGGTCTGGGAAGGCATCCGGAGCAGTCCCAAGTGGGCCCAATGTGTGGATAGAACTTTGGTGGGAGGGCAGGGTGGTAGTGCCAGCAGGCAGGGTGAGCGGGTGCGTGAGGGCCAGTGGCAGCCCTTGAGGAGCAGTGCTTCCACACTCTGAGGCGGAACATGGTGGCGCCTTTCTTTGCAGGGGTGGCTATGTAGAGAAGTTGTCCTGGACACTTCCACTGTAGTCAGAGGTCCTGGGCTGGGCCTGGTGCTCATTTAGTCCTGGGGCAGGGGTCAGGGGAGACAGTAGACCAGGAACCAGAGAGGGTCGAAGTACTGAGTCCAAGCCATGCTGTGACCACACCTGTCATGTAGCAGCTTTCAGGGGCCTGGCTGTGGGGTCCTGCCCAGGGCAGAGACAGGCAGCGTTGCCGCTGGCTCAGATGACAGCCGGTTCTCTGCACATTGGAACTTGTCCATGGGGCCTCCTTTAAGGGTCTTGCCTTCTTCCTCCCCTGTCATCCTCACACTTTTCCCCCCTCTTCTCCCCCTTCCCTCATTTCCAACATAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGGTACCTGCCAGGCACAGGCACAGTGCCCCTGGGGGAGTCTCCGGGGCGGGGGGCGGGTGAGGCCCCTCCTGCCCAGCATGGGACCCTGAAGAGCCCCCAATGCTGTTCTAGAGCGGCTGCAGTTGGGGGACCCCTACCATGGGCCACTTGGGCCTAGAGAAGCAGAGCGAGGACTTTGCTCTCCCTGGAAGGCTCTAGAGGTGTTGCTGTGCCAGTGCCACTGAAGATCTAAGCTTTAAACATTTAAAAAGCCCTTTGATTTTGAGCTGACAGCTGTCTTCACTCCAGTCTGCCCCATTCATTCCTCTCAGCCCAGTGTCTCCTGGGGTCTTGGTGAAGAGACCACCAGTAAGGACTGGCCCTCAATCTCAAGAGACCCCCATGGGCCTGTCTGGCCTGCATGCCCAGTCATGCCACAAGTTTGGCTCTCGATGGGCACATGCACCTACCCACACAGGCATGCGACTGCACTGAGTAGCCCCCTCTTCTGTGGCCAGGCCCCAGCCCTGTGAACAGCCAGGCTGAATGGCGGTGAGGGAGAGTGGTTGGTGTACATAACAATTATCTGCAGTAGTCGGGGGCTGCACAGCACAGGGTGCTTCCAGATGCCTACCCAGCCCCAGACTGGGTTCACCTCCAAGCCAGTAAAACCCCGGACTCTCCAGGGGCACAGGGAGACCCTTGGATTTCCATTGCAGCCATGCACAGCCCCAGGCTGCCCACACCTGGTCCAAGGGGTCCTGGGGCCCCAACTCCCAACTGTCCTCTCCCTTCCAGACAACCTTTCAGGACAGAGGAGGTGGCACGGCACAGCTGGGCAGTGGGACAGCTGACCTGGGAGGGATGGCTTAGCCATGTGTTCTGACTCTTGGAATACCTTCAGGCCCAGGCACCTGCTGGGCATTCCAGCACAGCTCTGGCCACCATCGGGACGCATGTGCTGGGCAGGTGATCCCTGTGGTGCCTCGTCCTGTTTCCATCATGCCTCTACAGTTAGACTCTCTGGGGAATCATGCTATTCATTAAGAATAAGCCAGAATGTCAGGTGTGCAGTGCACTGGTAACACTGCTTTATCTCAGGTGCTAATGTGGGTCTTCTTGGTAACTAACGGAGTGTGAGCTGCTGACGTGTGTGTGACGGATACATCAGCAGCACAGGAGATGCCTGGGCTCCAGGCTGGCCATCTCAGACAGGAGCGGGAAATGGGGAGCCTGGTCGCGGTGTGTGGACCTCCTTTATGGCTCTCCACCTTCTCCAGGGCCTCTCCCGACAAGTGGGTGTGTGGGTACCCCTCACCTTTCCAGAATGATTAATGCGGGGAATTTCTGTGGACGACTGTCTTCTAAAGACAATGACTACAGGAACATAATGCCACATACACAGGTGGCCCAGCCCTGGGACACTCTGGGGAAAGATCCGGCATGTGTGGTTGCTGGCTCCTCAGGGTGCTTCTTCCTCAGGGTGGATGAGGCCCCTGTCCACTGATCCCAAAGGCTGGGAGAAGCCTCAAGCAGCATCGTCTTTGCAGGCCTCTCTGTCTGAACTTGGGCAAGGCGATGCAGGTCCATCCTGACCTGGTATGGTCATGGAAGGGGCTTCCAGGAGCGATCGTTTGCAACCTGCTCTGTGCTGCATTTCAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGTAAGGCCAGCTGCAGGGTGAGGTGGGCAGCCACTGCACCCAGGCTGGGGGCTCCATACAGCCCTGTTCTCCCTCTTTCTCCCTTTCCCTACTGCTCCTGCCCTGTTTCCTGTTCTCCCTCTTTCTGGAAGCCTGGCTCAGGCCCCAGCCTGGAGCTTGTGTCTAGCTGAGTCCACGGGCTGAGTGGTCACTTTCCATCAGAGGGGCCCCGCGCTAGCGGCACTCCCTGGGCCCACAGGGCTACTCAGAGGTCTCTGGTGTGACACTGCCATGTGTCCTCACCCAGTTCGGGGCTGGGCCCGTGGGGCAGGGAGCTCTAGGAATGGACAGTGCATCCTGGGTACTAGGGTACCCTGGGTACCACAGGGCACCAGGTGTGCTGTGACCTCAGGTGACCCCAGCCCCGCCCTGCATGGCAGGAACATTGTCACCATTTCTCAGATAAAGACCCAGGAGACCAGCCTGGTTTGTTGGTTTTCCAAACCACCATGCTGCTCAGGGGCTTCCCAGCATGCGTGTGTGGGTGTGTGCGAGAGGGATAGGGAACCCAAACACCGGGAGTGCGCAGCAGGCACTGTGGTCGGCACCAGTAGAGTTGGAGGCTGGGCCTGGGACAGGACAGGTGGGAACAGGGAGCAGGCTGTGTGCAGAGCCCAGCGCCAGGCAGGAACCCTTGCATCTGCGCAGGCCTCTGCCTCCATCAGCATCCCCAGCCTGCACTGGGGCAGGACCCAGGAGGCAAAAAGGCTTGGCGTCCTAGCATCAGGGAGGGGTGCCTCCCAGGGCAGTGTCGCCTGCCTCAGGCACCTCGAGAAGGAGGCACCCACACGAGCAGCAGGAGGCAGAGAGCAAGTGGTTCAAGAGAAAGCTGAGGCTTCAAGGTCTGCGCTCTCCACAGAGCTGCAGCAGTGCTGCCTGAGGCAGGGCTGTGTCCACCCCCTTACTCATTGGGTGGCCGGGCCTGGGGACCCTGCGGCCTCCCACCCCTGGCTCCTGGAAGACCCAAGCTGCCTGACCCGCACGCCCAGGGCCCCCTCTCTCCGCCCCCAGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGGTGCGTGCATATGGCTCTGCACCCAGCCAGCCCCGGCCAGGCCACACCCTGACCCACCACGCCCCTGCCACCCACACCCTGGCCTGCCACTCCCCCACCATGCCACACTCTAGCCCACCATGCCCCTGCCATGGCATGCCATGCTATGGCTCACCACGCCCCTGCCATGTCACACCCTGACTCCACCACGCCCCTGCCATGCCACACCCCCGGCCCAGGTCTCACCAGGCCGCTACCCGGGCCACACACCACCCCTCTGCTGGTCACACCAGGCTGAGCCAGTGACCGCTGCTGCCTGGCCATGGCCTGACGACTCGTGCTATTTTTCCTCACAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGTGCCCAGTCCCGGGGATGAGGCGGGGCTCCCAGGGATCCCAGGTGCACCATGGGGCAGGCAGTGCCCTTGGGAAGCCTAGGAAAGATACCGAAGATTAGTGGAGCTCTAAGCTTTTTATAGCCCTCACCCCAAATCTTTCTGACCCTGGGTCCCCAAGGACCCAATTAGAACTCCGCTCAGCCTCTGCCATGTCCTTCTCCTCCAGGGCCTCCAGGGCACCCCTCCCTGGCAGCATACTGACCCGAGGCCCTTGCCGCACTTTTCAGAGGCCACCTCATGCTGCGGAACTAACAGTCCTCTTCTGCAGAATAAAGGTCACCGTTCTGATATGACCTTAGCTCTTTTCTCAAAGAAGGGTGGGATGAAATTAGCAGGATCGTCATTCTTTGCAAAAAGGAATGAACTGCTTTACAAGTGAGGCTTCTCCCGCACAGGGGCCTTGGACACTGGGCTGGGTGAGTTTAGAGGCATAGGAACCCCCTGGACAGGATCCAGAAACGCAGCCCAGCTTTGTCCAAGTCTATGAAACAGGCAGTGGGCACCCTTGGGGACACCTGGTTCCCTACCATGGTCCTAGTCCCGGGACAACTGCCTTGGCCCTCTTAGTTTTTCTGCCCATGTCAGCCCCTCTCCTGCAGCCTCCCAGTGGCAGCCCAGGCAGGGCAAGTTCAAGGGGCTGCTCAAAGGCCATGCCGCCCAGACGTTCAGAGCAGACCCTGCTCAAAAAAGAAGAAGAAGAAAAAAAAAAACCACAAAAGGCGACTTCCTATGATTCAGCTTTGCTCTGAGGGGTCTGGAGAAGCCATTTGTGTTGCCAGGGGTTGTGAGCTGTTCCGTTTCTTCTGGGGTTTCCCTTGTGACAGCAGATCTCAGAACTGCTGTGGGGGGAAGTGGTAGGGGCTGGCCCCTGCCCTGTGGAGGGTGTGGACAGAGCCTTCCTGTTGATGCACTGGTCCTCCAGGGAGAGAAGCTGAAGGCATTCTTATACAAGACGTGCAGGCTACACTGTCACACACTGCTGCCAAGACAGCCACACTGCACTAAGGACATAAATCCCTCATGTGTTTAAGTAAAAGAAGTGACAGTAAGATTGTGTTCCAACCCAAGGCACACATTTTAAAAATGGACTTGCACCTTCAGGCTTGTCTGTGGAGAAGCTGTTTCTCAAGTCACCCTGGAAAGGATTTGTTAGGTCAGACCCCAGCACTGATGAGGGATGTAGGGGGCTGGGGGCACTCATTCAGAGATGCTAAAAGCACCCTGCAATACAATAAGAGAGAAAAAACAGCCTCCCCCAAGGCACACAGACAAATCCCTTCCCTCAAGGCTCCTTCAGTGTGGTAGCTGCTGGCAAAGTGCCCAACATGGAAATGCTAGATGTTGGTTTCCCAAACACATTGGCCCTCAGAACCCCAGGGGAGATCTTGCAGGGGGAGTTCCAGGCCCATGCATAGGGAAGCACTGCTCTGCACTACCAGCAGGCCTGTGGCATGTGACAAGCTGGCCCTGTGTGCCTGTGGGTGGGCAGCTGACTCCCGCCAGCATCTCAGCAATCCACAGGAGGTTCAGGCTGGAGCTCCAGCCCCTTCAAAGATGTGTGTGGCCAGTTCTGTGCCCAGGAGTGTCTACAGCACTCCTCTGGTTACTGAAAGCTCAGGGATAGGGCCTGGCCTTCTCCTTTACCCCTCCTTCCTAGAGAGTTAGAGTAACTTCAATGTCTTTATTCCATCTTCTCTTTAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTGTAAGTGTGGGTGTTGCTCTCTTGGGGTGGAGGTTACAGAAACACCCTTATACATGTAGTGGGGCCACGACGCCCGTCTGTGCAGCTTGGCCAGGGAATTGCACTGGCCCTGAGCACCTGTCTGCAGTGCTAGCCCTCTGCAATGACCCCCTCACTGAGGGGCCTTCATGATGTGTTCGTGAGGCAAATGGCTGGGCCAGGCCGGGCTGCAGTTCTGAAAGCTCCGGTAGAGCATGAGAGCCGAGCAGGTGGCCAGTAACCCAGCCTCCCCCACCCTTGCTAGTCCCATGCCTCCCTCTGGGTCCCTTGGTGACTCAGGCCCAGCCCAGCAGTTACCCTCCTGTGGTCCTGAGTAGGGCTTTGGGCTCAGGCAGAGCACCCAGTGACTTGCCCCCACCCACAAGTGGAGCTTGGGGACTCCACCTGAAGATGGCCTTGTGTGAGTTTATAGATTGGTGTGCCCCAAACTGCTCAAAGGTGGAAGCCAAAATCTCATTCTTCCAGGTCCAATGACAAGAGCTGATCACTTTTAAAACACAGGATTCTTGCCTCTAAAGTGTTCTACAGTCAGCAGAGGTGTGATGTGCCTCTCTTTTTTTGTGGGGGGAGGGGATAGGGTCTCACTCTGTCACCCAGGTTGGAGTGCAGTGGCGCAATCCTGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCGATTCCTGTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACGTGCTACTTCGCCTGGCTCATTTTTTTGTATTTTTTGGTAGGGACAGGGTTTCACCATGTTGGTCACACTGGTCTTGAATCCTGACCTCAAATGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGAGAGCCACCACGCCTGGCCAACATGTGCATCTTAAATACTGTGGGCTGTGAATAAGCAATTGGACAACAGCTTTCCGATTATATAAGCTGACTGTAGGCTAGTTGGAAAAGGCAGAGAAAAGCATAAAGAAGAGACTGAATGTCATTGGACCACACCGCCCAGTGACCTCTGGCTGCCCTCTGGTGTGCTCCGTGGTGTGCACATGTATGCTTTTTATTGCCCTAAATGGGCTCATGCGATGCTGTTTTGTGATATGATTTTGTTCCCATTGCAAAGCGAGTTTTCCTTCACAGTTAAAATGTTTTTCTATAGCTTTTTTTCCTTCTAAGATTTTATGAAATTTTCCAAGCACATAGAAATGGCAAAAGAACTATACAAGGCACTCTGAGTCTGGTGGCCTGCATTCTCACCGCTTTAAGTGTGAGAATCTTAAGAATTATTAAGATTAATTCATGATATTAATTAATGTATCATTAATTCATTAATCATGAATTCATCTTAAGCCTCATGTGTCCCTTGTGCGTGTGGCTGCTCTGATGGGAGTGGCTTGGGCAAGGACTTCAGCTTCATGGAGTAGGGGCCAGGCAGGCAGGCAGCCCTTCCCCACCTTCATGCTACATCCATCTGAGCAGCCAGACCCAGGCTGACATCTGTGAGCATCTGTGCTTGAAGCCGACAGGGTCAGCAGGTGCTTGGTGGTGGGGGTGGATATCTGGGCCCCCCGGAGGGCTCTGTGAGGGCCAGGTGGAGCCACTCACTGGTCCTTTCACTCTCTGCAGATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTGAGCGGGGACTGGCTTTGGCCCAGCCTCACTTGGGAAGGGAGGGGACATCTGTGTGCATTCCCTCCCCATCCAGAGCAGCCCCAGGAGAAACCAGGAGAAGTGGGGGGTGGGGAGTGGGCAGGGCAGAGGTTAGAGAGCCATCCTTGGGTGTGGCAGTAGATGCTGGGGGTCCTACCCCACTGAGGGCTGGTGGGCTTCCTAGGGGGTCTTATAAAAATGAGTGAGAGCAGAGACTGGTGCAATGCAAGCTCAAGGGCTGAGAGCTGTCCCAGCAGGACACTTAGGGAGGAGAAGGTAATTCCAGATGGCCCAGGGGGCACGTGTTAAGGGGTGCCTGAGTGGAGGTGCAGAGCCAGGCAGGGGCAGCCTGGGCTGCAACCTGAGAGGTTGAAACCTTTACACTCTCAGGGGAGATGGTCTTAGAAACCAGGCTGAGAACAGATGAGAAAGGGCTGCCCAGAGGCAGAGATGCATGGTACATGCATTCCACAGAGTGTGCACACTGCTGGGGCGTGGAGGGGGCATGCTGGGCCGAGAAGCCAGGTACCACCTCCCTGGGCCCCCAGCTGGTGGCCAGCTGGAGCGCTGTGGTCTGCCTGGGCACCCAGGCAAGCAAGGACGGTGCAGGACAGACGTGTGATTGCCAAAGGTTCTTGTTTGTCTGTCTCCACACCTAAAAGCCCTCAATCAATTCATTCTTCTTGAGAGTTTTAAGGACTGGCACTTCTCACTTAGCTGCCAGAGCAAGCATAGTATCCAGTGAGCTGTTTACCAGTGTCTTTGCAAGGGAAGTAAAAATGAATCTCCCTTGGAGGGAAGGGAAGCTTGTAGGATTCTGGACCACAGCTCTGAGAGACCTGAGCACAGTGGCCCACGGGCTGGGATCCTGCAACAGGCCATGCCCCAGTCCCACGAGGCTCAGAGATGTCAGCGATGCAGAAATAGCTTTGGAGTTGGAGACAGAGCACACTGGGCCCAGGGTACAGGGCAGGGTGCGATGGCTGTGGTGGGCTGTCCTTCTGAGACCTGGCCCTGCTTGGATCATATTGGCCTGTCTGCTCTTCCCACCAGGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGTGAGTGCCTGGGTCCAATTCCCACAAGCTGAAAGTGGCTTGGGGAGACTCCAGCCTCACCCCAGGGCAGTAGTTTTAGCCCTCAGAGTTCCCAGTGTGGGGCCACAGTGGGATTGTGCAGAGAGAGAGAGTCATGCTCTCCCCTGCATGCAGACAGCAGATTGAACCCTTCTCAGGCCAGGCCGCTTGGGCTTCTTTTCAAGTCATGAAGAAACCAAGATTCTTGACATTTAGGAAAAGCTCTCTACAGACAGGCATGGGAGGAAAATATTCCAAAGCCAAAAAGAAATAGTTTTCCATAATGGAAAATGAGAAAGTTGAGTTAAAGCAAGTGCCCAAAATTCAGATGCCCAGAGGGGGGTCCGGCTGGAGGAGGGCAGTGAGTAAGGAGCAGTGGAGACTGTGGCAAACAGCCAGCCCCCTCCAAAGGGTTCCTTGCTGGAGTACCTGTGGCCTGCAGAAAAAGGAGCCAGGAATGGGCTGGGTCTTCTGAATTTTATGAGGTTTATGTTGTCTCCCAGTTTTTATTGTTAACAATTCATTTAAATTTCCCAGAGCCGAACGCAGGCCAAACAAAGCATATCGGGGGGTGGCCAGAGTCAGCCTGTGTGCCTGGAAGTACAGTTTGTGAGGTCTACACATTTTCAACCAATATTCATCAGGCAGCTGCTAGGACCCATACTATGTCTCAGAGGCTGGGAATGCAGATAAACAAGACCAGCACAGCCCTGCCCTCACGGGGTTTACACACAGGCCTTGTCTTAACATTGGCACATTTACTGAGTTGTCACTTCTTCCGACTTGGATAGCGGGATGCAGGACCTAGGACCCCATAGGAAAACTTCACATCACTGTCTCGCTTGGATGAAAACTTCAAGTCCTGAGAATGCAGCGTTGTTCAAAACAGAAGCGATCACTGGTGCTGGCCTTCCTAGAACAGTGCTGAGAAACAGCCGGGAAAACGCTGGGCCCCTCTGTGCACATTCAAGCTGGGCATTGAAAGGAGCAGACGCCAGTGGCCCCTCGTGCTGGGGAGCCCGTGCCTGTAGCAGGGTCCTGTGCACCCTGACAGCGCTGTCAGATTTCAGAACTCAGCCCTGACGTGACGTTCTAGATGGCAGGGGTCCTTGGGGAAAGCTGGAAAACATCCTGCAGGCTGGGGCTGCGTCCTGGCATGTGGCTGCAGTGGGCTCCCCCAGAGCCCAAGGGTTTGTCAGCGGGCTGGTTCCGTGCTGCCCATCTCCGGGTTGGGCCAGGGGCAGCTAGATGAGGCGTCCCCCAAGGCTGCCCTCCAGGCCCTGGAGATAAGACGCTGAGGGAGCACATTTCTTTCCCCAGGGAGGTGACTTTCCAGGGGAAGAGACAGAATAGACAACACCCAGGGGAGTGATGGGGACCTCAGAGCAGGACCAGGCCAGCCAGGAGTCCTGGGAGCTCTATGCAGCCTGGCCCTGGTCTCTTGGAGAGGTCAGGAGATTGGTGCGAGGTGGAGACACAGCCAGAGCCTCTGCCCTGAGGATGGCTTGTTGTATACTGAGTTGTATCTAGTTGTGGCACATGGCTTGGAGTGACCGGCCATCTCTGTCTTCCAGGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTGATTAAATACTAGAAATTTTTTCTGTTTCCTAACTTCATCATTGATTGTTTGAAATCTTGGAGTTTCAAGCATTTTTTTCAAGCTGAGACGGTTCCTTTTGCATGCCTCCTGACTCACTGACTCCTCACTGGCTTTGTGTCTAGTGCCACACTCCATTTGTGCTGACGATGCTATGAGGCTGGCCCGTGTGCACCCTCGATTTGGAAGGTCCTCTTCTCCGTTGTAGGCTCAGACAACAGACGAGTGCCTCCTTTACGTTAGAGAATGTTTTATAGAACGTTTCCGCTGCAGTAAGCCATTGAGTGCAGCAGTGTGCTGTTGCCCTACACTGCCTTAGAAAAAGAGTTAAGCAGTTCGACAAATATACATCAGATTAGAGAGTCTCAAGTTCATAAAAGTCAAAATTGGTAGTGTCTGTTAAGTTACATTTACCAAGAGAGCACATGATATTTCCCCTAACTATAACAGTGTTTTTGGAAACCTGGAACACAAAACCATTAATATAATTGGCACAGAAACCACGAGTTTGGTTTGAACATCAAAGGGAGTTTTGCCAAGGCCTTACTGTCTGCACTTGAAGTTTTGGTTCTTCAGTGCAGAACAAATGATCTGTTTTCATTTTTAGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGAAAATCAGTTGTGTAAATAAAATCATGTATCATAAAA" ;
sio:SIO_000205 :genesym-RET ;
sio:SIO_000216 :DSI-gene ;
sio:SIO_000216 :DPI-gene ;
sio:SIO_000068 :wp-WP2586 ;
ncit:R178 :var-rs121913306 ;
ncit:R41 :org-9606 ;
sio:SIO_010078 :prot-P07949 .
:genesym-RET
a &lthttp://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43568&gt ;
rdfs:label "RET" ;
rdfs:comment "Gene Symbol for gene 5979" ;
sio:SIO_000300 "RET"^^xsd:double .
:wp-WP2586
a &lthttp://vocabularies.wikipathways.org/wp#Pathway&gt ;
rdfs:label "Aryl Hydrocarbon Receptor Netpath Pathway" ;
rdfs:comment "Pathway associated with gene 5979" .
:DSI-gene
a &lthttp://semanticscience.org/resource/SIO_001351&gt ;
rdfs:label "DisGeNET disease specificity Gene Index" ;
sio:SIO_000300 0.418^^xsd:double .
:DPI-gene
a &lthttp://semanticscience.org/resource/SIO_001352&gt ;
rdfs:label "DisGeNET disease Pleiotropy Gene Index" ;
sio:SIO_000300 0.724^^xsd:double .
:var-rs121913306
a &lthttp://purl.obolibrary.org/obo/SO_0001060&gt ;
rdfs:label "Variant rs121913306" ;
rdfs:comment "Variant associated with gene 5979" ;
sio:SIO_000216 :DSI-variant ;
sio:SIO_000216 :DPI-variant ;
sio:SIO_000061 :chr ;
sio:SIO_000061 :chrPos ;
:consequence "stop_lost"^^xsd:string ;
sio:SIO_001403 :gene-5979 .
:DSI-variant
a &lthttp://semanticscience.org/resource/SIO_001351&gt ;
rdfs:label "DisGeNET disease specificity Variant Index" ;
sio:SIO_000300 0.846^^xsd:double .
:DPI-variant
a &lthttp://semanticscience.org/resource/SIO_001352&gt ;
rdfs:label "DisGeNET disease Pleiotropy Variant Index" ;
sio:SIO_000300 0.107^^xsd:double .
:chr
a &lthttp://semanticscience.org/resource/SIO_000899&gt ;
rdfs:label "Chromosome position of the variant rs121913306" ;
sio:SIO_000300 10^^xsd:integer .
:chrPos
a &lthttp://semanticscience.org/resource/SIO_000791&gt ;
rdfs:label "Chromosome position of variant rs121913306" ;
sio:SIO_000300 43120119^^xsd:integer .
:dis-Multiple%20Endocrine%20Neoplasia
a &lthttp://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057&gt ;
rdfs:label "Multiple Endocrine Neoplasia" ;
sio:SIO_000008 :dis-semantic%20type%20T047 ;
sio:SIO_000095 :dis-class%20c19 ;
sio:SIO_000068 ::orpha-Multiple%20Endocrine%20Neoplasia .
:dgassoc-Multiple%20Endocrine%20Neoplasia%20gene%5979
sio:SIO_000628 :gene-5979, :dis-Multiple%20Endocrine%20Neoplasia ;
a sio:000983, sio:SIO_000897 ;
rdfs:comment "Association between disease Multiple Endocrine Neoplasia and gene 5979" ;
rdfs:label "Multiple Endocrine Neoplasia - Gene 5979" .
:dvassoc-Multiple%20Endocrine%20Neoplasia%20rs121913306
sio:SIO_000628 :var-rs121913306, :dis-Multiple%20Endocrine%20Neoplasia ;
a sio:SIO_000897 ;
rdfs:comment "Association between disease Multiple Endocrine Neoplasia and variant rs121913306" ;
rdfs:label "Multiple Endocrine Neoplasia - variant rs121913306" .
:score-dgassoc%20Multiple%20Endocrine%20Neoplasia%20gene%5979
a ncit:C25338 ;
rdfs:comment "Score of the association between disease Multiple Endocrine Neoplasia and gene 5979" ;
rdfs:label "Score Multiple Endocrine Neoplasia - Gene 5979" ;
sio:SIO_000300 0.5^^xsd:double .
:score-dvassoc%20Multiple%20Endocrine%20Neoplasia%20variant%20rs121913306
a ncit:C25338 ;
rdfs:comment "Score of the association between disease Multiple Endocrine Neoplasia and variant rs121913306" ;
rdfs:label "Score Multiple Endocrine Neoplasia - Variant rs121913306" ;
sio:SIO_000300 0.01^^xsd:double .
:dis-semantic%20type%20T047
a sio:SIO_000326 ;
rdfs:comment "Semantic type of disease Multiple Endocrine Neoplasia" ;
rdfs:label "Disease or Syndrome Semantic Type T047" .
:dis-class%20c19
a obo:HP_0000118 ;
rdfs:comment "Disease class of disease Multiple Endocrine Neoplasia" ;
rdfs:label "Endocrine System Diseases class C19" .
:orpha-Multiple%20Endocrine%20Neoplasia
a &lthttp://www.orpha.net/ORDO/Orphanet_557492&gt ;
rdfs:comment "Orphan disease associated with Multiple Endocrine Neoplasia" ;
rdfs:label "Orphan disease Multiple Endocrine Neoplasia" .
:prevalence-class%20Multiple%20Endocrine%20Neoplasia
a &lthttp://www.orpha.net/ORDO/Orphanet_409967&gt ;
rdfs:comment "Annual incidence of orphan disease Multiple Endocrine Neoplasia" ;
rdfs:label "Prevalence class or Annual Incidence" ;
sio:SIO_000300 "Unknown"^^xsd:string .
:prevalence-Multiple%20Endocrine%20Neoplasia
sio:SIO_000628 :orpha-Multiple%20Endocrine%20Neoplasia, :prevalence-class%20Multiple%20Endocrine%20Neoplasia ;
a :Prevalence, sio:SIO_000897 ;
rdfs:comment "Association between orphan disease Multiple Endocrine Neoplasia and the prevalence class 0" ;
rdfs:label "Multiple Endocrine Neoplasia - Prevalence class 0" ;
:geo "Europe"^^xsd:string .
:prot-P07949
a ncit:C17021 ;
rdfs:comment "Protein P07949 encoded by gene 5979" ;
rdfs:label "Protein P07949 - Gene 5979" ;
cco:proteinSequence "MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS"^^xsd:string ;
sio:SIO_000062 :ppi-P07949%20O14492 ;
sio:SIO_010079 :gene-5979 ;
ncit:R45 :org-9606 ;
sio:SIO_000291 :target-CHEMBL1941%20CHEMBL30%20Prot%20P07949 .
:ppi-P07949%20O14492
sio:SIO_000132 :prot-P07949 ;
a :Ppi, sio:SIO_000897 ;
rdfs:comment "PPI between protein P07949 and protein O14492" ;
rdfs:label "PPI P07949 - O14492" ;
:confidenceValue "GOLD"^^xsd:string .
:org-9606
a ncit:C14250 ;
rdfs:comment "Organism associated with taxonomy id 9606" ;
rdfs:label "Organism 9606 - Homo sapiens" ;
sio:SIO_000291 :target-CHEMBL1941%20CHEMBL30%20Prot%20P07949 .
:drug-CHEMBL30%20Multiple%20Endocrine%20Neoplasia
a &lthttp://rdf.ebi.ac.uk/terms/chembl#Substance&gt ;
rdfs:comment "Drug with code CHEMBL30 associated with disease Multiple Endocrine Neoplasia" ;
rdfs:label "CIMETIDINE" ;
:chemicalStructure "CN/C(=N/CCSCc1nc[nH]c1C)NC#N"^^xsd:string ;
:inchiKey "AQIXAKUUQRKLND-UHFFFAOYSA-N"^^xsd:string ;
:synonymous "ACID-EZE"^^xsd:string ;
cco:atcClassification "A02BA01"^^xsd:string ;
cco:substanceType "Small molecule"^^xsd:string .
:ddassoc-CHEMBL30%20Multiple%20Endocrine%20Neoplasia
sio:SIO_000628 :drug-CHEMBL30%20Multiple%20Endocrine%20Neoplasia, :dis-Multiple%20Endocrine%20Neoplasia ;
a :DrugDisease, sio:SIO_000897 ;
rdfs:comment "Associatioon between drug CHEMBL30 and disease Multiple Endocrine Neoplasia" ;
rdfs:label "CHEMBL30 - Multiple Endocrine Neoplasia" .
:dd-therapeutic%20CHEMBL30%20Multiple%20Endocrine%20Neoplasia
a :DrugDiseaseTherapeutic, :ddassoc-CHEMBL30%20Multiple%20Endocrine%20Neoplasia ;
rdfs:comment "Therapeutic use of drug CHEMBL30 to treat disease Multiple Endocrine Neoplasia" ;
rdfs:label "Drug Disease Therapeutic CHEMBL30 - Multiple Endocrine Neoplasia" ;
sio:SIO_000300 "T"^^xsd:string .
:target-CHEMBL1941%20CHEMBL30%20Prot%20P07949
a &lthttp://rdf.ebi.ac.uk/terms/chembl#Target&gt ;
rdfs:comment "Target associated with drug CHEMBL30 and protein P07949" ;
rdfs:label "Histamine H2 receptor target" ;
cco:targetType "SINGLE PROTEIN"^^xsd:string ;
sio:SIO_000292 :org-9606 ;
sio:SIO_000292 :prot-P07949 .
:dtassoc-CHEMBL1941%20CHEMBL30
:hasTarget :target-CHEMBL1941%20CHEMBL30%20Prot%20P07949 ;
:mechanismHasMolecule :drug-CHEMBL30%20Multiple%20Endocrine%20Neoplasia ;
a :DrugTarget, sio:SIO_000897 ;
rdfs:comment "Association between drug CHEMBL30 and target CHEMBL1941" ;
rdfs:label "Drug CHEMBL30 - Target CHEMBL1941" ;
cco:mechanismActionType "ANTAGONIST"^^xsd:string .
:phenotype-indication%20C0002736
a :Phenotype ;
rdfs:comment "Phenotype C0002736 associated with drug CHEMBL30 as indicatication" ;
rdfs:label "Amyotrophic Lateral Sclerosis phenotype" .
:phenotype-sideeffect%20C0001824
a :Phenotype ;
rdfs:comment "Phenotype C0001824 associated with drug CHEMBL30 as side effect" ;
rdfs:label "Agranulocytosis phenotype" .
:phenotype-ddi%20C0003467
a :Phenotype ;
rdfs:comment "Phenotype C0003467 associated with drug CHEMBL30 as DDI" ;
rdfs:label "Anxiety phenotype" .
:dpassoc-indication%20CHEMBL30%20C0002736
sio:SIO_000628 :phenotype-indication%20C0002736 ;
:indicationHasMolecule :drug-CHEMBL30%20Multiple%20Endocrine%20Neoplasia ;
a :DrugPhenotypeIndication, sio:SIO_000897 ;
rdfs:comment "Association between drug CHEMBL30 and phenotype C002736 as indication" ;
rdfs:label "Drug CHEMBL30 - Phenotype C002736" ;
cco:chemblId "CHEMBL30"^^xsd:string ;
cco:highestDevelopmentPhase 1^^xsd:double .
:dpassoc-sideeffect%20CHEMBL30%20C0001824
:hasPhenotype :phenotype-sideeffect%20C0001824 ;
:sideEffectHasMolecule :drug-CHEMBL30%20Multiple%20Endocrine%20Neoplasia ;
a :DrugPhenotypeSideEffect, sio:SIO_000897 ;
rdfs:comment "Association between drug CHEMBL30 and phenotype C001824 as indication" ;
rdfs:label "Drug CHEMBL30 - Phenotype C001824" ;
cco:chemblId "CHEMBL30"^^xsd:string ;
cco:highestDevelopmentPhase 0.01^^xsd:double .
:dpassoc-ddi%20CHEMBL30%20C0003467
:hasSideEffect :dpassoc-ddi%20CHEMBL30%20C0003467 ;
sio:SIO_000132 :drug-CHEMBL30%20Multiple%20Endocrine%20Neoplasia ;
a :DrugPhenotypeSideEffect, sio:SIO_000897 ;
rdfs:comment "Association between drug CHEMBL30 and phenotype C003467 as DDI" ;
rdfs:label "Drug CHEMBL30 - Phenotype C003467" .
:dispassoc-CHEMBL30%20Multiple%20Endocrine%20Neoplasia
sio:SIO_000628 :phenotype-indication%20C0002736, :phenotype-sideeffect%20C0001824, :phenotype-ddi%20C0003467, :dis-Multiple%20Endocrine%20Neoplasia ;
a :DiseasePhenotype, sio:SIO_000897 ;
rdfs:comment "Association between disease Multiple Endocrine Neoplasia and the different phenotypes depending on the effect of the used drug" ;
rdfs:label "Multiple Endocrine Neoplasia - Phenotype Effect" .
</pre>
</div>
</div>
<!--CROSSREF SECTION--> <!--CROSSREF SECTION-->
<div id="crossref"><h2 id="crossreference" class="list">Cross-reference for SEM-DISNET classes, object properties and data properties <span class="backlink"> back to <a href="#toc">ToC</a></span></h2> <div id="crossref"><h2 id="crossreference" class="list">Cross-reference for SEM-DISNET classes, object properties and data properties <span class="backlink"> back to <a href="#toc">ToC</a></span></h2>
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