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+{
+ "cells": [
+  {
+   "cell_type": "code",
+   "execution_count": 1,
+   "id": "50a451f7-1809-46d2-973e-74e901d97204",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "import pandas as pd\n",
+    "import numpy as np\n",
+    "import seaborn as sns\n",
+    "import matplotlib.pyplot as plt\n",
+    "import networkx as nx\n",
+    "from networkx.algorithms import bipartite\n",
+    "import nxpd\n",
+    "import funciones_reposicionamiento\n",
+    "import re"
+   ]
+  },
+  {
+   "cell_type": "markdown",
+   "id": "422cca8f-611e-4e02-8fa5-e90641cb3fb2",
+   "metadata": {},
+   "source": [
+    "### Enfermedades estudiadas\n",
+    "\n",
+    "<div style=\"text-align: center;\">\n",
+    "    \n",
+    "| Condition          | Concept ID |\n",
+    "|------------------- |------------|\n",
+    "| Dementia           | C0497327   |\n",
+    "| Bipolar Disorder   | C0005586   |\n",
+    "| Epilepsy           | C0014544   |\n",
+    "| Schizophrenia      | C0036341   |\n",
+    "\n",
+    "</div>\n"
+   ]
+  },
+  {
+   "cell_type": "markdown",
+   "id": "62ae066d-075e-45c9-a878-6b971f837d8a",
+   "metadata": {},
+   "source": [
+    "### Datos"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 2,
+   "id": "ce71be78-0f8c-4f42-ae9e-e730de08e7fe",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "#Cargo los archivos que contienen las matrices de SPL\n",
+    "spl_enf_dis_gen = pd.read_csv('Data/Matrices SPL/SPL enf en bipartita enf-gen.csv', sep=\",\")\n",
+    "spl_gen_dis_gen = pd.read_csv('Data/Matrices SPL/SPL genes en bipartita enf-gen.csv', sep=\",\")\n",
+    "spl_enf_dis_dru = pd.read_csv('Data/Matrices SPL/SPL enf en bipartita enf-dru.csv', sep=\",\")\n",
+    "spl_dru_dis_dru = pd.read_csv('Data/Matrices SPL/SPL fármacos en bipartita enf-dru.csv', sep=\",\")\n",
+    "spl_enf_dse_sym = pd.read_csv('Data/Matrices SPL/SPL enf en bipartita enf-sym.csv', sep=\",\")\n",
+    "spl_sym_dse_sym = pd.read_csv('Data/Matrices SPL/SPL síntomas en bipartita enf-sym.csv', sep=\",\")\n",
+    "spl_dis_gen_proj = pd.read_csv('Data/Matrices SPL/SPL enf en proyectada enf-gen.csv', sep=\",\")\n",
+    "spl_dis_dru_proj = pd.read_csv('Data/Matrices SPL/SPL enf en proyectada enf-dru.csv', sep=\",\")\n",
+    "spl_dse_sym_proj = pd.read_csv('Data/Matrices SPL/SPL enf en proyectada enf-sym.csv', sep=\",\")"
+   ]
+  },
+  {
+   "cell_type": "markdown",
+   "id": "041b026c-bd1b-495d-89c1-2887a43995f5",
+   "metadata": {},
+   "source": [
+    "### Fármacos candidatos"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": null,
+   "id": "4681667a-28e9-45f2-8792-22280a657c8c",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "#cargo el archivo obtenido en la celda anterior\n",
+    "resultados_proximidad_targets = pd.read_csv('Resultados proximidad y targets en módulo.csv', sep=\",\")"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": null,
+   "id": "5b55709c-6c2b-4225-a0e6-d46c5c29a876",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "candidatos_dementia = funciones_reposicionamiento.farmacos_candidatos(resultados_proximidad_targets, \"Demencia\", dis_dru_the)\n",
+    "candidatos_bipolar = funciones_reposicionamiento.farmacos_candidatos(resultados_proximidad_targets, \"Bipolaridad\", dis_dru_the)\n",
+    "candidatos_epilepsy = funciones_reposicionamiento.farmacos_candidatos(resultados_proximidad_targets, \"Epilepsia\", dis_dru_the)\n",
+    "candidatos_schizo = funciones_reposicionamiento.farmacos_candidatos(resultados_proximidad_targets, \"Esquizofrenia\", dis_dru_the)"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": null,
+   "id": "222c2ca3-3711-47b2-a1ec-5d72f7dcd652",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "enfermedades = ['Demencia', 'Bipolaridad', 'Epilepsia', 'Esquizofrenia']\n",
+    "\n",
+    "df_resultados_candidatos = pd.DataFrame()\n",
+    "\n",
+    "# Itero sobre las cuatro enfermedades\n",
+    "for enfermedad in enfermedades:\n",
+    "    # Utilizo la función farmacos_candidatos para cada enfermedad neurológica y concateno los resultados\n",
+    "    resultados_enfermedad = funciones_reposicionamiento.farmacos_candidatos(resultados_proximidad_targets, enfermedad, dis_dru_the)\n",
+    "    df_resultados_candidatos = pd.concat([df_resultados_candidatos, resultados_enfermedad], ignore_index=True)\n",
+    "\n",
+    "df_resultados_candidatos.to_csv(\"Fármacos y enfermedades candidatos de reposicionamiento.csv\", index = False)"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 3,
+   "id": "fb9495ea-efcc-42c0-97f2-e24d0e231ef1",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "#cargo el archivo de fármacos candidatos de reposicionamiento\n",
+    "candidatos = pd.read_csv('Fármacos y enfermedades candidatos de reposicionamiento.csv', sep=\",\")"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 4,
+   "id": "77745258-518c-4642-8b5a-a825b1750390",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "#calculo los SPLs en las tres redes proyectadas entre las enfermedades neurológicas estudiadas y las enfermedades tratadas por los\n",
+    "#fármacos candidatos de reposicionamiento.\n",
+    "id_enfermedades = {\n",
+    "    'Demencia': \"C0497327\",\n",
+    "    'Bipolaridad': \"C0005586\",\n",
+    "    'Epilepsia': \"C0014544\",\n",
+    "    'Esquizofrenia': \"C0036341\"\n",
+    "}\n",
+    "\n",
+    "spls_files = [spl_dis_gen_proj, spl_dis_dru_proj, spl_dse_sym_proj]\n",
+    "\n",
+    "spls_enfermedades_candidatas = funciones_reposicionamiento.spl_candidatos(spls_files, id_enfermedades, candidatos)\n",
+    "spls_enfermedades_candidatas.to_csv(\"SPLs enfermedades candidatas de reposicionamiento.csv\", index = False)"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 6,
+   "id": "ad63dea1-2fb0-414d-b461-a40d728154b4",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "#cargo el archivo con los resultados de la celda anterior\n",
+    "spls_enfermedades_candidatas = pd.read_csv(\"SPLs enfermedades candidatas de reposicionamiento.csv\", sep=\",\")"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 8,
+   "id": "19977544-f4b8-4401-9d16-02e4c65a3e64",
+   "metadata": {},
+   "outputs": [
+    {
+     "data": {
+      "text/html": [
+       "<div>\n",
+       "<style scoped>\n",
+       "    .dataframe tbody tr th:only-of-type {\n",
+       "        vertical-align: middle;\n",
+       "    }\n",
+       "\n",
+       "    .dataframe tbody tr th {\n",
+       "        vertical-align: top;\n",
+       "    }\n",
+       "\n",
+       "    .dataframe thead th {\n",
+       "        text-align: right;\n",
+       "    }\n",
+       "</style>\n",
+       "<table border=\"1\" class=\"dataframe\">\n",
+       "  <thead>\n",
+       "    <tr style=\"text-align: right;\">\n",
+       "      <th></th>\n",
+       "      <th>Fármacos candidatos Demencia</th>\n",
+       "      <th>Total enfermedades tratadas</th>\n",
+       "      <th>Enfermedades en red proyectada enf-genes</th>\n",
+       "      <th>Enfermedades en red proyectada enf-dru</th>\n",
+       "      <th>Enfermedades en red proyectada enf-sym</th>\n",
+       "    </tr>\n",
+       "  </thead>\n",
+       "  <tbody>\n",
+       "    <tr>\n",
+       "      <th>2</th>\n",
+       "      <td>CHEMBL118</td>\n",
+       "      <td>138</td>\n",
+       "      <td>136</td>\n",
+       "      <td>138</td>\n",
+       "      <td>116</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>1</th>\n",
+       "      <td>CHEMBL606</td>\n",
+       "      <td>33</td>\n",
+       "      <td>33</td>\n",
+       "      <td>33</td>\n",
+       "      <td>27</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>3</th>\n",
+       "      <td>CHEMBL1983350</td>\n",
+       "      <td>25</td>\n",
+       "      <td>25</td>\n",
+       "      <td>25</td>\n",
+       "      <td>22</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>4</th>\n",
+       "      <td>CHEMBL254219</td>\n",
+       "      <td>22</td>\n",
+       "      <td>22</td>\n",
+       "      <td>22</td>\n",
+       "      <td>18</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>0</th>\n",
+       "      <td>CHEMBL222863</td>\n",
+       "      <td>9</td>\n",
+       "      <td>9</td>\n",
+       "      <td>9</td>\n",
+       "      <td>6</td>\n",
+       "    </tr>\n",
+       "  </tbody>\n",
+       "</table>\n",
+       "</div>"
+      ],
+      "text/plain": [
+       "  Fármacos candidatos Demencia  Total enfermedades tratadas  \\\n",
+       "2                    CHEMBL118                          138   \n",
+       "1                    CHEMBL606                           33   \n",
+       "3                CHEMBL1983350                           25   \n",
+       "4                 CHEMBL254219                           22   \n",
+       "0                 CHEMBL222863                            9   \n",
+       "\n",
+       "   Enfermedades en red proyectada enf-genes  \\\n",
+       "2                                       136   \n",
+       "1                                        33   \n",
+       "3                                        25   \n",
+       "4                                        22   \n",
+       "0                                         9   \n",
+       "\n",
+       "   Enfermedades en red proyectada enf-dru  \\\n",
+       "2                                     138   \n",
+       "1                                      33   \n",
+       "3                                      25   \n",
+       "4                                      22   \n",
+       "0                                       9   \n",
+       "\n",
+       "   Enfermedades en red proyectada enf-sym  \n",
+       "2                                     116  \n",
+       "1                                      27  \n",
+       "3                                      22  \n",
+       "4                                      18  \n",
+       "0                                       6  "
+      ]
+     },
+     "execution_count": 8,
+     "metadata": {},
+     "output_type": "execute_result"
+    }
+   ],
+   "source": [
+    "#calculo la cantidad de enfermedades tratadas por fármacos candidatos de reposcinamiento en cada una de las redes proyectadas.\n",
+    "enf_candidatas_dementia = funciones_reposicionamiento.distribucion_enf_candidatas(spls_enfermedades_candidatas, \"Demencia\")\n",
+    "enf_candidatas_dementia.sort_values(by=\"Total enfermedades tratadas\", ascending=False).head()"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 9,
+   "id": "a793cc37-4ab0-4a14-af35-4d0d7426e38f",
+   "metadata": {},
+   "outputs": [
+    {
+     "data": {
+      "text/html": [
+       "<div>\n",
+       "<style scoped>\n",
+       "    .dataframe tbody tr th:only-of-type {\n",
+       "        vertical-align: middle;\n",
+       "    }\n",
+       "\n",
+       "    .dataframe tbody tr th {\n",
+       "        vertical-align: top;\n",
+       "    }\n",
+       "\n",
+       "    .dataframe thead th {\n",
+       "        text-align: right;\n",
+       "    }\n",
+       "</style>\n",
+       "<table border=\"1\" class=\"dataframe\">\n",
+       "  <thead>\n",
+       "    <tr style=\"text-align: right;\">\n",
+       "      <th></th>\n",
+       "      <th>Fármacos candidatos Bipolaridad</th>\n",
+       "      <th>Total enfermedades tratadas</th>\n",
+       "      <th>Enfermedades en red proyectada enf-genes</th>\n",
+       "      <th>Enfermedades en red proyectada enf-dru</th>\n",
+       "      <th>Enfermedades en red proyectada enf-sym</th>\n",
+       "    </tr>\n",
+       "  </thead>\n",
+       "  <tbody>\n",
+       "    <tr>\n",
+       "      <th>0</th>\n",
+       "      <td>CHEMBL53463</td>\n",
+       "      <td>198</td>\n",
+       "      <td>197</td>\n",
+       "      <td>198</td>\n",
+       "      <td>164</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>1</th>\n",
+       "      <td>CHEMBL452231</td>\n",
+       "      <td>37</td>\n",
+       "      <td>37</td>\n",
+       "      <td>37</td>\n",
+       "      <td>31</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>2</th>\n",
+       "      <td>CHEMBL1184</td>\n",
+       "      <td>33</td>\n",
+       "      <td>33</td>\n",
+       "      <td>33</td>\n",
+       "      <td>21</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>4</th>\n",
+       "      <td>CHEMBL1201544</td>\n",
+       "      <td>12</td>\n",
+       "      <td>10</td>\n",
+       "      <td>12</td>\n",
+       "      <td>10</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>3</th>\n",
+       "      <td>CHEMBL1465</td>\n",
+       "      <td>7</td>\n",
+       "      <td>7</td>\n",
+       "      <td>7</td>\n",
+       "      <td>6</td>\n",
+       "    </tr>\n",
+       "  </tbody>\n",
+       "</table>\n",
+       "</div>"
+      ],
+      "text/plain": [
+       "  Fármacos candidatos Bipolaridad  Total enfermedades tratadas  \\\n",
+       "0                     CHEMBL53463                          198   \n",
+       "1                    CHEMBL452231                           37   \n",
+       "2                      CHEMBL1184                           33   \n",
+       "4                   CHEMBL1201544                           12   \n",
+       "3                      CHEMBL1465                            7   \n",
+       "\n",
+       "   Enfermedades en red proyectada enf-genes  \\\n",
+       "0                                       197   \n",
+       "1                                        37   \n",
+       "2                                        33   \n",
+       "4                                        10   \n",
+       "3                                         7   \n",
+       "\n",
+       "   Enfermedades en red proyectada enf-dru  \\\n",
+       "0                                     198   \n",
+       "1                                      37   \n",
+       "2                                      33   \n",
+       "4                                      12   \n",
+       "3                                       7   \n",
+       "\n",
+       "   Enfermedades en red proyectada enf-sym  \n",
+       "0                                     164  \n",
+       "1                                      31  \n",
+       "2                                      21  \n",
+       "4                                      10  \n",
+       "3                                       6  "
+      ]
+     },
+     "execution_count": 9,
+     "metadata": {},
+     "output_type": "execute_result"
+    }
+   ],
+   "source": [
+    "enf_candidatas_bipolar = funciones_reposicionamiento.distribucion_enf_candidatas(spls_enfermedades_candidatas, \"Bipolaridad\")\n",
+    "enf_candidatas_bipolar.sort_values(by=\"Total enfermedades tratadas\", ascending=False).head()"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 10,
+   "id": "247f0db4-3993-4e1b-9c42-0369d814e5c0",
+   "metadata": {},
+   "outputs": [
+    {
+     "data": {
+      "text/html": [
+       "<div>\n",
+       "<style scoped>\n",
+       "    .dataframe tbody tr th:only-of-type {\n",
+       "        vertical-align: middle;\n",
+       "    }\n",
+       "\n",
+       "    .dataframe tbody tr th {\n",
+       "        vertical-align: top;\n",
+       "    }\n",
+       "\n",
+       "    .dataframe thead th {\n",
+       "        text-align: right;\n",
+       "    }\n",
+       "</style>\n",
+       "<table border=\"1\" class=\"dataframe\">\n",
+       "  <thead>\n",
+       "    <tr style=\"text-align: right;\">\n",
+       "      <th></th>\n",
+       "      <th>Fármacos candidatos Epilepsia</th>\n",
+       "      <th>Total enfermedades tratadas</th>\n",
+       "      <th>Enfermedades en red proyectada enf-genes</th>\n",
+       "      <th>Enfermedades en red proyectada enf-dru</th>\n",
+       "      <th>Enfermedades en red proyectada enf-sym</th>\n",
+       "    </tr>\n",
+       "  </thead>\n",
+       "  <tbody>\n",
+       "    <tr>\n",
+       "      <th>4</th>\n",
+       "      <td>CHEMBL548</td>\n",
+       "      <td>38</td>\n",
+       "      <td>38</td>\n",
+       "      <td>38</td>\n",
+       "      <td>30</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>2</th>\n",
+       "      <td>CHEMBL957</td>\n",
+       "      <td>30</td>\n",
+       "      <td>30</td>\n",
+       "      <td>30</td>\n",
+       "      <td>23</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>3</th>\n",
+       "      <td>CHEMBL1762</td>\n",
+       "      <td>19</td>\n",
+       "      <td>19</td>\n",
+       "      <td>19</td>\n",
+       "      <td>13</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>1</th>\n",
+       "      <td>CHEMBL334966</td>\n",
+       "      <td>7</td>\n",
+       "      <td>7</td>\n",
+       "      <td>7</td>\n",
+       "      <td>7</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>0</th>\n",
+       "      <td>CHEMBL1200810</td>\n",
+       "      <td>3</td>\n",
+       "      <td>3</td>\n",
+       "      <td>3</td>\n",
+       "      <td>3</td>\n",
+       "    </tr>\n",
+       "  </tbody>\n",
+       "</table>\n",
+       "</div>"
+      ],
+      "text/plain": [
+       "  Fármacos candidatos Epilepsia  Total enfermedades tratadas  \\\n",
+       "4                     CHEMBL548                           38   \n",
+       "2                     CHEMBL957                           30   \n",
+       "3                    CHEMBL1762                           19   \n",
+       "1                  CHEMBL334966                            7   \n",
+       "0                 CHEMBL1200810                            3   \n",
+       "\n",
+       "   Enfermedades en red proyectada enf-genes  \\\n",
+       "4                                        38   \n",
+       "2                                        30   \n",
+       "3                                        19   \n",
+       "1                                         7   \n",
+       "0                                         3   \n",
+       "\n",
+       "   Enfermedades en red proyectada enf-dru  \\\n",
+       "4                                      38   \n",
+       "2                                      30   \n",
+       "3                                      19   \n",
+       "1                                       7   \n",
+       "0                                       3   \n",
+       "\n",
+       "   Enfermedades en red proyectada enf-sym  \n",
+       "4                                      30  \n",
+       "2                                      23  \n",
+       "3                                      13  \n",
+       "1                                       7  \n",
+       "0                                       3  "
+      ]
+     },
+     "execution_count": 10,
+     "metadata": {},
+     "output_type": "execute_result"
+    }
+   ],
+   "source": [
+    "enf_candidatas_epilepsy = funciones_reposicionamiento.distribucion_enf_candidatas(spls_enfermedades_candidatas, \"Epilepsia\")\n",
+    "enf_candidatas_epilepsy.sort_values(by=\"Total enfermedades tratadas\", ascending=False).head()"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 11,
+   "id": "03517b87-5069-41b1-95a3-d71ada80ce47",
+   "metadata": {},
+   "outputs": [
+    {
+     "data": {
+      "text/html": [
+       "<div>\n",
+       "<style scoped>\n",
+       "    .dataframe tbody tr th:only-of-type {\n",
+       "        vertical-align: middle;\n",
+       "    }\n",
+       "\n",
+       "    .dataframe tbody tr th {\n",
+       "        vertical-align: top;\n",
+       "    }\n",
+       "\n",
+       "    .dataframe thead th {\n",
+       "        text-align: right;\n",
+       "    }\n",
+       "</style>\n",
+       "<table border=\"1\" class=\"dataframe\">\n",
+       "  <thead>\n",
+       "    <tr style=\"text-align: right;\">\n",
+       "      <th></th>\n",
+       "      <th>Fármacos candidatos Esquizofrenia</th>\n",
+       "      <th>Total enfermedades tratadas</th>\n",
+       "      <th>Enfermedades en red proyectada enf-genes</th>\n",
+       "      <th>Enfermedades en red proyectada enf-dru</th>\n",
+       "      <th>Enfermedades en red proyectada enf-sym</th>\n",
+       "    </tr>\n",
+       "  </thead>\n",
+       "  <tbody>\n",
+       "    <tr>\n",
+       "      <th>0</th>\n",
+       "      <td>CHEMBL1069</td>\n",
+       "      <td>65</td>\n",
+       "      <td>64</td>\n",
+       "      <td>65</td>\n",
+       "      <td>41</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>1</th>\n",
+       "      <td>CHEMBL1234886</td>\n",
+       "      <td>46</td>\n",
+       "      <td>43</td>\n",
+       "      <td>46</td>\n",
+       "      <td>34</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>2</th>\n",
+       "      <td>CHEMBL1743082</td>\n",
+       "      <td>7</td>\n",
+       "      <td>7</td>\n",
+       "      <td>7</td>\n",
+       "      <td>7</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>3</th>\n",
+       "      <td>CHEMBL861</td>\n",
+       "      <td>4</td>\n",
+       "      <td>4</td>\n",
+       "      <td>4</td>\n",
+       "      <td>4</td>\n",
+       "    </tr>\n",
+       "    <tr>\n",
+       "      <th>4</th>\n",
+       "      <td>CHEMBL1201237</td>\n",
+       "      <td>4</td>\n",
+       "      <td>4</td>\n",
+       "      <td>4</td>\n",
+       "      <td>4</td>\n",
+       "    </tr>\n",
+       "  </tbody>\n",
+       "</table>\n",
+       "</div>"
+      ],
+      "text/plain": [
+       "  Fármacos candidatos Esquizofrenia  Total enfermedades tratadas  \\\n",
+       "0                        CHEMBL1069                           65   \n",
+       "1                     CHEMBL1234886                           46   \n",
+       "2                     CHEMBL1743082                            7   \n",
+       "3                         CHEMBL861                            4   \n",
+       "4                     CHEMBL1201237                            4   \n",
+       "\n",
+       "   Enfermedades en red proyectada enf-genes  \\\n",
+       "0                                        64   \n",
+       "1                                        43   \n",
+       "2                                         7   \n",
+       "3                                         4   \n",
+       "4                                         4   \n",
+       "\n",
+       "   Enfermedades en red proyectada enf-dru  \\\n",
+       "0                                      65   \n",
+       "1                                      46   \n",
+       "2                                       7   \n",
+       "3                                       4   \n",
+       "4                                       4   \n",
+       "\n",
+       "   Enfermedades en red proyectada enf-sym  \n",
+       "0                                      41  \n",
+       "1                                      34  \n",
+       "2                                       7  \n",
+       "3                                       4  \n",
+       "4                                       4  "
+      ]
+     },
+     "execution_count": 11,
+     "metadata": {},
+     "output_type": "execute_result"
+    }
+   ],
+   "source": [
+    "enf_candidatas_schizo = funciones_reposicionamiento.distribucion_enf_candidatas(spls_enfermedades_candidatas, \"Esquizofrenia\")\n",
+    "enf_candidatas_schizo.sort_values(by=\"Total enfermedades tratadas\", ascending=False).head()"
+   ]
+  }
+ ],
+ "metadata": {
+  "kernelspec": {
+   "display_name": "Python 3 (ipykernel)",
+   "language": "python",
+   "name": "python3"
+  },
+  "language_info": {
+   "codemirror_mode": {
+    "name": "ipython",
+    "version": 3
+   },
+   "file_extension": ".py",
+   "mimetype": "text/x-python",
+   "name": "python",
+   "nbconvert_exporter": "python",
+   "pygments_lexer": "ipython3",
+   "version": "3.11.6"
+  }
+ },
+ "nbformat": 4,
+ "nbformat_minor": 5
+}