diff --git a/README.md b/README.md index 487063dd3120bac360e90ad3c81186c6050140e1..b2fa2f60f9771cb4c7a11710923d9fc8e0b06caf 100644 --- a/README.md +++ b/README.md @@ -1 +1,9 @@ -Work created by Laura Masa +This repository documents the work conducted for my master’s thesis titled "Analyzing Gene Expression Datasets for Disease Annotation Modeling." + +The principal objective of this thesis was to design and implement an automated system for the extraction, processing, and analysis of gene-disease association data. This system was developed to generate a detailed gene-disease annotation model, including gene identifiers, gene expression profiles, and comprehensive metadata. The automation of these processes was intended to provide a structured and efficient platform to support biomedical research efforts and the identification of novel therapeutic targets. + +In addition to the main objective, the thesis aimed to achieve several secondary goals: + +Differential Gene Expression Analysis: To create a Personalized Perturbation Profile (PEEP) that captures gene expression variations for individual and group-level comparisons. +Advancing Personalized Medicine: To leverage PEEP profiles for discovering tailored therapeutic interventions and exploring opportunities for drug repositioning for novel therapeutic applications. +Modeling Disease-Gene Associations: To enhance the semantic understanding and predictive accuracy of gene-disease relationships through advanced modeling techniques.