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Disnet
SEM-DISNET
Commits
383c14b3
Commit
383c14b3
authored
Jun 10, 2022
by
Andrea Alvarez Perez
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SEM-DISNET Documentation/index-en.html
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383c14b3
...
...
@@ -55,7 +55,7 @@
<div
class=
"head"
>
<div
style=
"float:right"
>
language
<a
href=
"index-en.html"
><b>
en
</b></a>
</div>
<h1><b>
SEM-DISNET
</b></h1>
<h2>
Release 2022-0
3-3
0
</h2>
<h2>
Release 2022-0
6-1
0
</h2>
<dl>
...
...
@@ -585,7 +585,7 @@ This ontology has the following classes and properties.</span>
as an attribute (
<tt>
cco:proteinSequence
</tt>
) reused from ChEMBL ontology. Each protein also belongs to a class
(
<tt>
obo:Protein class
</tt>
) and participates (
<tt>
sio:'is participant in'
</tt>
) in protein-protein interactions
(
<tt>
ncit:PPI
</tt>
). Furthermore, both Protein and Gene classes are present in Organisms (
<tt>
ncit:Organism
</tt>
),
and either Organism and Protein
are can act as a target (
<tt>
sio:'is target in'
</tt>
, being related to Target class
and either Organism and Protein
can act as a target (
<tt>
sio:'is target in'
</tt>
)
, being related to Target class
(
<tt>
cco:Target
</tt>
).
</li>
<li
type=
"circle"
><b>
Association between a Disease and a Phenotype
</b>
: this association and the related class Phenotype
(
<tt>
disnet:Phenotype
</tt>
) have been modelled
<i>
de novo
</i>
, since no existing classes were found in other
...
...
@@ -597,14 +597,13 @@ This ontology has the following classes and properties.</span>
</li></p>
<p>
The association between both central classes,
<tt>
Disease
</tt>
and
<tt>
Drug
</tt>
was reused from the CTD, the main
source from which the information stored in the DISNET database is obtained. However, this class has (
<tt>
owl:sameAs
</tt>
)
an associated class in SIO (
<tt>
sio:'chemical-disease association'
</tt>
). In addition, this association has been
modelled
<i>
de novo
</i>
with two subclasses emerging from it. Drug-disease pairs are classified into these subclasses
source from which the information stored in the DISNET database is obtained. In addition, this association has been
modelled
<i>
de novo
</i>
with three subclasses emerging from it. Drug-disease pairs are classified into these subclasses
depending on the effect the drug has on the disease. A chemical that correlates with a disease or may play a role in
the etiology of a disease, acting as a marker of those diseases (
<tt>
disnet:Drug Disease Marker
</tt>
) or it can be used
to treat the disease, having a known or potential therapeutic effect on it (
<tt>
disnet:Drug Disease Therapeutic
</tt>
).
Additionally, the association is identified
by an inferred score established by CTD-curated chemical-gene interactions
(
<tt>
sio:'has value'
</tt>
)
.
Additionally, the association is identified
as Inferred (
<tt>
disnet:Drug Disease Inferred
</tt>
)by an inferred score e
stablished by CTD-curated chemical-gene interactions when the association cannot be identified neither as Marker or Therapeutic
.
</p><p>
<li><b>
Drug class
</b>
<p>
This class (
<tt>
cco:Drug
</tt>
) was reused from ChEMBL database and represents, according to
the Chemical Entities of Biological Interest (ChEBI), any substance which when absorbed into a living organism may modify
...
...
@@ -642,7 +641,7 @@ This ontology has the following classes and properties.</span>
is specified in the boxes above the diagram, so highlighted Object Properties are subproperties of SIO and another
reused ontology.
</li>
<li
type=
"square"
><b>
Drug Drug Interaction
</b>
: is an interaction in which two drugs interact in such a way to
produce a non-additive biological response (
<tt>
sio:DDI
</tt>
). The
<m></m>
ain source (
<tt>
skos:exactMatch
</tt>
) is
produce a non-additive biological response (
<tt>
sio:DDI
</tt>
). The
m
ain source (
<tt>
skos:exactMatch
</tt>
) is
DrugBank. However, TWOSIDES provides the information about the potential adverse side effects that the DDI causes
in a phenotype, and it is related to Phenotype class by two
<i>
de novo
</i>
Object Properties (
<tt>
disnet:isSideEffect
</tt>
and
<tt>
disnet:hasSideEffect
</tt>
). Furthermore, drug participate (
<tt>
sio:'is participant in'
</tt>
) drug-drug
...
...
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