Commit 383c14b3 authored by Andrea Alvarez Perez's avatar Andrea Alvarez Perez

Update git

parent 4e2a5472
......@@ -55,7 +55,7 @@
<div class="head">
<div style="float:right">language <a href="index-en.html"><b>en</b></a> </div>
<h1><b>SEM-DISNET</b></h1>
<h2>Release 2022-03-30</h2>
<h2>Release 2022-06-10</h2>
<dl>
......@@ -585,7 +585,7 @@ This ontology has the following classes and properties.</span>
as an attribute (<tt>cco:proteinSequence</tt>) reused from ChEMBL ontology. Each protein also belongs to a class
(<tt>obo:Protein class</tt>) and participates (<tt>sio:'is participant in'</tt>) in protein-protein interactions
(<tt>ncit:PPI</tt>). Furthermore, both Protein and Gene classes are present in Organisms (<tt>ncit:Organism</tt>),
and either Organism and Protein are can act as a target (<tt>sio:'is target in'</tt>, being related to Target class
and either Organism and Protein can act as a target (<tt>sio:'is target in'</tt>), being related to Target class
(<tt>cco:Target</tt>).</li>
<li type="circle"><b>Association between a Disease and a Phenotype</b>: this association and the related class Phenotype
(<tt>disnet:Phenotype</tt>) have been modelled <i>de novo</i>, since no existing classes were found in other
......@@ -597,14 +597,13 @@ This ontology has the following classes and properties.</span>
</li></p>
<p>
The association between both central classes, <tt>Disease</tt> and <tt>Drug</tt> was reused from the CTD, the main
source from which the information stored in the DISNET database is obtained. However, this class has (<tt>owl:sameAs</tt>)
an associated class in SIO (<tt>sio:'chemical-disease association'</tt>). In addition, this association has been
modelled <i>de novo</i> with two subclasses emerging from it. Drug-disease pairs are classified into these subclasses
source from which the information stored in the DISNET database is obtained. In addition, this association has been
modelled <i>de novo</i> with three subclasses emerging from it. Drug-disease pairs are classified into these subclasses
depending on the effect the drug has on the disease. A chemical that correlates with a disease or may play a role in
the etiology of a disease, acting as a marker of those diseases (<tt>disnet:Drug Disease Marker</tt>) or it can be used
to treat the disease, having a known or potential therapeutic effect on it (<tt>disnet:Drug Disease Therapeutic</tt>).
Additionally, the association is identified by an inferred score established by CTD-curated chemical-gene interactions
(<tt>sio:'has value'</tt>).
Additionally, the association is identified as Inferred (<tt>disnet:Drug Disease Inferred</tt>)by an inferred score e
stablished by CTD-curated chemical-gene interactions when the association cannot be identified neither as Marker or Therapeutic.
</p><p>
<li><b>Drug class</b> <p>This class (<tt>cco:Drug</tt>) was reused from ChEMBL database and represents, according to
the Chemical Entities of Biological Interest (ChEBI), any substance which when absorbed into a living organism may modify
......@@ -642,7 +641,7 @@ This ontology has the following classes and properties.</span>
is specified in the boxes above the diagram, so highlighted Object Properties are subproperties of SIO and another
reused ontology.</li>
<li type="square"><b>Drug Drug Interaction</b>: is an interaction in which two drugs interact in such a way to
produce a non-additive biological response (<tt>sio:DDI</tt>). The <m></m>ain source (<tt>skos:exactMatch</tt>) is
produce a non-additive biological response (<tt>sio:DDI</tt>). The main source (<tt>skos:exactMatch</tt>) is
DrugBank. However, TWOSIDES provides the information about the potential adverse side effects that the DDI causes
in a phenotype, and it is related to Phenotype class by two <i>de novo</i> Object Properties (<tt>disnet:isSideEffect</tt>
and <tt>disnet:hasSideEffect</tt>). Furthermore, drug participate (<tt>sio:'is participant in'</tt>) drug-drug
......
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