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Disnet
SEM-DISNET
Commits
383c14b3
Commit
383c14b3
authored
Jun 10, 2022
by
Andrea Alvarez Perez
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SEM-DISNET Documentation/index-en.html
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383c14b3
...
@@ -55,7 +55,7 @@
...
@@ -55,7 +55,7 @@
<div
class=
"head"
>
<div
class=
"head"
>
<div
style=
"float:right"
>
language
<a
href=
"index-en.html"
><b>
en
</b></a>
</div>
<div
style=
"float:right"
>
language
<a
href=
"index-en.html"
><b>
en
</b></a>
</div>
<h1><b>
SEM-DISNET
</b></h1>
<h1><b>
SEM-DISNET
</b></h1>
<h2>
Release 2022-0
3-3
0
</h2>
<h2>
Release 2022-0
6-1
0
</h2>
<dl>
<dl>
...
@@ -585,7 +585,7 @@ This ontology has the following classes and properties.</span>
...
@@ -585,7 +585,7 @@ This ontology has the following classes and properties.</span>
as an attribute (
<tt>
cco:proteinSequence
</tt>
) reused from ChEMBL ontology. Each protein also belongs to a class
as an attribute (
<tt>
cco:proteinSequence
</tt>
) reused from ChEMBL ontology. Each protein also belongs to a class
(
<tt>
obo:Protein class
</tt>
) and participates (
<tt>
sio:'is participant in'
</tt>
) in protein-protein interactions
(
<tt>
obo:Protein class
</tt>
) and participates (
<tt>
sio:'is participant in'
</tt>
) in protein-protein interactions
(
<tt>
ncit:PPI
</tt>
). Furthermore, both Protein and Gene classes are present in Organisms (
<tt>
ncit:Organism
</tt>
),
(
<tt>
ncit:PPI
</tt>
). Furthermore, both Protein and Gene classes are present in Organisms (
<tt>
ncit:Organism
</tt>
),
and either Organism and Protein
are can act as a target (
<tt>
sio:'is target in'
</tt>
, being related to Target class
and either Organism and Protein
can act as a target (
<tt>
sio:'is target in'
</tt>
)
, being related to Target class
(
<tt>
cco:Target
</tt>
).
</li>
(
<tt>
cco:Target
</tt>
).
</li>
<li
type=
"circle"
><b>
Association between a Disease and a Phenotype
</b>
: this association and the related class Phenotype
<li
type=
"circle"
><b>
Association between a Disease and a Phenotype
</b>
: this association and the related class Phenotype
(
<tt>
disnet:Phenotype
</tt>
) have been modelled
<i>
de novo
</i>
, since no existing classes were found in other
(
<tt>
disnet:Phenotype
</tt>
) have been modelled
<i>
de novo
</i>
, since no existing classes were found in other
...
@@ -597,14 +597,13 @@ This ontology has the following classes and properties.</span>
...
@@ -597,14 +597,13 @@ This ontology has the following classes and properties.</span>
</li></p>
</li></p>
<p>
<p>
The association between both central classes,
<tt>
Disease
</tt>
and
<tt>
Drug
</tt>
was reused from the CTD, the main
The association between both central classes,
<tt>
Disease
</tt>
and
<tt>
Drug
</tt>
was reused from the CTD, the main
source from which the information stored in the DISNET database is obtained. However, this class has (
<tt>
owl:sameAs
</tt>
)
source from which the information stored in the DISNET database is obtained. In addition, this association has been
an associated class in SIO (
<tt>
sio:'chemical-disease association'
</tt>
). In addition, this association has been
modelled
<i>
de novo
</i>
with three subclasses emerging from it. Drug-disease pairs are classified into these subclasses
modelled
<i>
de novo
</i>
with two subclasses emerging from it. Drug-disease pairs are classified into these subclasses
depending on the effect the drug has on the disease. A chemical that correlates with a disease or may play a role in
depending on the effect the drug has on the disease. A chemical that correlates with a disease or may play a role in
the etiology of a disease, acting as a marker of those diseases (
<tt>
disnet:Drug Disease Marker
</tt>
) or it can be used
the etiology of a disease, acting as a marker of those diseases (
<tt>
disnet:Drug Disease Marker
</tt>
) or it can be used
to treat the disease, having a known or potential therapeutic effect on it (
<tt>
disnet:Drug Disease Therapeutic
</tt>
).
to treat the disease, having a known or potential therapeutic effect on it (
<tt>
disnet:Drug Disease Therapeutic
</tt>
).
Additionally, the association is identified
by an inferred score established by CTD-curated chemical-gene interactions
Additionally, the association is identified
as Inferred (
<tt>
disnet:Drug Disease Inferred
</tt>
)by an inferred score e
(
<tt>
sio:'has value'
</tt>
)
.
stablished by CTD-curated chemical-gene interactions when the association cannot be identified neither as Marker or Therapeutic
.
</p><p>
</p><p>
<li><b>
Drug class
</b>
<p>
This class (
<tt>
cco:Drug
</tt>
) was reused from ChEMBL database and represents, according to
<li><b>
Drug class
</b>
<p>
This class (
<tt>
cco:Drug
</tt>
) was reused from ChEMBL database and represents, according to
the Chemical Entities of Biological Interest (ChEBI), any substance which when absorbed into a living organism may modify
the Chemical Entities of Biological Interest (ChEBI), any substance which when absorbed into a living organism may modify
...
@@ -642,7 +641,7 @@ This ontology has the following classes and properties.</span>
...
@@ -642,7 +641,7 @@ This ontology has the following classes and properties.</span>
is specified in the boxes above the diagram, so highlighted Object Properties are subproperties of SIO and another
is specified in the boxes above the diagram, so highlighted Object Properties are subproperties of SIO and another
reused ontology.
</li>
reused ontology.
</li>
<li
type=
"square"
><b>
Drug Drug Interaction
</b>
: is an interaction in which two drugs interact in such a way to
<li
type=
"square"
><b>
Drug Drug Interaction
</b>
: is an interaction in which two drugs interact in such a way to
produce a non-additive biological response (
<tt>
sio:DDI
</tt>
). The
<m></m>
ain source (
<tt>
skos:exactMatch
</tt>
) is
produce a non-additive biological response (
<tt>
sio:DDI
</tt>
). The
m
ain source (
<tt>
skos:exactMatch
</tt>
) is
DrugBank. However, TWOSIDES provides the information about the potential adverse side effects that the DDI causes
DrugBank. However, TWOSIDES provides the information about the potential adverse side effects that the DDI causes
in a phenotype, and it is related to Phenotype class by two
<i>
de novo
</i>
Object Properties (
<tt>
disnet:isSideEffect
</tt>
in a phenotype, and it is related to Phenotype class by two
<i>
de novo
</i>
Object Properties (
<tt>
disnet:isSideEffect
</tt>
and
<tt>
disnet:hasSideEffect
</tt>
). Furthermore, drug participate (
<tt>
sio:'is participant in'
</tt>
) drug-drug
and
<tt>
disnet:hasSideEffect
</tt>
). Furthermore, drug participate (
<tt>
sio:'is participant in'
</tt>
) drug-drug
...
...
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